A5101551741- Autophagy in Disease and Therapy
- Intraocular Surgery and Lenses
- Tea Polyphenols and Effects
- Sirtuins and Resveratrol in Medicine
- Polysaccharides and Plant Cell Walls
- Traumatic Ocular and Foreign Body Injuries
- Ocular Diseases and Behçet’s Syndrome
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- CRISPR and Genetic Engineering
- Blood Pressure and Hypertension Studies
- Facial Trauma and Fracture Management
- Neurological Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Maternal and Perinatal Health Interventions
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Ginseng Biological Effects and Applications
- Neurological Disorders and Treatments
- Diabetes and associated disorders
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- RNA modifications and cancer
Soochow University
2021-2025
Second Affiliated Hospital of Soochow University
2023-2025
Chinese Academy of Fishery Sciences
2024
Wenzhou Medical University
2023-2024
University of Florida
2019-2023
UF Health Shands Hospital
2022-2023
Hunan University of Traditional Chinese Medicine
2023
Ocular Immunology and Uveitis Foundation
2023
Massachusetts Eye Research and Surgery Institute
2023
Florida College
2022-2023
Abstract Compelling evidences have revealed the emerging role of ferroptosis in pathophysiological process acute lung injury (ALI), but its modulation is not clear. Here, we identified that STAT6 acted as a critical regulator epithelium during ALI. Firstly, expression and activity were increased ALI mice models caused by crystalline silica (CS), LPS X-ray exposure. Followed confirming contribution above with ferrostatin-1 deferoxamine intervention, bioinformatic analyses was negatively...
Abstract Lipid metabolism, especially fatty acid oxidation (FAO) dysfunction, is a major driver of renal fibrosis; however, the detailed regulatory mechanisms involved remain unclear. In this study, we showed that there existed an association between signal transducer and activator transcription 6 (STAT6) tubular lipid metabolism in fibrotic kidneys. Specifically, STAT6 was activated along with accumulation lipids via downregulation FAO-related genes when mice were subjected to unilateral...
Probiotic lactobacilli and their exopolysaccharides (EPS) are thought to modulate mucosal homeostasis; however, mechanisms remain elusive. Thus, we tried clarify the role of from Lactobacillus plantarum NCU116 (EPS116) in intestinal homeostasis. Our results indicated that EPS116 regulated colon healing homeostasis, enhanced goblet cell differentiation, promoted expression Muc2 gene vivo vitro. Further experiments showed phosphorylation transcription factor c-Jun facilitated its binding...
Targeting autophagy and lysosome may serve as a promising strategy for cancer therapy. Tea polysaccharide (TP) has shown antitumor effects. However, its mechanism remains elusive. Here, TP was found to have significant inhibitory effect on the proliferation of colon line HCT116 cells. RNA-seq analysis showed that upregulated signal pathways, which further confirmed through experiments. Immunofluorescence experiments indicated activated transcription factor EB (TFEB), key nuclear modulating...
Despite the knowledge of many genetic alterations present in osteosarcoma, complexity this disease precludes placing its biology into a simple conceptual framework. Lysyl oxidase (LOX) catalyzes cross-linking elastin and collagen, which is essential for structural integrity function bone tissue. In current study, we performed genomic sequencing on all seven exons -including intron-exon splice sites, putative promoter region LOX gene - followed by luciferase reporter assay to analyze newly...
There is insufficient evidence to show that the guidelines' recommendations of physical activity (PA) are associated with long-term benefits in individuals hypertension.This prospective cohort study included UK Biobank participants hypertension. Time spent on vigorous-intensity PA (VPA), moderate-intensity (MPA), and light-intensity (LPA) measured by wrist-worn accelerometer were extracted. The primary outcomes major adverse cardiovascular events (including death, stroke, myocardial...
Realizing the potential of diketopyrrolopyrrole (DPP) heterocyclic scaffold as a dye or semiconductor in context molecular electronics, organic photovoltaics, and supramolecular chemistry requires understanding fully factors that drive its aggregation. To determine how solubilizing side chains, conjugation length, H‐bonding groups affect DPP assembly into J ‐aggregates, we performed variable temperature ultraviolet–visible titrations toluene on series derivatives. The structures these...
Abstract Objective To investigate the associations of tea, coffee, and red wine intakes with health risks among individuals hypertension. Methods This prospective cohort study included participants hypertension from UK Biobank cohort. Study exposures self-reported wine. The primary outcome was all-cause mortality, secondary outcomes were cardiovascular mortality disease. beverage intake analyzed using Cox regression models. hazard ratios 95% confidence intervals estimated. Results A total...
Cervical cancer poses a serious threat to women's health globally. Our previous studies found that upregulation of TM7SF2, which works as an enzyme involved in the process cholesterol biosynthesis expression, was highly correlated with cervical cancer. However, mechanistic basis TM7SF2 promoting progression via lipid metabolism remains poorly understood. Therefore, quantification fatty acids and droplets were performed vitro vivo. The protein-protein interaction verified by Co-IP technique....
Abstract Background The purpose of this study was to investigate the relationship between size and duration asymptomatic subchorionic hematoma pregnancy outcomes in women with singleton pregnancies. Methods This a retrospective that enrolled 701 pregnant who were diagnosed by ultrasound at 5–10 gestational weeks. control group recruited 640 normal without matched on baseline characteristics. compared two groups, associations analyzed logistic regression model. Results Compared group,...
The development of Ewing's sarcoma (ES) is a complex process, resulting from interplay between mutations in oncogenes and tumor suppressors, host susceptibility factors, cellular context. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays important roles downregulating the T-cell activation. Polymorphisms CTLA-4 gene have been shown to be associated with different autoimmune diseases cancers. current study evaluated association two polymorphisms, −318C/T (rs5742909) +49G/A (rs231775) ES Chinese...
As we all know, colon cancer is the third most prevalent in world and existing treatments have many negative effects. Our data indicated that tea polysaccharides induced lysosome-mediated mitochondrial apoptosis promoted cell death.
Purpose: Carboxymethylcellulose is an artificial tear ingredient known to decrease gut microbiome diversity when ingested. This study examines the effect of carboxymethylcellulose on ocular surface and composition. Methods: Healthy adult participants without significant ophthalmic disease or concurrent use were allocated randomly take control polyethylene glycol tears for seven days. Conjunctival swabs collected before after treatment. trial registered at clinicaltrials.gov (NCT05292755)....
The rates of twin pregnancies and cesarean section have increased in recent years, both them are at high risks postpartum hemorrhage (PPH). However, few studies concentrated on the PPH deliveries. In this study, we aimed to identify risk factors for among twin-pregnant women with section. This was a retrospective observational study including 1,649 delivered by from 2016 2022 Second Affiliated Hospital Wenzhou Medical University, China. eligible were divided into group (