A5100375329- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS drug development and treatment
- Peptidase Inhibition and Analysis
- HIV Research and Treatment
- Acute Myeloid Leukemia Research
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Click Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Protease and Inhibitor Mechanisms
- Cancer Research and Treatments
- Colorectal Cancer Screening and Detection
- Pneumocystis jirovecii pneumonia detection and treatment
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
Nanjing Medical University
2015-2025
Nanjing University
2025
China Medical University
2022-2025
Shandong University
2014-2024
Shanghai Jiao Tong University
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Shanghai Sixth People's Hospital
2009-2024
Shandong Provincial Hospital
2017-2024
Xijing Hospital
2010-2024
Xinxiang Medical University
2017-2024
Background Immune checkpoint inhibitors monotherapy has been studied in patients with advanced biliary tract cancer (BTC). The aim of this study was to assess the efficacy and safety camrelizumab, plus gemcitabine oxaliplatin (GEMOX) as first-line treatment BTC explored potential biomarkers associated response. Methods In single-arm, open-label, phase II study, we enrolled stage IV patients. Participants received camrelizumab (3 mg/kg) (800 mg/m 2 ) (85 ). Primary endpoints were 6-month...
Abstract Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these numerically scarce functionally exhausted the tumor microenvironment (TME), leading to inefficacious immunotherapies most patients with cancer. By contrast, emerging evidence suggested that tumor-irrelevant bystander (T BYS ) abundant preserve functional memory properties TME. To leverage TME eliminate cells, we engineered oncolytic virus (OV) encoding epitopes...
Abstract IL-17, a major inflammatory cytokine plays critical role in the pathogenesis of many autoimmune diseases. In this study, we report new function RNA-binding protein HuR IL-17–induced Act1-mediated chemokine mRNA stabilization. deficiency markedly reduced expression due to increased decay. polyubiquitination was required for binding CXCL1 mRNA, leading Although IL-17 induced coshift Act1 and polysomal fractions sucrose gradient, ratio translation-active/translation-inactive mRNAs....
Aerobic glycolysis is a phenomenon by which malignant cells preferentially metabolize glucose through the glycolytic pathway, rather than oxidative phosphorylation to proliferate efficiently. The present study aimed investigate expression and functional implications of long non-coding (lnc)RNA Ftx in aerobic tumorigenesis hepatocellular carcinoma (HCC). It was identified that lncRNA upregulated human HCC tissues cell lines and, notably, associated with aggressive clinicopathological...
Abstract Inflammatory responses play a central role in coordinating biomaterial‐mediated tissue regeneration. However, precise modulation of dynamic variations microenvironmental inflammation post‐implantation remains challenging. In this study, the traditional β‐tricalcium phosphate‐based scaffold is remodeled via ultrathin MXene‐Ti 3 C 2 decoration and Zn 2+ /Sr ion‐substitution, endowing with excellent reactive oxygen species‐scavenging ability, near‐infrared responsivity, enhanced...
Significance Myelodysplastic syndrome (MDS) represents a common hematopoietic disease, often in elderly patients, with heterogeneous clinical phenotypes and complex disease mechanisms. Here, we report on characteristic genome lesions, clonal architecture, distinct tumor clone expansion patterns group of patients refractory anemia excess blasts, the MDS subtype highest propensity to acute myeloid leukemia. An integrative gene mutation analysis 196 different subtypes allowed regulatory network...
Background and Aims Hepatocellular carcinoma (HCC) is linked to immunosuppression. Relieving immunosuppression has been an attractive strategy improve the efficacy of cancer immunotherapy. Peptidoglycan recognition protein 2 (PGLYRP2) a pattern receptor which specifically expressed in liver implicated regulation innate immunity immunosurveillance. However, role hepatic PGLYRP2 modulating immune responses against HCC remains be investigated. Approach Results In this study, we investigated...
Objective: To investigated the association between sarcopenia and prognosis adverse events of hepatocellular carcinoma (HCC) patients undergoing interventional therapy combined with immunotherapy targeted therapy. Methods: Between January 2019 December 2022, unresectable HCC who received were included in this study. Total skeletal muscle area at L3 level was normalized for height m 2 as index (SMI). All divided into low high SMI group according to median SMI. Results: Ninety-six consecutive...
<title>Abstract</title> <bold>Objective:</bold> To identify adverse drug event (ADE) signals associated with baloxavir marboxil in patients aged ≥65 years, providing a reference for safe and rational clinical use. <bold>Methods:</bold> ADE reports listing as the primary suspected were collected from U.S. FDA Adverse Event Reporting System (FAERS) spanning 83 quarters, first quarter of 2004 to third 2024. After removing duplicate reports, standardizing data, excluding unspecified ages, data...
Epithelial ovarian cancer, the most prevalent form of is a health concern worldwide. Phosphoserine aminotransferase 1 (PSAT1), as rate‑limiting enzyme in serine synthesis, key conversion 3‑phosphoglycerate to serine. The present study explored role PSAT1 expression epithelial tumors. Gene Expression Profiling Interactive Analysis was used for gene and survival analyses. effects overexpression knockdown on invasion, migration, proliferation cell cycle progression cancer lines were...
Abstract Bone marrow mesenchymal stem cells (BMMSCs) facilitate the growth of multiple myeloma (MM) cells, but underlying mechanisms remain unclear. This study demonstrates that senescence MM-MSCs significantly increased, as evidenced by a decrease in proliferation and increase number positive for senescence-associated β-galactosidase activity. Senescent displayed decreased differentiation potential increased tumor-supporting capacity. Dicer1 knockdown MSCs healthy controls promoted cellular...
Objective: To investigate the prognostic value of tumor size in colorectal cancer (CRC) patients with different primary locations. Patients and methods:We retrospectively recruited 3971 stage I-III CRC curative resection.The propensity score matching technique was conducted to reduce selection bias, producing a matched cohort 1347 pairs based on (≤4 cm >4 groups).Kaplan-Meier survival analyses univariate multivariate were used compare overall (OS), cancer-specific (CSS) disease-free (DFS)...
Accumulating evidence has elucidated the biological function of lncRNAs in various tumors. FGD5 antisense RNA 1 (FGD5-AS1) is identified as a significant tumor regulator malignancies. Up to now, detailed FGD5-AS1 cervical cancer and its underlying molecular mechanisms remain uninvestigated. Bone marrow stromal cell antigen 2 (BST2) can play critical roles immune response, BST2 was explored currently. The level detected by qRT-PCR cells. expression significantly upregulated Then, decrease...
Background Diabetic nephropathy (DN) is a serious complication among patients with diabetes. Elucidating its pathogenesis crucial for identifying novel biomarkers and therapeutic targets DN. Methods DN tissues were harvested examining MALAT1, LIN28A Nox4. Human kidney-2 (HK-2) cells treated high glucose (HG) establishing cell model of Cell viability was examined by MTT assay. HG-induced apoptosis secretion TNF-α IL-6 analyzed TUNEL ELISA assays, respectively. RIP RNA pull-down assays applied...
Recent studies suggest that the interaction between presbycusis and cognitive impairment may be partially explained by cognitive-ear link. However, underlying neurophysiological mechanisms remain largely unknown. In this study, we combined magnetic resonance spectroscopy (MRS) resting-state functional imaging (fMRI) to investigate auditory gamma-aminobutyric acid (GABA) glutamate (Glu) levels, intra- inter-network connectivity, their relationships with function in 51 patients well-matched...
Purpose: It remains unclear whether the MTHFR C677T, A1298C and ABCB1 C3435T genetic variants are associated with methotrexate (MTX) elimination delay high-dose MTX (HD-MTX) toxicities in treatment of pediatric acute lymphoblastic leukemia (ALL). The aim our study was to analyze potential predictive role relationship between these during HD-MTX therapy ALL patients. Patients Methods: We conducted a retrospective on patients receiving available genotype 44-h plasma levels. Logistic regression...