A5069685950- Potassium and Related Disorders
- Eosinophilic Esophagitis
- Magnesium in Health and Disease
- Membrane-based Ion Separation Techniques
- Cardiac electrophysiology and arrhythmias
- Eosinophilic Disorders and Syndromes
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Anesthesia and Pain Management
- Peripheral Artery Disease Management
- Mast cells and histamine
- Gastrointestinal disorders and treatments
- Urticaria and Related Conditions
- Pneumocystis jirovecii pneumonia detection and treatment
- Clinical Nutrition and Gastroenterology
- Bipolar Disorder and Treatment
- Chemical Synthesis and Characterization
- IL-33, ST2, and ILC Pathways
- Cardiac Arrhythmias and Treatments
- Geological and Geochemical Analysis
- Pain Management and Opioid Use
- CAR-T cell therapy research
- Digestive system and related health
Allakos (United States)
2018-2023
University of Oslo
2023
Oslo University Hospital
2023
Energy Norway
2021
UiT The Arctic University of Norway
2018
ZSX Medical (United States)
2014-2016
Aarhus University
1989-2015
Academic Medical Research Institute
2015
Wayne State University
2015
The University of Texas Health Science Center at San Antonio
2015
Background— “Therapeutic angiogenesis” seeks to improve perfusion by the growth of new blood vessels. The Regional Angiogenesis with Vascular Endothelial factor (RAVE) trial is first major randomized study adenoviral vascular endothelial (VEGF) gene transfer for treatment peripheral artery disease (PAD). Methods and Results— This phase 2, double-blind, placebo-controlled was designed test efficacy safety intramuscular delivery AdVEGF121, a replication-deficient adenovirus encoding...
Hyperkalemia (serum potassium level, >5.0 mmol per liter) is associated with increased mortality among patients heart failure, chronic kidney disease, or diabetes. We investigated whether sodium zirconium cyclosilicate (ZS-9), a novel selective cation exchanger, could lower serum levels in hyperkalemia.
<h3>Importance</h3> Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of lack effective therapies. Sodium zirconium cyclosilicate nonabsorbed cation exchanger selectively binds potassium in the intestine. <h3>Objective</h3> To evaluate efficacy and safety for 28 days patients with hyperkalemia. <h3>Design, Setting, Participants</h3> HARMONIZE was phase 3, multicenter, randomized, double-blind, placebo-controlled trial evaluating outpatients hyperkalemia...
Eosinophilic gastritis and duodenitis are characterized by gastrointestinal mucosal eosinophilia, chronic symptoms, impaired quality of life, a lack adequate treatments. Mast-cell activity may contribute to the pathogenesis conditions. AK002 (lirentelimab) is an anti-Siglec-8 antibody that depletes eosinophils inhibits mast cells has shown potential in animal models as treatment for eosinophilic duodenitis.In this phase 2 trial, we randomly assigned adults who had symptomatic gastritis,...
TNFerade is a replication deficient adenovector that expresses human tumor necrosis factor alpha under control of the radiation-inducible Egr-1 promoter. The goals this study were to determine safety and toxicity in combination with radiation therapy.TNFerade was administered by intratumoral administration, weekly for 6 weeks concomitant (30 70 Gy). Seven dose levels studied (4 x 10(7) particle units [pu] 4 10(11) pu) patients solid tumors being treated radiation.Thirty-six assessable 30...
Hyperkalemia, a condition in which serum potassium ions (K+) exceed 5.0 mmol/L, is common electrolyte disorder associated with substantial morbidity. Current methods of managing hyperkalemia, including organic polymer resins such as sodium polystyrene sulfonate (SPS), are poorly tolerated and/or not effective. Sodium zirconium cyclosilicate (ZS-9) under clinical development an orally administered, non-absorbed, novel, inorganic microporous silicate compound that selectively removes excess K+...
Hyperkalemia contributes to significant mortality and limits the use of cardioprotective renoprotective renin-angiotensin-aldosterone blockers. Current therapies are poorly tolerated not always effective. Here we conducted a phase 2 randomized, double-blind, placebo-controlled dose-escalation study assess safety efficacy ZS-9. This oral selective cation exchanger that preferentially entraps potassium in gastrointestinal tract was given patients with stable Stage 3 chronic kidney disease...
Aberrant accumulation and activation of eosinophils potentially mast cells (MCs) contribute to the pathogenesis eosinophilic gastrointestinal diseases (EGIDs), including esophagitis (EoE), gastritis (EG), gastroenteritis (EGE). Current treatment options, such as diet restriction corticosteroids, have limited efficacy are often inappropriate for chronic use. One promising new approach is deplete inhibit MCs with a monoclonal antibody (mAb) against sialic acid-binding immunoglobulin-like...
BackgroundChronic urticaria (CU) is a debilitating mast cell–driven disease, often refractory to standard therapy (ie, antihistamines). Lirentelimab, an anti–sialic acid–binding immunoglobulin-like lectin 8 mAb, selectively inhibits cells and depletes eosinophils.ObjectiveWe sought determine safety efficacy of lirentelimab in patients with CU.MethodsThis phase 2a study enrolled CU up 4-fold H1-antihistamine doses. Patients received 6 monthly intravenous doses (0.3, 1, 3 mg/kg). Primary end...
This paper describes the setting, structure, and textural relations of Platinova reefs in Skaergaard intrusion. The comprise a strata-bound occurrence Au + PGE estimated at 91 million tons rock with 1.8 ppm similar amounts Pd. precious metals occur two major zones, lower Pd reef which is concordant modal layering followed by least ten minor (also concordant), an concentration fringes outward upward through Triple Group units. are separated systematic way across Near center intrusion, occurs...
Rasmussen HS, Holtug K, Mortensen PB. Degradation of amino acids to short-chain fatty in humans. An vitro study. Scand J Gastroenterol 1988, 23, 178–182Short-chain (SCFA) originate mainly the colon through bacterial fermentation polysaccharides. To test hypothesis that SCFA may from polypeptides as well, production these albumin and specific was examined a faecal incubation system. Albumin converted all CZCS-fatty acids, whereas generally were SCFA, most often combination deamination...
To help define the safety profile of use adenovirus (Ad) gene transfer vectors in humans, this report summarizes our experience since April 1993 local administration E1(-)/E3(-) Ad to humans using low (<10(9) particle units) or intermediate (10(9)-10(11) doses. Included study are 90 individuals and 12 controls, with diverse comorbid conditions, including cystic fibrosis, colon cancer metastatic liver, severe coronary artery disease, peripheral vascular as well normals. These received 140...
• In a double-blind, placebo-controlled study, 47 patients with ischemic heart disease and acute myocardial infarction were allocated to 3 months' treatment peroral magnesium (15 mmol/d) or placebo. Before, during, after treatment, blood samples taken determine serum concentrations of cholesterol; triglyceride; high-density, low-density, very-low-density lipoprotein; apolipoprotein A1 B; magnesium. We found 13% increase in molar ratio A1:apolipoprotein B as compared 2% the placebo group (for...
Background: Ultrasound (US)‐guided supraclavicular or infraclavicular blocks are commonly used for upper extremity surgery. The aims of this randomized study were to compare the block performance and onset times, effectiveness, incidence adverse events patient's acceptance US‐guided blocks. We hypothesized that approach, being more superficial easier visualize using a 10 MHz transducer, will produce faster extensive sensory block. Methods: One hundred twenty patients two equal groups: (S)...
The article reports on an experiment which investigated the effect of increased classroom ventilation rate performance children aged 10-12 years. was executed at two different schools (two classrooms each school) as a double-blind 2 × crossover intervention where four tests were used surrogates for short-term concentration and logical thinking. Only complete pairs test responses included in within-subject comparisons performance, data not corrected learning fatigue effects. Analysis total...
Background & AimsEosinophilic gastritis (EG) and eosinophilic duodenitis (EoD), characterized by chronic gastrointestinal (GI) symptoms increased numbers or activation of eosinophils mast cells in the GI tract, are likely underdiagnosed. We aimed to determine rates EG EoD number biopsies required optimize detection using screening data from a randomized trial lirentelimab (AK002), an antibody against siglec-8 that depletes inhibits cells. also endoscopic features EoD.MethodsSubjects with...
Allergic conjunctivitis (AC) is an ocular inflammatory disease with symptoms driven by eosinophils and mast cells. comorbidities are common. Current treatments often ineffective in severe AC limited potential side effects. Lirentelimab anti-sialic acid-binding immunoglobulin-like lectin-8 mAb that depletes inhibits
Patients with solid tumors, including carcinoma of the pancreas, express high levels matrix metalloproteinases (MMP), and these enzymes are believed to be important for growth, spread, dissemination most malignant tumors. Marimastat is first orally available MMP inhibitor (MMPI) tested in humans has been shown inhibit spread growth pancreatic cancer animal models. The purpose present study was define toxicities, safety, tolerance various doses marimastat also get an early indication...