A5014398160- European and International Contract Law
- Conflict of Laws and Jurisdiction
- Legal principles and applications
- Law, logistics, and international trade
- Medical and Health Sciences Research
- Cardiac, Anesthesia and Surgical Outcomes
- Diverse Legal and Medical Studies
- Criminal Law and Policy
- Law and Political Science
- European and International Law Studies
- Neurogenesis and neuroplasticity mechanisms
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Law, Economics, and Judicial Systems
- Spinal Cord Injury Research
- Corporate Governance and Law
- Acute Ischemic Stroke Management
- Medical Practices and Rehabilitation
- Nerve injury and regeneration
- Hemodynamic Monitoring and Therapy
- Axon Guidance and Neuronal Signaling
- Hip and Femur Fractures
- Taxation and Legal Issues
- Adipose Tissue and Metabolism
- HIV, Drug Use, Sexual Risk
Roche (Switzerland)
2013-2025
Guy's and St Thomas' NHS Foundation Trust
2024
University of Freiburg
2016-2022
Luzerner Kantonsspital
2022
Max Planck Institute for Comparative and International Private Law
1998-2020
St Thomas' Hospital
2020
Max Planck Society
1998-2020
ETH Zurich
2015-2019
The University of Queensland
2019
Technical University of Munich
2018
Abstract Small molecule splicing modifiers have been previously described that target the general machinery and thus low specificity for individual genes. Several potent molecules correcting deficit of SMN2 (survival motor neuron 2) gene identified these are moving towards a potential therapy spinal muscular atrophy (SMA). Here by using combination RNA splicing, transcription, protein chemistry techniques, we show directly bind to two distinct sites pre-mRNA, thereby stabilizing yet...
Abstract Objective To prospectively assess the construct and criterion validity of ClassIntra version 1.0, a newly developed classification for assessing intraoperative adverse events. Design International, multicentre cohort study. Setting 18 secondary tertiary centres from 12 countries in Europe, Oceania, North America. Participants The study included representative sample 2520 patients hospital having any type surgery, followed up until discharge. A follow-up to mortality at 30 days was...
Abstract Although chromosome partitioning during mitosis is well studied, the molecular mechanisms that allow proper segregation of cytoplasmic organelles in human cells are poorly understood. Here we show mitochondria interact with growing microtubule tips and transported towards daughter cell periphery at end mitosis. This phenomenon promoted by direct cycle-dependent interaction mitochondrial protein Miro cytoskeletal-associated Cenp-F. Cenp-F recruited to time cytokinesis associates...
Traumatic spinal cord injury (TSCI) has a high personal and socio-economic impact. Effective public health prevention policies that aim to reduce this burden are reliant on contemporary information of the risk underlying causes TSCI. This study contextualizes Swiss annual incidence rates within European context, provides detailed estimates by age, gender etiology towards informing targeted intervention strategies.TSCI cases occurred in years 2005 2012 were identified as part Spinal Cord...
Angelman syndrome (AS) is a neurodevelopmental disorder caused by the loss of maternal UBE3A, ubiquitin protein ligase E3A. Here, we study neurons derived from patients with AS and neurotypical individuals, reciprocally modulate UBE3A using antisense oligonucleotides. Unbiased proteomics reveal proteins that are regulated in disease-specific manner, including PEG10, retrotransposon-derived GAG protein. PEG10 increase, but not RNA, dependent on proteasome function. binds to both RNA...
The authors undertook a prospective study of frameless, magnetic resonance (MR)-guided stereotactic brain biopsy procedures performed with the aid an open MR system. Morbidity and mortality rates, frequency postoperative hemorrhage, histological yield were evaluated, as well size location lesions under investigation.During period 51 months (July 1996-November 2000), 114 consecutive frameless intraoperative system to investigate supratentorial in 113 patients. median volume was 33.5 cm3,...
Chin lift and jaw thrust are two common maneuvers used to improve the patency of upper airway during general anesthesia. We investigated effect these combined with continuous positive pressure (CPAP) on size glottic opening stridor score. Forty children, aged 2--9 yr, premedicated midazolam spontaneously breathing end-tidal 1% halothane equal parts nitrous oxide oxygen, were studied. A flexible fiberoptic bronchoscope was placed via mask one nostril level junction soft palate oropharynx....
Abstract Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A. Restoring UBE3A levels potential disease-modifying therapy for AS and has recently entered clinical trials. There paucity data regarding molecular changes downstream hampering elucidation disease therapeutics biomarkers. Notably, plays an important role in nucleus but its targets have yet to be elucidated. Using proteomics, we assessed during postnatal cortical development...
Here, we developed a CRISPR-Cas9 arrayed screen to investigate lipid handling pathways in human induced pluripotent stem cell (iPSC)-derived microglia. We established robust method for the nucleofection of ribonucleoprotein complexes into iPSC-derived myeloid cells, enabling genetic perturbations. Using this approach, performed targeted identify key regulators droplet formation dependent on Apolipoprotein E (APOE). Mammalian Target Rapamycin Complex 1 (mTORC1) signaling pathway as critical...
During development, the p75 neurotrophin receptor (p75NTR) is widely expressed in nervous system where it regulates neuronal differentiation, migration and axonal outgrowth. p75NTR also mediates survival death of newly born neurons, with functional outcomes being dependent on both timing cellular context. Here we show that knockout from embryonic day 10 (E10) neural progenitors using a conditional Nestin-Cre; floxed mouse causes increased apoptosis progenitor cells. By E14.5, number...
Abstract A multitude of various materials are available for the visualization cadaveric vessels, ranging from natural like gelatin and latex to synthetic silicone rubber or acrylates. To achieve a detailed overview vascular architecture in microvascular studies experimental flap surgery, injected material should have low viscosity assure perfusion even smallest vessels. In addition, ideally either no only minimal shrinkage, harden within reasonable time, but retain sufficient elasticity...
According to the English law of restitution, a payment under mistake fact can usually be recovered from recipient, at least if is liability or “fundamental”. In three-party situations situation therefore seems straight-forward: independently relationship each three parties other, plaintiff payer and defendant recipient. However, closer look into case literature reveals that there are problems.
Socio-behavioural factors may contribute to the wide variance in HIV prevalence between and within sub-Saharan African (SSA) countries. We studied associations socio-behavioural variables potentially related risk of acquiring HIV.We used Bayesian network models study that be HIV. A consists nodes representing variables, edges conditional dependencies variables. analysed data from Demographic Health Surveys conducted 29 SSA countries 2010 2016. predefined dichotomized 12 including age,...
The association of blood pressure (BP) and hypertension with the presence different types brain lesions in patients atrial fibrillation is unclear. BP values were obtained a multicenter cohort fibrillation. Systolic diastolic was categorized predefined groups. All underwent magnetic resonance imaging neurocognitive testing. Brain classified as large noncortical or cortical infarcts, small microbleeds, white matter lesions. White graded according to Fazekas scale. Overall, 1738 enrolled this...