A5012367335- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Autoimmune Bullous Skin Diseases
- Toxoplasma gondii Research Studies
- Intraocular Surgery and Lenses
- Urticaria and Related Conditions
- Ocular Oncology and Treatments
- Ocular Surface and Contact Lens
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Retinal and Macular Surgery
- Autoimmune and Inflammatory Disorders Research
- Ocular Infections and Treatments
- Bartonella species infections research
- IgG4-Related and Inflammatory Diseases
- Syphilis Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- Viral Infections and Vectors
- Drug-Induced Adverse Reactions
- Herpesvirus Infections and Treatments
- Allergic Rhinitis and Sensitization
- Autoimmune and Inflammatory Disorders
Massachusetts Eye Research and Surgery Institute
2009-2025
Ocular Immunology and Uveitis Foundation
2010-2024
New York Eye and Ear Infirmary
2012-2016
University of Illinois Chicago
2015-2016
Icahn School of Medicine at Mount Sinai
2009-2014
Tufts University
2007
Allergic conjunctivitis (AC) is an ocular inflammatory disease with symptoms driven by eosinophils and mast cells. comorbidities are common. Current treatments often ineffective in severe AC limited potential side effects. Lirentelimab anti-sialic acid-binding immunoglobulin-like lectin-8 mAb that depletes inhibits
Objective. To evaluate the outcome of tumor necrosis factor-α inhibition (anti-TNF) for pediatric uveitis. Methods. We retrospectively assessed children (age ≤ 18 yrs) with noninfectious uveitis receiving anti-TNF at 5 centers and 1 rheumatology center. Incident treatment success was defined as minimal or no activity ≥ 2 consecutive ophthalmological examinations 28 days apart while taking oral eyedrops/day corticosteroids. Eligible had active and/or were higher corticosteroid doses. Results....
Intraocular involvement in primary CNS lymphoma (PCNSL) is rare, and thus its natural history unclear. These authors retrospectively reviewed data
To compare the frequencies of attacks before and after immunomodulatory therapy (IMT) with mycophenolate mofetil (MMF) in recurrent punctate inner choroidopathy (PIC) to report fundus autofluorescence (FAF) findings.Eight patients who had at least two episodes increased activity MMF 12 months documented clinical course were included. The compared. FAF images evaluated.Before MMF, 8 experienced 19 disease activity; during therapy, 3 (38%) 6 episodes. attack 1.09 ± 0.75 0.23 0.32 treatment (p...
In Brief BACKGROUND: Dermatomyositis is rare during pregnancy and, if untreated, associated with poor fetal outcome. Corticosteroids are a standard treatment for dermatomyositis in pregnancy, but they have adverse effects. Intravenous immune globulin an effective therapy this condition and may few CASE: A young, white primigravida presented at 4 5/7 weeks of gestation (creatine kinase 2,762 units/L). was administered monthly dose 1 g/(kg·d) 2 consecutive days. The patient's symptoms resolved...
Purpose To evaluate the wide-field fundus fluorescein angiography (WFA) characteristics of uveitis associated with juvenile idiopathic arthritis (JIA-uveitis).Methods Retrospective review records. WFA Spectralis (Heidelberg) JIA-uveitis patients were analyzed using scoring system by Angiography Scoring for Uveitis Nomenclature.Results Thirty-seven eyes 20 studied. A total score at least 1 was noted in 27 (72.97%). features included optic disc hyperfluorescence (51.35%), macular leakage...
Adamantiades-Behçet's disease (ABD) is a multisystemic vasculitic disease. It most prevalent in the Eastern Mediterranean countries and region of Asia. Its effect on eye can range from mild to debilitating, resulting total blindness. A necrotizing obliterative vasculitis affects both arteries veins organs. Recurrent attacks uveitis, oral aphthous ulcers, skin lesions, genital ulcers are common. Topical systemic corticosteroids have been mainstay treatment ocular inflammation for many years;...
To report on a patient with congenital erythropoietic porphyria who presented scleral necrosis.Case report.A 34-year-old man long history of was referred to us for evaluation necrotizing scleritis the right eye. The 3-month duration eye pain and redness, which initially responded oral topical corticosteroids. However, upon corticosteroid taper, symptoms quickly recurred. tried azathioprine therapy, failed induce resolution symptoms. Full serological investigation did not suggest that...
To report a case of systemic and ocular toxoplasmosis in an immunocompetent patient, who developed myocarditis with resulting cardiogenic shock multiple organ failure, followed by bilateral panuveitis masquerading as endogenous endophthalmitis.Single images.A 59-year-old man history monoclonal gammopathy undetermined significance associated scleromyxedema but otherwise was admitted to the intensive care unit for failure due presumed viral myocarditis. After hospital discharge, ophthalmic...
To show whether subcutaneous repository corticotropin injection (RCI, Acthar® Gel, a injection, can be an effective potential therapeutic agent for noninfectious retinal vasculitis.
To search findings that can explain the heterogeneity between Resistant and Responsive patients with birdshot chorioretinopathy.This was a retrospective observational case series on "Responsive" versus "Resistant" chorioretinopathy.One-hundred-eighty Ninety-nine were included in groups respectively. Multivariate analysis of paraclinical variables at first visit demonstrated mean deviation (p = .04), pattern standard < .001), optic nerve head leakage .012), large vessel staining .01), macular...
Purpose: To evaluate the efficacy of intravenous methotrexate and methylprednisolone in severe, sight-threatening ocular inflammatory conditions.Methods: This was a retrospective observational case series. Patients who had received for inflammation with at least 24 months follow-up were included study.Results: Ten patients (20 eyes) this study. Mean age 47.2 ± 17.7 (range:19-74). At 1-month visit, nine showed improvement one patient failed treatment. 12-month all remission. Two only on...
Purpose To characterize various ocular inflammatory complications arising from metastatic cutaneous melanoma therapies and their management.Methods Retrospective case series of patients who were referred to a tertiary uveitis practice for ophthalmic exam All received targeted treatment, including BRAF/MEK inhibitors immunotherapies.Results 109 identified, with 43 (39.4%) having 65 definitive instances OIAE. Sixteen different OIAE identified. Ipilimumab monotherapy ipilimumab/nivolumab...