A5089423911- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Enzyme Structure and Function
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Viral Infections and Immunology Research
- RNA modifications and cancer
- Diet, Metabolism, and Disease
- Silk-based biomaterials and applications
- Air Quality and Health Impacts
- Enzyme Production and Characterization
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- RNA regulation and disease
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Innovations in Medical Education
- 2D Materials and Applications
- Climate Change and Health Impacts
- Galectins and Cancer Biology
- Calcium Carbonate Crystallization and Inhibition
- Diabetic Foot Ulcer Assessment and Management
- IL-33, ST2, and ILC Pathways
- Pressure Ulcer Prevention and Management
University of Iowa
2025
Sichuan University
2022-2024
Tianjin University of Technology
2024
China Academy of Chinese Medical Sciences
2024
Institute of Zoology
2024
Chinese Academy of Sciences
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
University of Chinese Academy of Sciences
2017-2024
Wuhan Textile University
2024
Mudanjiang Medical University
2023-2024
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research development vaccines, diagnostics therapeutics against by comprehensive collection influenza-related data integrated from various sources, growing suite analysis visualization tools mining hypothesis generation, personal workbench spaces...
Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) even optimal medical care. An increase of PM2.5 10 μg per cubic meter was associated a 76% in risk death from cardiovascular disease 4 years' period. However, role and mechanism progression are not known. Here we investigated exposure mice existing produced by transverse aortic constriction (TAC)....
Abstract Driving endogenous bone regeneration by cell‐ and factor‐free biomaterials is the most ideal repair strategy. Herein, hybrid interleaved scaffold (HDSH) with nanosized interfacial integration assembled organic/inorganic interactive bonding at nanoscale. With help of transcriptome proteome analysis, regenerative mechanism this elaborated molecular level, which confirms that strategy recreates a suitable immune microenvironment (anti‐inflammatory M2‐polarizing) drives functional cell...
Abstract Nanostructured biomaterials that replicate natural bone architecture are expected to facilitate regeneration. Here, nanohydroxyapatite (nHAp) with vinyl surface modification is acquired by silicon‐based coupling agent and photointegrated methacrylic anhydride‐modified gelatin manufacture a chemically integrated 3D‐printed hybrid scaffold (75.6 wt% solid content). This nanostructured procedure significantly increases its storage modulus 19.43‐fold (79.2 kPa) construct more stable...
Abstract Bone regenerative scaffolds with a bionic natural bone hierarchical porous structure provide suitable microenvironment for cell migration and proliferation. Here, scaffold (DP‐PLGA/HAp) directional microchannels is prepared by combining 3D printing freezing technology. The printed framework provides structural support new tissue growth, while the pore embedded in an express lane nutrition transport, facilitating growth differentiation. achieve rapid infiltration adhesion of marrow...
Structural and physiological cues provide guidance for the directional migration spatial organization of endogenous cells. Here, a microchannel scaffold with instructive niches is developed using circumferential freeze-casting technique an alkaline salting-out strategy. Thereinto, polydopamine-coated nano-hydroxyapatite employed as functional inorganic linker to participate in entanglement crystallization chitosan molecules. This orchestrates advantage oriented porous structure rapid cell...
The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α (eIF2α) kinase, impairs the ventricular adaptation to chronic pressure overload affecting apoptosis. However, impact GCN2 on Dox-induced cardiotoxicity has not been investigated. In present study, treated wild type (WT) Gcn2-/- mice with four...
Seeking high biological activity and osteoinductive ability has always been an urgent problem for three-dimensional-printed (3DP) bony implants. Here, a 3DP methacrylic anhydride-modified gelatin (GelMA)/hydroxyapatite (HAp) scaffold with solid content of 82.5% was prepared anchored by functionalized polyphenol hydrogel. The hydrogel were organically integrated into bioinspired implant (HGH) phenolic hydroxyl hyaluronan derivatives conjugating amino groups collagen I GelMA further chelating...
Abstract Integrating a biomimetic extracellular matrix to improve the microenvironment of 3D printing scaffolds is an emerging strategy for bone substitute design. Here, “soft–hard” implant (BM‐g‐DPCL) consisting bioactive chemically integrated on polydopamine (PDA)‐coated porous gradient scaffold by polyphenol groups constructed. The PDA‐coated “hard” promoted Ca 2+ chelation and mineral deposition; “soft” beneficial migration, proliferation, osteogenic differentiation stem cells in vitro,...
Collagen-based hydrogels have a significant impact on wound healing, but they suffer from structural instability and bacterial invasion in infected wounds. Here, electrospun nanofibers of esterified hyaluronan (HA-Bn/T) are developed to immobilize the hydrophobic antibacterial drug tetracycline by π-π stacking interaction. Dopamine-modified HA-Bn/T employed simultaneously stabilize structure collagen-based hydrogel chemically interweaving collagen fibril network decreasing rate degradation....
Poor skin wound healing, which is common in patients with diabetes, related to imbalanced macrophage polarization. Here, we find that nutrition sensor GCN2 (general control nonderepressible 2) and its downstream are significantly upregulated human tissue mouse macrophages, but wound-related expression activity downregulated by diabetes hyperglycemia. Using healing models of GCN2-deleted mice, bone marrow chimeric monocyte-transferred show deletion macrophages delays compared wild-type mice...
Human enterovirus 71 (EV71) is the main causative pathogen of hand, foot, and mouth disease (HFMD) in children. The epidemic HFMD has been a public health problem Asia-Pacific region for decades, no vaccine effective antiviral medicine are available. Curcumin used as traditional centuries to treat diversity disorders including viral infections. In this study, we demonstrated that curcumin showed potent effect again EV71. Vero cells infected with EV71, addition significantly suppressed...
Designing a smart hydrogel to accelerate skin tissue regeneration at wound sites and restoring the function is highly desirable in clinical applications.
Skin has a protein microenvironment dominated by functional collagen fibers, while oxidative stress caused injury can greatly slow down the progress of wound healing. Here, methacrylated dopamine was incorporated into silk fibroin molecule chains to develop an injectable hydrogel with photocuring properties for constructing antioxidant skin microenvironment. This fibroin-based (SF-
The potential of nanoparticles as effective drug delivery tools for treating failing hearts in heart failure remains a challenge. Leveraging the rapid infiltration neutrophils into infarcted after myocardial infarction (MI), we developed nanoparticle platform engineered with neutrophil-membrane proteins targeted TAPI-1, TACE/ADAM17 inhibitor, to inflamed myocardium, aiming treat cardiac dysfunction and remodeling rats MI. Neutrophil-mimic liposomal (Neu-LNPs) were constructed by integrating...
Stress granules (SGs) are granular aggregates in the cytoplasm that formed under a variety of stress situations including viral infection. Previous studies indicate poliovirus, member Picornaviridae, can induce SG formation. However, exact mechanism by which picornaviruses formation is unknown. The localization markers cells infected with coxsackievirus B3 (CVB3) or enterovirus 71 (EV71) and expressing each protein was determined via immunofluorescence assays plasmid transfection. Eight...
The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide indicates the urgent need to develop novel and effective treatment strategies. Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has an outstanding effect in improving metabolism. However, pharmacological action mechanism BA NAFLD remain unclear. Here, we show that BA-treated high-fat diet mice methionine-choline deficient diet-fed are resistant hepatic steatosis when compared...
Abstract Background Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM ) pollution is associated the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary disease. In patients those circulating asymmetric dimethylarginine (ADMA) levels are increased, which contributes to airway nitric oxide deficiency, oxidative stress inflammation. Overexpression dimethylaminohydrolase 1 (DDAH1), an enzyme degrading ADMA, exerts protective...