A5091172284- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Child Nutrition and Feeding Issues
- Helicobacter pylori-related gastroenterology studies
- Asthma and respiratory diseases
- Delphi Technique in Research
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Urological Disorders and Treatments
- Diabetes Management and Research
- Advances in Oncology and Radiotherapy
- Cytokine Signaling Pathways and Interactions
- Foreign Body Medical Cases
- Vascular anomalies and interventions
- Dysphagia Assessment and Management
- Consumer Attitudes and Food Labeling
- Occupational and environmental lung diseases
- Pharmacy and Medical Practices
- Health Systems, Economic Evaluations, Quality of Life
- Microscopic Colitis
- Global Health Care Issues
Northwestern University
2016-2025
Northwestern Medicine
2021-2024
Northwestern University
2020
RELX Group (Netherlands)
2020
Research Network (United States)
2015
Health First
2013
University Gastroenterology
2007-2011
Northwestern Memorial Hospital
2009
Foundation for Human Potential
2008
Barro Colorado Island
2008
Esophageal eosinophilia and eosinophilic esophagitis (EoE) are increasingly recognized prevalent conditions, which now represent common clinical problems encountered by gastroenterologists, pathologists, allergists. The study of EoE has become a dynamic field with an evolving understanding the pathogenesis, diagnosis, treatment. Although there limited data supporting management decisions, parameters needed to guide care patients eosinophilic-esophageal disorders. In this evidence-based...
<h3>Abstract</h3> Brain-machine interfaces (BMIs) hold promise for the restoration of sensory and motor function treatment neurological disorders, but clinical BMIs have not yet been widely adopted, in part because modest channel counts limited their potential. In this white paper, we describe Neuralink's first steps toward a scalable high-bandwidth BMI system. We built arrays small flexible electrode "threads", with as many 3,072 electrodes per array distributed across 96 threads. also...
Esophageal dilation often leads to long-lasting relief of dysphagia in eosinophilic esophagitis (EoE). The aim this study was define the effectiveness, safety, and patient acceptance esophageal EoE. In addition, we examined influence on underlying inflammation.Two databases including 681 EoE patients were reviewed. Cohort 1 consisted treated with alone, whereas cohort 2 included a combination antieosinophilic medication. Patients from underwent prospective histological reexamination an...
Esophagogastric junction (EGJ) distensibility and distension-mediated peristalsis can be assessed with the functional lumen imaging probe (FLIP) during a sedated upper endoscopy. We aimed to describe esophageal motility assessment using FLIP topography in patients presenting dysphagia.In all, 145 (aged 18-85 years, 54% female) dysphagia that completed endoscopy 16-cm assembly high-resolution manometry (HRM) were included. HRM was analyzed according Chicago Classification of disorders; major...
Eosinophilic gastritis and duodenitis are characterized by gastrointestinal mucosal eosinophilia, chronic symptoms, impaired quality of life, a lack adequate treatments. Mast-cell activity may contribute to the pathogenesis conditions. AK002 (lirentelimab) is an anti-Siglec-8 antibody that depletes eosinophils inhibits mast cells has shown potential in animal models as treatment for eosinophilic duodenitis.In this phase 2 trial, we randomly assigned adults who had symptomatic gastritis,...
Introduction Eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis ( non‐EoE EGIDs ) are rare chronic inflammatory of the (GI) tract. Diagnosis is based on clinical symptoms and histologic findings inflammation after exclusion a secondary cause or systemic disease. Currently, no guidelines exist for evaluation . Therefore, European Society Paediatric Gastroenterology, Hepatology Nutrition (ESPGHAN) North American Pediatric (NASPGHAN) formed task force group to provide...
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus. It diagnosed in setting symptoms esophageal dysfunction and an eosinophilic predominant infiltrate The condition rapidly increasing incidence prevalence commonly encountered gastroenterology allergy practices, emergency departments, primary care settings. Over past decade, there have been paradigm shifts diagnosis management, increases knowledge about EoE risk factors, natural history, pathogenesis,...
The diagnosis of eosinophilic esophagitis (EoE) is based on histologic findings eosinophilia in the esophageal squamous epithelium patients presenting with symptoms. Variability degree epithelial eosinophil infiltration presents a challenge to diagnostic accuracy. We examined histopathologic features well-defined cohort children EoE derive an optimal number biopsies needed for diagnosis.A total 30 diagnosed on>15 eosinophils per high-power field (eos/HPF) were evaluated. was persistent...
Objective The microbiome has been implicated in the pathogenesis of a number allergic and inflammatory diseases. mucosa affected by eosinophilic esophagitis (EoE) is composed stratified squamous epithelia contains intraepithelial eosinophils. To date, no studies have identified esophageal patients with EoE or impact treatment on these organisms. aim this study was to identify determine whether treatments change profile. We hypothesized that clinically relevant alterations bacterial...
Background Although most of the patients with eosinophilic esophagitis (EoE) have mucosal and structural changes that could potentially explain their symptoms, it is unclear whether EoE associated abnormal esophageal motor function. The aims this study were to evaluate pressure topography (EPT) findings in compare them controls gastro-esophageal disease (GERD). Methods Esophageal studies 48 patients, GERD 50 compared. contractile pattern was described for ten 5-mL swallows each subject...
Aliment Pharmacol Ther 2011; 34: 790–798 Summary Background Eosinophilic oesophagitis (EoO) is a chronic disease characterised by significant symptoms and challenging treatment regimens. Health-related quality of life (HRQOL) useful way to direct patient care. EoO may impact HRQOL. Currently, there no reliable valid measure adult Aim To validate the Adult Oesophagitis Quality Life (EoO-QOL-A) questionnaire as HRQOL in this population. Methods The patients aged 18–70 recruited via an...