A5100394388- Lung Cancer Treatments and Mutations
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Pulmonary Hypertension Research and Treatments
- Peroxisome Proliferator-Activated Receptors
- Cancer-related Molecular Pathways
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- CRISPR and Genetic Engineering
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Acute Kidney Injury Research
- Alzheimer's disease research and treatments
Chinese Academy of Sciences
2018-2025
Guangzhou Institutes of Biomedicine and Health
2022-2025
Guangzhou Medical University
2022-2025
University of Chinese Academy of Sciences
2018-2025
China Three Gorges University
2025
Shanghai Institute of Materia Medica
2018-2024
Peking University Third Hospital
2017-2024
Peking University
2005-2024
Case Western Reserve University
2023-2024
Qinghai University
2023-2024
Wounds represent a grave affliction that profoundly impacts human well-being.Establishing barriers, preventing infections, and providing conducive microenvironment constitute the crux of wound therapy.Hydrogel, polymer with an intricate three-dimensional lattice, serves as potent tool in erecting physical barriers nurturing environment to healing.This enables effective control over exudation, hemostasis, accelerated closure, diminished scar formation.As result, hydrogels have gained...
Neutrophil Extracellular Traps (NETs), a web-like structure of cytosolic and granule proteins assembled on decondensed chromatin, kill pathogens causes tissue damage in diseases. Whether NETs can cancer cells is unexplored. Here, we report that combination glutaminase inhibitor CB-839 5-FU inhibits the growth PIK3CA mutant colorectal cancers (CRCs) xenograft, syngeneic, genetically engineered mouse models part through NETs. Disruption by either DNase I treatment or depletion neutrophils CRCs...
The chicken is an important agricultural animal and model for developmental biology, immunology virology. Excess fat accumulation continues to be a serious problem the industry. However, adipogenesis obesity have not been well investigated, because no preadipocyte cell lines generated thus far. Here, we successfully two immortalized through transduction of either telomerase reverse transcriptase (chTERT) alone or in combination with RNA (chTR). Both these survived >100 population doublings...
Monitoring the appearance and progression of tumors are important for improving survival rate patients with ovarian cancer. This study aims to examine circulating tumor cells (CTCs) in epithelial cancer (EOC) evaluate their clinical significance comparison existing biomarker CA125.Immuomagnetic bead screening, targeting antigens on cells, combined multiplex reverse transcriptase-polymerase chain reaction (Multiplex RT-PCR) was used detect CTCs 211 samples peripheral blood (5 ml) from 109 EOC...
Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii Hook f, which displays potential anticancer activity. In present study, we investigated effects of celastrol against clear cell renal carcinoma (ccRCC) and underlying mechanisms. Using Cancer Genome Atlas (TCGA) database genotype-tissue expression (GTEx) conducted bioinformatics analysis, showed that mRNA levels liver-X receptors α (LXRα) ATP-binding cassette transporter A1 (ABCA1) in ccRCC tissues...
Hypoxia-inducible factor (HIF) is critical in the modulation of tumour angiogenesis response to hypoxia. In present study, mechanisms underlying basic fibroblast growth (bFGF)-induced activation HIF-1 and subsequent release vascular endothelial (VEGF) a human breast cancer cell line (T47D) under normoxic conditions were explored. The data show that HIF-1α expression induced by bFGF dose- time-dependent fashion, while increased protein transactivity are due phosphorylation Akt bFGF, as...
Abstract Background Excessive accumulation of lipids in the adipose tissue is a major problem present-day broiler industry. However, few studies have analyzed expression genes that are involved pathways and mechanisms leading to adiposity chickens. Gene profiling chicken could provide key information about ontogenesis fatness clarify molecular underlying obesity. In this study, Chicken Genome Arrays were used construct an gene profile 7-week-old broilers, screen differentially expressed lean...
In addition to providing energy and constituting cell membrane, fatty acids also play an important role in adipocyte differentiation lipid metabolism. As member of monounsaturated acids, oleate, together with other components, is widely used induce chicken preadipocyte differentiation. However, it not clear whether oleate alone can the present study, four different treatments were designed test this question: basal medium, IDX [insulin, dexamethasone IBMX (isobutylmethylxanthine)], plus...
Significance Estrogen exposure is the major risk factor for diseases of endometrium such as endometriosis and endometrial cancer. This thought to be through its constant stimulation epithelial cell proliferation. Progesterone blocks estrogen-induced proliferation it mitigates these diseases. However endometriotic tissue cancer become progesterone resistant. Here we identify an estrogen induced pathway in uterine cells that activates protein synthesis mechanistic target rapamycin (mTOR) a...
Cordycepin (3 -deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species fungal genus Cordyceps.It has traditionally been prized Chinese folk medicine for human well-being.However, actions cordycepin against renal ischemia/reperfusion injury (I/R) are still unknown.In present study, rats were subject to I/R was intragastrically administered seven consecutive days before surgery investigate effects mechanisms...
Abstract Although extended pluripotent stem cells (EPSCs) have the potential to form both embryonic and extraembryonic lineages, how their transcriptional regulatory mechanism differs from that of (ESCs) remains unclear. Here, we discovered YY1 binds specific open chromatin regions in EPSCs. Yy1 depletion EPSCs leads a gene expression pattern more similar ESCs than control Moreover, triggers series epigenetic crosstalk activities, including changes DNA methylation, histone modifications...
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an extracellular enzyme responsible for hydrolyzing cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), the endogenous agonist stimulator of interferon genes (STING) pathway. Inhibition ENPP1 can trigger STING and promote antitumor immunity, offering attractive therapeutic target cancer immunotherapy. Despite progress in discovery inhibitors, diversity chemical structures efficacy agents are far from desirable,...
Cyclin-dependent kinases (CDK) 14 regulates cell cycle, tumor expansion by influencing the downstream targets of canonical Wnt signaling pathway. However, function CDK14 during organ development and regeneration has not been investigated in genetically-modified animals. Here, we found that genetic ablation Cdk14 influenced pulmonary vascular endothelial cells alveolar epithelial mice embryonic as well repair lung after bleomycin or lipopolysaccharide induced injury. Genetic knockout covalent...
Persistent infection with high-risk human papillomavirus (HPV) is a significant risk factor for cervical cancer. HPV typing and cytology are conducted in women of appropriate age to assess the lesions guide need further diagnostic procedures such as colposcopy, biopsy, or treatment. This article explores methods predict risks high-grade precancerous based on typing. We retrospective analysis data from 158,565 women, including 19,707 who underwent ThinPrep cytologic testing (TCT), 7,539 had...
The TBX2 subfamily of T-box transcription factors (including Tbx2, Tbx3, Tbx4, Tbx5) plays an essential role in lung development. Downregulation these genes human Lung adenocarcinoma (LUAD) suggests that may be tumor suppressive, however because downregulation appears to occur primarily via epigenetic change, it remains unclear if changes causally drive progression or are merely the consequence upstream events. Herein, we developed first multiplexed mouse model study impact loss, alongside...
Purpose To evaluate the utility of histogram analysis monoexponential, biexponential, and stretched‐exponential models to a dualistic model epithelial ovarian cancer (EOC). Materials Methods Fifty‐two patients with histopathologically proven EOC underwent preoperative magnetic resonance imaging (MRI) (including diffusion‐weighted [DWI] 11 b‐values) using 3.0T system were divided into two groups: types I II. Apparent diffusion coefficient (ADC), true (D), pseudodiffusion (D*), perfusion...
Xanthine dehydrogenase (XDH) is the rate-limiting enzyme in purine catabolism by converting hypoxanthine to xanthine and uric acid.The altered expression activity of XDH are associated with development prognosis multiple types cancer, while its role lung adenocarcinoma (LUAD) remains unknown.Herein, we demonstrated that was highly expressed LUAD significantly correlated poor prognosis.Though inhibition displayed moderate effect on viability cells cultured complete medium, it attenuated...