A5101420271- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Renal Transplantation Outcomes and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Hemoglobinopathies and Related Disorders
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Gout, Hyperuricemia, Uric Acid
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Synthesis and Characterization of Heterocyclic Compounds
- Pneumocystis jirovecii pneumonia detection and treatment
- Biomedical Research and Pathophysiology
- Synthesis and biological activity
- Cancer, Hypoxia, and Metabolism
- Immunodeficiency and Autoimmune Disorders
- Sulfur Compounds in Biology
Hunan Normal University
2023-2025
Soochow University
2015-2025
First Affiliated Hospital of Soochow University
2015-2025
Hunan Provincial Center for Disease Control and Prevention
2025
Changsha Hospital for Maternal and Child Health Care
2017-2025
Central South University
2008-2025
Hunan Agricultural University
2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Guangzhou Institutes of Biomedicine and Health
2024
A series of novel myricetin derivatives containing a 1,2,4-triazole Schiff base were designed and synthesized. Their structures systematically characterized using 1H NMR, 13C HRMS. During antibacterial bioassays, 6f, 6i, 6q demonstrated good inhibitory effect against Xanthomonas axonopodis pv. citri (Xac), with half-maximal effective concentration (EC50) values 10.0, 9.4, 8.8 μg mL-1, respectively, which better than those bismerthiazol (54.9 mL-1) thiodiazole copper (61.1 mL-1). Note that 6w...
Abstract Background The differential diagnoses of patients hospitalized for respiratory infections due to influenza virus vs other pathogens are challenging. Our study investigated whether hematological parameters such as neutrophil (N), lymphocyte (L), platelet (PLT), and neutrophil‐to‐lymphocyte ratio (NLR) contributed in diagnosing discriminating infections. Methods We retrospectively analyzed the laboratory characteristics 307 with caused by influenza/non‐influenza bacteria. diagnostic...
A series of novel chalcone derivatives containing the 1,2,4-triazine moiety were synthesized and their structures confirmed by<sup>1</sup>H NMR,<sup>13</sup>C NMR elemental analyses.
Abstract BACKGROUND Myricetin and sulfonamide derivatives exhibited a wide variety of biological activity. In order to develop highly bioactive molecules, novel myricetin containing moiety were synthesized antibacterial activities investigated. RESULTS The results bioassays indicated that compound A12 , having an EC 50 value 4.7 μg mL −1 the best in vitro against Xanthomonas oryzae pv. ( X. o .); values for this even better than those thiodiazole‐copper (TC, 71.4 ) bismerthiazol (BT, 54.7 )....
Abstract Background The aim is to evaluate the clinical utility of a long-read sequencing-based approach termed comprehensive analysis thalassemia alleles (CATSA) in prenatal diagnosis thalassemia. Methods A total 278 fetuses from at-risk pregnancies identified carrier screening by PCR-based methods were recruited 9 hospitals, and employed for diagnosis. CATSA was performed retrospectively blindly all fetuses. Results Among fetuses, 263 (94.6%) had concordant results 15 (5.4%) discordant...
The aim of the study was to evaluate predictive value preoperative high-sensitive C-reactive protein/albumin (hs-CRP/Alb) ratio in systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL).We retrospectively reviewed 556 patients who underwent PCNL at our institution between August 2015 and February 2018. primary endpoint for development SIRS operation. A univariate multivariate logistic regression analysis used identify independent factors associated with...
A series of novel chalcone derivatives containing a thiophene sulfonate group were designed and synthesized. The structures all title compounds determined by 1H-NMR, 13C-NMR HRMS. Antibacterial bioassays indicated that, compound 2l demonstrated excellent antibacterial activities against Xanthomonas axonopodis pv. citri (Xac), with an EC50 value 11.4 μg mL-1, which is significantly superior to those bismerthiazol (BT) (51.6 mL-1) thiodiazole-copper (TC) (94.7 mL-1). Meanwhile, the mechanism...
A series of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety were synthesized, and their bioactivities action mechanism evaluated.
T-2 toxin is a trichothecene mycotoxin of significant danger to humans and animals. Its impact on reproductive toxicity attributed oxidative stress, which ultimately leads cell death. Ferroptosis programmed death that characterized by lipid peroxidation. This study aimed investigate the toxic effects mouse testis potential mechanism toxin-induced ferroptosis. significantly altered morphology decreased testosterone level, sperm concentration, increased malformation rate, as well induced...
Hepatocellular carcinoma (HCC) is the most prevalent liver cancer and a leading cause of cancer-related deaths worldwide. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) plays critical role in RNA metabolism, including alternative splicing, which linked to progression. Our study investigated hnRNPA1 HCC its potential as therapeutic target. We analyzed expression tissues compared non-tumor using RNA-seq immunohistochemistry. was knocked down Hep G2 cells assess impact on cell...
Persistent infection with high-risk human papillomavirus (HPV) is a significant risk factor for cervical cancer. HPV typing and cytology are conducted in women of appropriate age to assess the lesions guide need further diagnostic procedures such as colposcopy, biopsy, or treatment. This article explores methods predict risks high-grade precancerous based on typing. We retrospective analysis data from 158,565 women, including 19,707 who underwent ThinPrep cytologic testing (TCT), 7,539 had...
622 Background: Cholangiocarcinoma (CCA) is a highly malignant biliary tumor characterized by frequent perineural invasion (PNI), which associated with poor prognosis; however, the underlying mechanisms remain unclear. G-protein-coupled receptor 120 (GPR120) has been implicated in development of various tumors, while nerve growth factor (NGF) strong correlation PNI. This study aims to elucidate role GPR120 production NGF and investigate PNI induced CCA. Methods: We conducted retrospective...
Abstract Background Screening of malignant hematological diseases is great importance for their diagnosis and subsequent treatment. This study constructed an optimal screening model based on routine blood cell parameters. Methods The venous samples 1751 patients collected from 10 tertiary hospitals in China were divided into a training set (1223 cases) validation (528 cases). In addition to the clinical diagnostic information set, 26 parameters including morphological selected using manual...
Abstract Subarachnoid hemorrhage (SAH) can lead to significant acute neuroinflammation, with treatment outcomes often being inadequate. Olfactory mucosa mesenchymal stem cells (OM‐MSCs) have promising therapeutic potential in nerve regeneration and functional recovery. This investigation sought elucidate the mechanisms through which exosomes derived from OM‐MSCs provide protection against neuroinflammation following SAH. Mouse their were isolated characterized using various techniques,...
Objective: This study aims to comprehensively investigate the expression profiles of interleukins in prostate adenocarcinoma (PRAD) and their relationship with immune cell infiltration, tumor progression, patient prognosis. By establishing an interleukin-related risk score, we seek enhance understanding microenvironment facilitate development tailored immunotherapeutic strategies for PRAD patients. Introduction: Interleukins can nurture a promoting environment simultaneously regulate...