A5001591487- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Eosinophilic Esophagitis
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Animal Behavior and Reproduction
- Cardiac Imaging and Diagnostics
- Pneumonia and Respiratory Infections
- Surgical site infection prevention
- Avian ecology and behavior
- ECG Monitoring and Analysis
- Venous Thromboembolism Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- Eosinophilic Disorders and Syndromes
- Frailty in Older Adults
- Heart Failure Treatment and Management
- Respiratory viral infections research
University Hospital of Basel
2015-2024
University of Basel
2008-2024
University of Bern
2008-2021
Primary HealthCare
2021
Primary Health Care
2021
University Hospital of Zurich
2021
Population Health Research Institute
2021
McMaster University
2021
Ospedale San Giovanni Bellinzona
2021
Ospedale regionale di Lugano
2021
1. Predation risk is known to influence behaviour and development, especially in breeding animals. Mothers may be selected transfer information about the intensity of such their offspring through maternal effects thus development. 2. Here, we test for this effect via manipulation perceived predation by exposing great tit females before during ovulation stuffed models sounds either a predator bird (sparrowhawk –Accipiter nisus) or non-predatory control (song thrush –Turdus philomelos)...
Abstract Aims We aimed to investigate the association of clinically overt and silent brain lesions with cognitive function in atrial fibrillation (AF) patients. Methods results enrolled 1227 AF patients a prospective, multicentre cohort study (Swiss-AF). Patients underwent standardized magnetic resonance imaging (MRI) at baseline after 2 years. quantified new small non-cortical infarcts (SNCIs) large or cortical (LNCCIs), white matter (WML), microbleeds (Mb). Clinically, were defined as...
Background: Patients at high-bleeding risk (HBR) undergoing percutaneous coronary intervention represent a challenging patient population. The use of drug-coated balloon (DCB) allows shorter duration dual antiplatelet therapy compared with drug-eluting stents (DES) and reduces thrombotic due to the absence permanent implant. present analysis aimed investigate if effect DCB versus DES differed between patients without HBR treated in small arteries. Methods: This prespecified subgroup...
Background Knowledge about determinants of quality life (QoL) in eosinophilic oesophagitis (EoO) patients helps to identify at risk experiencing poor QoL and tailor therapeutic interventions accordingly. Aim To evaluate the impact symptom severity, endoscopic histological activity on EoE-specific adult EoE patients. Methods Ninety-eight were prospectively included (64% male, median age 39 years). Patients completed two validated instruments assess (EoO-QoL-A) severity (adult index...
Serum neurofilament light chain (sNfL) is increasingly used as a neuroaxonal injury biomarker in the elderly. Besides age, little known about how other physiological factors like renal function and body mass index (BMI) alter its levels. Here, we investigated association of estimated glomerular filtration rate (eGFR) BMI with sNfL large sample elderly patients atrial fibrillation (AF).This cross-sectional analysis from Swiss-AF Cohort (NCT02105844). We measured using an ultrasensitive...
Objective Trimethylamine-N-oxide (TMAO) is a metabolite derived from the microbial processing of dietary phosphatidylcholine and carnitine subsequent hepatic oxidation. Due to its prothrombotic inflammatory mechanisms, we aimed assess role in prediction adverse events susceptible population, namely patients with atrial fibrillation. Methods Baseline TMAO plasma levels were measured by liquid chromatography-tandem mass spectrometry 2379 subjects ongoing Swiss Atrial Fibrillation cohort. 1722...
Background Patients with atrial fibrillation (AF) face an increased risk of death and major adverse cardiovascular events (MACE). We aimed to assess the predictive value novel atrial-specific biomarker BMP10 (bone morphogenetic protein 10) for MACE in patients AF comparison NT-proBNP (N-terminal prohormone B-type natriuretic peptide). Methods Results were measured enrolled Swiss-AF (Swiss Atrial Fibrillation Study), a prospective multicenter cohort study. A total 2219 included (median...
Diarrhea is frequent in patients intensive care units (ICU) and associated with discomfort complications may increase the length of stay nursing workload. This was a prospective, double-blind, randomized, controlled single-center pilot study to assess incidence frequency diarrhea respective effects modified enteral diet (intervention: Peptamen® AF, rich proteins, medium chain triglycerides fish oil) compared standard (control: Isosource® Energy) 90 randomized adult (intervention, n = 46;...
Summary Background Omalizumab has been shown to be effective in treating chronic spontaneous urticaria ( CSU ). The reduction Fcε RI receptor density on the surface of basophils and mast cells is thought play a major role its effectiveness. We conducted double‐blind, randomized, placebo‐controlled trial investigate mode action omalizumab patients with antihistamine‐resistant . Methods Thirty were randomized 2:1 ratio receive either 300 mg or placebo. Four monthly applications...
Abstract Comparative clinical studies of children and adults with immune thrombocytopenia (ITP) are poorly covered in the literature. However, accepted classification ITP—childhood ITP adult ITP—results considerable differences treatment protocols practice guidelines. The analysis Pediatric Adult Registry on Chronic (PARC‐ITP) patients at first presentation demonstrated fewer laboratory findings initial diagnosis between than expected. present report 2‐year follow‐up data supports hypothesis...
Abstract Aims Atrial fibrillation (AF) and frailty are common, the prevalence is expected to rise further. We aimed investigate of ability a index (FI) predict unplanned hospitalizations, stroke, bleeding, death in patients with AF. Methods results Patients known AF were enrolled prospective cohort study Switzerland. Information on medical history, lifestyle factors, clinical measurements obtained. The primary outcome was hospitalization; secondary outcomes all-cause mortality, stroke. FI...
Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed patients atrial fibrillation (AF). We hypothesized that parameters of may be predictive cardiovascular death AF. Methods and Results From the multicenter prospective Swiss‐AF (Swiss Atrial Fibrillation) Cohort Study, we enrolled 1922 who were rhythm or Resting ECG recordings 5‐minute duration obtained at baseline. Standard (HRV triangular...
There is no "gold standard" for assessing disease activity in patients with eosinophilic esophagitis (EoE). We aimed to compare physicians' judgment of EoE patients' symptom severity. also examine the relative contribution symptoms as well endoscopic and histologic findings shaping activity.Six gastroenterologists (all experts) assessed EoE-associated adult patients. Patients completed a instrument provided global assessment severity (PatGA) (Likert scale: 0 (inactive) 10 (most active))....
Anaemia and thyroid dysfunction are common often co-occur. Current guidelines recommend the assessment of function in work-up anaemia, although evidence on this association is scarce.In 'European Prospective Investigation Cancer' (EPIC)-Norfolk population-based cohort, we aimed to examine prevalence type anaemia (defined as haemoglobin <13 g/dl for men <12 women) according different groups.The mean age 8791 participants was 59·4 (SD 9·1) years 55·2% were women. Thyroid present 437 (5·0%) 517...
Atrial remodelling, defined as a change in atrial structure, promotes fibrillation (AF). Bone morphogenetic protein 10 (BMP10) is an atrial-specific biomarker released to blood during development and structural changes. We aimed validate whether BMP10 associated with AF recurrence after catheter ablation (CA) large cohort of patients.We measured baseline plasma concentrations patients who underwent first elective CA the prospective Swiss-AF-PVI study. The primary outcome was lasting longer...
Rapid assessment and intervention is important for the prognosis of acutely ill patients admitted to emergency department (ED). The aim this study was prospectively develop validate a model predicting risk in-hospital death based on all available information at time ED admission compare its discriminative performance with non-systematic estimate by triaging first health-care provider. Prospective cohort analysis multivariable logistic regression probability death. A total 8,607 consecutive...