A5026015949- Medical Image Segmentation Techniques
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Advanced Neural Network Applications
- Medical Imaging Techniques and Applications
- Cardiac Valve Diseases and Treatments
- 3D Shape Modeling and Analysis
- Medical Imaging and Analysis
- RNA Research and Splicing
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
- Image and Object Detection Techniques
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Generative Adversarial Networks and Image Synthesis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- DNA Repair Mechanisms
- Anatomy and Medical Technology
- Cardiac Arrhythmias and Treatments
- Ubiquitin and proteasome pathways
China National Petroleum Corporation (China)
2025
First Affiliated Hospital of Bengbu Medical College
2022-2024
Shanghai First Maternity and Infant Hospital
2016-2024
Wannan Medical College
2024
Shanghai Jiao Tong University
2023
Tencent (China)
2019-2021
KLA (United States)
2020
Changchun University
2020
Changchun University of Chinese Medicine
2020
Beijing Jiaotong University
2018-2019
Methods: Our deep learning model, called AnatomyNet, segments OARs from head and neck CT images in an end-to-end fashion, receiving whole-volume HaN as input generating masks of all interest one shot. AnatomyNet is built upon the popular 3D U-net architecture, but extends it three important ways: 1) a new encoding scheme to allow auto-segmentation on instead local patches or subsets slices, 2) incorporating squeeze-and-excitation residual blocks layers for better feature representation, 3)...
Somatic mutations of DNMT3A gene have recently been reported in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We examined the entire coding sequences by high-resolution melting analysis sequencing Chinese patients with malignancies. R882 were found 12/182 AML 4/51 MDS, but not either 79 chronic (CML), or 57 myeloproliferative neoplasms (MPNs), 4 monomyelocytic leukemia. No other detected all patients. associated old age more frequently present monoblastic (M4 M5, 7/52)...
In this work, we propose to resolve the issue existing in current deep learning based organ segmentation systems that they often produce results do not capture overall shape of target and lack smoothness. Since there is a rigorous mapping between Signed Distance Map (SDM) calculated from object boundary contours binary map, exploit feasibility SDM directly medical scans. By converting task into predicting an SDM, show our proposed method retains superior performance has better smoothness...
The fracture-cavity carbonate reservoir in Tahe oilfield is buried deep (more than 5000 m). has low permeability, strong heterogeneity, large size, diverse forms of connectivity, and complex spatial distribution. In conventional water flooding, it difficult to improve oil recovery effectively because small flood sweep injection pressure. Pressure flooding a new technique that can change the pore space. Combined with an displacement agent, pressure expected rate reservoirs. this paper,...
Purpose Radiation therapy (RT) is a common treatment for head and neck (HaN) cancer where therapists are often required to manually delineate boundaries of the organs-at-risks (OARs). The radiation planning time-consuming as each computed tomography (CT) volumetric data set typically consists hundreds thousands slices needs be individually inspected. Automated anatomical segmentation provides way speed up improve reproducibility planning. Previous work on primarily based atlas registrations,...
Abstract The NAD+-dependent deacetylase and mono-ADP-ribosyl transferase SIRT6 stabilizes the genome by promoting DNA double strand break repair, thereby acting as a tumor suppressor. However, whether regulates nucleotide excision repair (NER) remains unknown. Here, we showed that was recruited to sites of UV-induced damage stimulated damage. Mechanistic studies further indicated interacted with DDB2, major sensor initiating global NER (GG-NER), interaction enhanced upon UV irradiation....
Traditionally, straggering the primaries of double-sided permanent magnet linear synchronous motor (DS-PMLSM) is beneficial in helping to reduce detent force caused by longitudinal end effect, but leading a reduction average thrust. To overcome this disadvantage, paper provides novel DS-PMLSM, which adopts structure staggering two and rearranging windings. First, characteristics voltage are analyzed theoretically verified finite element (FEM) simulations. The inductance, thrust, normal...
The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide indicates the urgent need to develop novel and effective treatment strategies. Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has an outstanding effect in improving metabolism. However, pharmacological action mechanism BA NAFLD remain unclear. Here, we show that BA-treated high-fat diet mice methionine-choline deficient diet-fed are resistant hepatic steatosis when compared...
Abstract Cellular reprogramming is an emerging strategy for delaying the aging processes. However, a number of challenges, including impaired genome integrity and decreased pluripotency induced pluripotent stem cells (iPSCs) derived from old donors, may hinder their potential clinical applications. The longevity gene, Sirtuin 6 (SIRT6), functions in multiple biological processes such as maintenance regulation somatic cell reprogramming. Here, first time, we demonstrate that MDL‐800, recently...
To overcome the disadvantage that detent force of permanent magnet linear synchronous motor (PMLSM) with short primary is large, a scheme modular PMLSM flux barriers proposed in this paper. First, model established and verified. The phase-angle characteristics harmonics waveforms are analyzed. Then, design principles different sectional combinations analyzed, two series demonstrated. thrust these subsequently compared. In addition, to improve density, auxiliary teeth set at ends cores...
Ribonucleotide reductase regulatory subunit M2 (RRM2) has been reported to be an oncogene in some malignant tumors, such as lung adenocarcinoma, oral squamous cell carcinoma, glioblastoma, and breast cancer. However, the clinical significance of RRM2 hepatocellular carcinoma less studied. The aim this study was assess importance (HCC) based on Cancer Genome Atlas (TCGA) database.The expression levels features were downloaded from TCGA database. Immunohistochemistry results between tumor...
In this paper, we present a novel method for automatically extracting the tagging sheets in tagged cardiac MR images, and tracking their displacement during heart cycle, using tunable 3D Gabor filter bank. Tagged MRI is non-invasive technique study of myocardial deformation. We design bank based on geometric characteristics sheets. The parameters are used to adapt myocardium whole image dataset convolved with each bank, Fourier domain. Then impose set deformable meshes onto extracted track...
Hotspot mutations of serine/arginine-rich splicing factor 2 (SRSF2) gene have been identified in a proportion hematologic malignancies including myelodysplastic syndrome (MDS). The aim the present study was to develop new approach screen SRSF2 mutation and analyze clinical relevance Chinese MDS. A protocol based on high-resolution melting analysis (HRMA) established SRSF2-P95 108 MDS patients compared with Sanger sequencing. further evaluated. HRMA five (4.6%) cases mutation, completely...
Colorectal cancer (CRC) is one of the most frequently occurring primary malignant tumors worldwide. Chemotherapeutic resistance a major clinical problem in treatment CRC. Therefore, it great importance to investigate novel biomarkers that may predict chemoresistance and facilitate development individualized for patients with The present study reported let-7f-5p expression was elevated chemotherapy-resistant CRC tissues compared chemotherapy-sensitive tissues. Furthermore, upregulating...
This paper describes a new method for the automated segmentation and extraction of cardiac MRI tagging lines. Our is based on novel use 2D Gabor filter bank. By convolving tagged input image with our filters, lines are automatically enhanced segmented out. We design bank image's spatial frequency characteristics. The final result combination each filter's response in demonstrate that compared to bandpass methods such as HARP, this results robust accurate
Abstract Background DNA-damage-inducible transcript 3 ( DDIT3 ), a candidate tumor suppressor gene (TSG), has been found involved in the regulation of cellular growth and differentiation. The epigenetic changes TSGs are recently recognized as an abnormal mechanism contributing to development chronic myeloid leukemia (CML). aim this study was investigate methylation status CML patients. Methods promoter detected bone marrow mononuclear cells from 53 patients with using methylation-specific...