A5004754997- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Cultural Heritage Management and Preservation
- RNA regulation and disease
- Cardiac Fibrosis and Remodeling
- Cancer Cells and Metastasis
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Bacterial Genetics and Biotechnology
- Fuel Cells and Related Materials
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Cellular Mechanics and Interactions
- Viral Infections and Immunology Research
- Liver physiology and pathology
University of Rochester
2017-2025
Hunan Normal University
2025
Yangtze University
2024
Shaoguan University
2024
Chengdu University
2024
Cardiovascular Institute Hospital
2024
Sichuan University
2024
Hohai University
2023
Beijing Forestry University
2023
Cleveland Clinic Lerner College of Medicine
2008-2020
// Dong Ren 1, 2, * , Bihua Lin Xin Zhang 3 Yao Peng 4 Ziyu Ye 1 Yan Ma Yangfang Liang 5 Longbin Cao Xiangyong Li Ronggang Lixia Sun Qiongru Liu Jinhua Wu 6 Keyuan Zhou and Jincheng Zeng Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Bioactive Research for Department Education Province, University, Dongguan, 523808, China 2 Orthopedic Surgery, The First Affiliated Hospital Yat-Sen Guangzhou, 510080, Pathology, Jiangmen Central Hospital, Jiangmen, 529030,...
Increased protein synthesis of profibrotic genes is a common feature in cardiac fibrosis and heart failure. Despite this observation, critical factors molecular mechanisms for translational control during remain unclear.To investigate the role bifunctional ARS (aminoacyl-tRNA synthetase), EPRS (glutamyl-prolyl-tRNA synthetase) fibrosis.Results from reanalyses multiple publicly available data sets human mouse failure, demonstrated that acted as an integrated node among ARSs various pathogenic...
Abstract IL-17, a major inflammatory cytokine plays critical role in the pathogenesis of many autoimmune diseases. In this study, we report new function RNA-binding protein HuR IL-17–induced Act1-mediated chemokine mRNA stabilization. deficiency markedly reduced expression due to increased decay. polyubiquitination was required for binding CXCL1 mRNA, leading Although IL-17 induced coshift Act1 and polysomal fractions sucrose gradient, ratio translation-active/translation-inactive mRNAs....
Background: Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation the diseased heart. However, disease are largely uncharacterized. The current study aimed to investigate regulation function cardiac cells progression remodeling dysfunction. Methods: We used isolated adult mouse...
Accumulating evidence suggests that posttranscriptional control of gene expression, including RNA splicing, transport, modification, translation and degradation, primarily relies on binding proteins (RBPs). However, the functions many RBPs remain understudied. Here, we characterized function a novel RBP, Proline-Rich Coiled-coil 2B (PRRC2B). Through photoactivatable ribonucleoside-enhanced crosslinking immunoprecipitation sequencing (PAR-CLIP-seq), identified transcriptome-wide CU- or...
Cell regulatory circuits integrate diverse, and sometimes conflicting, environmental cues to generate appropriate, condition-dependent responses. Here, we elucidate the components mechanisms driving a protein-directed RNA switch in 3'UTR of vascular endothelial growth factor (VEGF)-A. We describe novel HILDA (hypoxia-inducible hnRNP L-DRBP76-hnRNP A2/B1) complex that coordinates three-element switch, enabling VEGFA mRNA translation during combined hypoxia inflammation. In addition binding...
BEST1 is a Ca2+-activated Cl- channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations the gene have been identified to cause degenerative disorders generally known as bestrophinopathies. As most are autosomal dominant, it of great biomedical interest determine their disease-causing mechanisms therapeutic potential therapy. Here, we characterized six Best vitelliform macular dystrophy (BVMD)-associated dominant by documenting patients' phenotypes,...
Inherited glycosylphosphatidylinositol deficiency disorders (IGDs) are a group of rare recessive genetic conditions characterised by developmental delays and an early onset epilepsy caused disruptions in the glycosylphosphatidylinositol-anchored biosynthetic pathway. In this study, we identified eight variants phosphatidyl inositol glycan (PIG) genes from four IGDs families through whole-exome sequencing (WES). The included one PIGA, two PIGW five PIGN, with being novel variants. Functional...
Abstract Background When pigs underwent apical resection (AR) on postnatal day (P) 1 (ARP1) followed by myocardial infarction (MI) P28, the hearts had little evidence of scarring; meanwhile, MI P28 without ARP1 showed large infarcts P56; and improvement was driven primarily cardiomyocyte proliferation. AR were performed ~5 mm ~20 above heart apex; thus, we hypothesize that preserved cardiomyocytes cell-cycle throughout left ventricle, rather than only near site. Methods Sections cardiac...
Aminoacyl-tRNA synthetases catalyze the formation of aminoacyl-tRNA in a two-step reaction starting with amino acid activation followed by aminoacyl group transfer to tRNA. To clear mistakes that occasionally occur, some these enzymes carry out editing activities, acting on misactivated (pretransfer editing) or after tRNA (post-transfer editing). The post-transfer pathway leucyl-tRNA synthetase has been extensively studied structural and biochemical approaches. Here, we report finding...
To prevent potential errors in protein synthesis, some aminoacyl-transfer RNA (tRNA) synthetases have evolved editing mechanisms to hydrolyze misactivated amino acids (pre-transfer editing) or misacylated tRNAs (post-transfer editing). Class Ia leucyl-tRNA synthetase (LeuRS) may misactivate various natural and non-protein then mischarge tRNA Leu . It is known that the fidelity of prokaryotic LeuRS depends on multiple pathways clear incorrect intermediates products every step aminoacylation...