A5041523915- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Central Venous Catheters and Hemodialysis
- Sexual Differentiation and Disorders
- Acute Ischemic Stroke Management
- Chronic Disease Management Strategies
- Testicular diseases and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Obesity, Physical Activity, Diet
- Pharmaceutical Practices and Patient Outcomes
- Sepsis Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Acute Myocardial Infarction Research
- Urticaria and Related Conditions
- Reproductive Biology and Fertility
- Healthcare cost, quality, practices
- Smoking Behavior and Cessation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ovarian function and disorders
- Complement system in diseases
- Medication Adherence and Compliance
- Otitis Media and Relapsing Polychondritis
University of Bern
2017-2025
Takeda (United States)
2023
University Hospital of Bern
2021
Institute of Social and Preventive Medicine
2017-2020
To study the effects of a primary care medication review intervention centred around an electronic clinical decision support system (eCDSS) on appropriateness and number prescribing omissions in older adults with multimorbidity polypharmacy compared discussion about line usual care.Cluster randomised trial.Swiss care, between December 2018 February 2021.Eligible patients were ≥65 years age three or more chronic conditions five long term medications.The to optimise pharmacotherapy eCDSS was...
Summary Background Omalizumab has been shown to be effective in treating chronic spontaneous urticaria ( CSU ). The reduction Fcε RI receptor density on the surface of basophils and mast cells is thought play a major role its effectiveness. We conducted double‐blind, randomized, placebo‐controlled trial investigate mode action omalizumab patients with antihistamine‐resistant . Methods Thirty were randomized 2:1 ratio receive either 300 mg or placebo. Four monthly applications...
The tumour markers alpha-fetoprotein (AFP), beta human chorionic gonadotropin (βHCG), and lactate dehydrogenase (LDH) have established roles in the management follow-up of testicular cancer. While a marker rise can serve as an indicator relapse, frequency false-positive events has not been studied systematically larger cohorts. We assessed validity serum for detection relapse Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS). This registry was set up to answer questions on...
Systemic sclerosis (SSc) is a heterogeneous disease with frequently associated interstitial lung (SSc-ILD). We aimed to determine the prognostic potential of phenotyping patients SSc and SSc-ILD by inflammation describe trajectories stratified immunosuppressive treatment.
Background Studies found an association between anemia and overall mortality major bleeding (MB) in patients with acute venous thromboembolism (VTE), but whether is causally related to death, bleeding, or recurrent VTE uncertain. Objectives To explore the at baseline short-/long-term clinical outcomes a prospective cohort of 928 VTE. Methods We defined as hemoglobin <13 g/dL for men/< 12 women. The primary outcome was mortality, secondary were MB 3 months (short term) over entire...
Older patients with venous thromboembolism (VTE) are underrepresented in clinical anticoagulation trials. We examined to which extent elderly VTE would be excluded from such trials and compared the bleeding risk between hypothetically enrolled patients. studied 991 aged ≥65 years acute a prospective multicenter cohort. identified 12 landmark oral eighth updated ninth American College of Chest Physician Guidelines. For each trial, we abstracted exclusion criteria calculated proportion our...
Abstract Objectives Giant cell arteritis (GCA) may lead to vision loss. To what extent tocilizumab (TCZ) is able prevent loss unknown. The aim was analyze the occurrence of in a large GCA cohort treated with TCZ. Methods In this observational monocentric study, patients TCZ between years 2010 and 2018 were studied. Demographic, clinical, laboratory data analyzed. Results A total 186 included (62% female); 109 (59%) fulfilled American College Rheumatology (ACR) criteria, 123 (66%) patients,...
Timing of ovulation triggering is essential in infertility treatments including based on natural menstrual cycles. However, data follicle size and oestradiol (E2) concentration are limited. Therefore, the model cycle IVF (NC-IVF) was applied to provide more detailed information these parameters better schedule optimal time for ovulation.A retrospective cross-sectional analysis 606 monofollicular NC-IVF cycles performed at a university-based centre from 2016 2019. Follicle E2 LH serum...
BACKGROUND Physician well-being has an impact on productivity and quality of care. Residency training is a particularly stressful period. OBJECTIVE To assess the general internal medicine (GIM) residents its association with personal work-related factors. METHODS We conducted anonymous electronic survey among GIM from 13 Swiss teaching hospitals. explored between reduced (≥5 points based Well-Being Index [PWBI]) factors using multivariable mixed-effects logistic regression. RESULTS The...
Abstract Background In elderly patients with venous thromboembolism (VTE), the decision to extend anticoagulation beyond 3 months must be weighed against bleeding risk. We compared predictive performance of 10 clinical scores (VTE-BLEED, Seiler, Kuijer, Kearon, RIETE, ACCP, OBRI, HEMORR2HAGES, HAS-BLED, ATRIA) in receiving extended for VTE. Methods a multicenter Swiss cohort study, we analyzed 743 aged ≥65 years who received treatment vitamin K antagonists after The outcomes were time first...
Older patients anticoagulated for venous thromboembolism (VTE) have an increased risk of bleeding compared with younger patients. Little is known about the clinical impact anticoagulation-related in this growing patient group. To prospectively assess incidence, impact, and predictors older VTE, we analyzed 981 aged ≥65 years acute VTE a prospective multicenter cohort. Eight-eight percent were vitamin K antagonists. Outcomes occurrence major (MB) or clinically relevant nonmajor (CRNMB) event...
Echocardiographic parameters of diastolic function depend on cardiac loading conditions, which are altered by positive pressure ventilation. The direct effects end-expiratory (PEEP) unknown.Twenty-five patients without apparent dysfunction undergoing coronary angiography were ventilated noninvasively at PEEPs 0, 5, and 10 cmH2O (in randomized order). assessment pressure-volume-loop analysis from conductance catheters compared. time constant for decay (τ) was modeled with exponential decay....
Pharmacological thromboprophylaxis slightly increases bleeding risk. The only risk assessment model to predict in medical inpatients, the IMPROVE score, has never been validated using prospectively collected outcome data.
Long-term cardiovascular health effects of marijuana are understudied. Future disease is often indicated by subclinical atherosclerosis for which carotid intima-media thickness an established parameter.Using the data from Coronary Artery Risk Development in Young Adults (CARDIA) study, a cohort 5115 Black and white women men at Year 20 visit, we studied association between midlife lifetime exposure to (1 year = 365 days use) tobacco smoking pack-year cigarettes/day days). We measured...