A5069879069- Macrophage Migration Inhibitory Factor
- Traditional Chinese Medicine Studies
- Spaceflight effects on biology
- Ferroptosis and cancer prognosis
- Cardiac Fibrosis and Remodeling
- Agriculture Sustainability and Environmental Impact
- Complement system in diseases
- GDF15 and Related Biomarkers
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Galectins and Cancer Biology
- Healthcare and Venom Research
- Climate Change and Health Impacts
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Andrographolide Research and Applications
- Caveolin-1 and cellular processes
- Metabolism and Genetic Disorders
Soochow University
2021-2025
First Affiliated Hospital of Soochow University
2024-2025
Shenzhen University
2006
Abstract Lipid metabolism, especially fatty acid oxidation (FAO) dysfunction, is a major driver of renal fibrosis; however, the detailed regulatory mechanisms involved remain unclear. In this study, we showed that there existed an association between signal transducer and activator transcription 6 (STAT6) tubular lipid metabolism in fibrotic kidneys. Specifically, STAT6 was activated along with accumulation lipids via downregulation FAO-related genes when mice were subjected to unilateral...
622 Background: Cholangiocarcinoma (CCA) is a highly malignant biliary tumor characterized by frequent perineural invasion (PNI), which associated with poor prognosis; however, the underlying mechanisms remain unclear. G-protein-coupled receptor 120 (GPR120) has been implicated in development of various tumors, while nerve growth factor (NGF) strong correlation PNI. This study aims to elucidate role GPR120 production NGF and investigate PNI induced CCA. Methods: We conducted retrospective...
Background: Triggering receptor expressed on myeloid cells 2 (TREM2), a transmembrane immunoglobulin-superfamily receptor, is primarily such as macrophages and dendritic cells. TREM2 has been shown to be associated with diseases neurodegeneration, fatty liver, obesity, atherosclerosis. Currently, it become one of the hotspots in oncology research. However, role pan-cancer, especially pancreatic cancer, remains unclear. Methods: We used Tumor-immune System Interactions Database (TISIDB)...
Objective: 5-fluorouracil- and oxaliplatin-based FOLFOX regimens are mainstay chemotherapeutics for colorectal cancer (CRC) but drug resistance represents a major therapeutic challenge. To improve patient survival, there is need to identify genes better understand the mechanisms underlying chemotherapy resistance. Methods: Transcriptomic datasets were retrieved from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases combined with our own microarray data. Weighted gene...
Tim-1 (T-cell immunoglobulin and mucin domain 1), also known as Kim-1 (kidney injury molecule 1) or hepatitis A virus cellular receptor 1 (HAVCR1), is a transmembrane protein expressed on various immune epithelial cells. It plays role in modulating inflammatory responses. In this study, we find that overexpressed hepatocellular carcinoma (HCC) samples its expression significantly correlated with postoperative survival. Bulk RNA sequencing reveals general upregulation of extracellular...
Hepatocellular carcinoma (HCC), a globally prevalent form of cancer, is featured by aggressive growth and early metastasis. Elucidating the underlying mechanism identifying effective therapy are critical for advanced HCC patients. In study, we detect that KRT80 was upregulated in samples. patients with higher associated worse overall survival after surgery. Gain-of loss-of function studies show enhanced cells proliferation, migration, invasion, angiogenesis, whereas its silencing abolishes...
High mortality and morbidity rates associated with ST-elevation myocardial infarction (STEMI) post-STEMI heart failure (HF) necessitate proper risk stratification for coronary artery disease (CAD). A prediction model that combines specificity convenience is highly required. This study aimed to design a monocyte-based gene assay predicting STEMI HF. total of 1,956 monocyte expression profiles corresponding clinical data were integrated from multiple sources. Meta-results obtained through the...