A5018398740- IL-33, ST2, and ILC Pathways
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Kruppel-like factors research
- MicroRNA in disease regulation
- Birth, Development, and Health
- Genomics, phytochemicals, and oxidative stress
- Vitamin D Research Studies
- Pancreatic function and diabetes
- Immune cells in cancer
- RNA modifications and cancer
Soochow University
2021-2022
Abstract Compelling evidences have revealed the emerging role of ferroptosis in pathophysiological process acute lung injury (ALI), but its modulation is not clear. Here, we identified that STAT6 acted as a critical regulator epithelium during ALI. Firstly, expression and activity were increased ALI mice models caused by crystalline silica (CS), LPS X-ray exposure. Followed confirming contribution above with ferrostatin-1 deferoxamine intervention, bioinformatic analyses was negatively...
Crystalline silica (CS) is a universal environmental pollutant, which causes typical inflammatory lung injury. Vitamin D shows huge potential against particles-induced injury, while little known about the molecular mechanism involved in macrophage autophagy. In this study, we aim to identify protective effects of vitamin on CS caused injury and clarify detail mechanism. After exposure (3 mg/mice 50 μl PBS), wildtype Atg7flox/flox Lyz2-cre mice were treated with or without D3 (40,000 IU/kg)....
Nonylphenol (NP) is an endocrine disrupting chemical, which widely exists in environment and can result multiple system dysfunction. Pancreas as one of the most important organs sensitive to NP, while detail toxic effect still less studied. Previously, we unveiled nonylphenol causes pancreatic damage rats, herein, further explore potential mechanism seek protection strategy vitro. Insulinoma (INS-1) cells exposed NP were observed suffer oxidative stress mitochondrial dysfunction, reflected...
Lung inflammatory injury is a global public health concern. It characterized by infiltration of diverse cells and thickening pulmonary septum along with oxidative stress to airway epithelial cells. STAT6 nuclear transcription factor that plays crucial role in orchestrating the immune response, but its function tissue has not been comprehensively studied. Here, we demonstrated activation can protect against particle-induced lung resisting stress. Specifically, genetic ablation was observed...