A5107999855- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Plant Virus Research Studies
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Anaerobic Digestion and Biogas Production
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Long-Term Effects of COVID-19
- Animal Disease Management and Epidemiology
- Biofuel production and bioconversion
- Research on scale insects
- Wastewater Treatment and Nitrogen Removal
- Bacteriophages and microbial interactions
- Hymenoptera taxonomy and phylogeny
- interferon and immune responses
- Insect-Plant Interactions and Control
- Plant-based Medicinal Research
- Fossil Insects in Amber
- Computational Drug Discovery Methods
- Plant and Fungal Interactions Research
China Agricultural University
2016-2025
Northwestern Polytechnical University
2010-2024
Zhejiang University
2024
Institute of Biophysics
2024
Everbright International (China)
2024
Krirk University
2024
Hodges University
2024
Rensselaer Polytechnic Institute
2023
University of Macau
2021
Tiande (China)
2020
In this study, we determined and genetically characterized three fowl adenoviruses isolated from chickens with inclusion body hepatitis (IBH) hydropericardium syndrome (HPS) in China assessed their pathogenicity. The full genome of HBQ12, BJH13 JSJ13 was found to be 44,081, 43,966 43,756 nucleotides long, respectively. Sequence alignment phylogenetic analysis revealed that strain HBQ12 were clustered together belonging D species serotyped as FAdV-11, whereas classified into C FAdV-4. To our...
λ-Carrageenan (Carr), a seaweed polysaccharide, is used as proinflammatory agent in research. Betulinic acid (BA), naturally occurring pentacyclic triterpenoid, exerts immunomodulatory, antioxidant, anti-inflammatory, antitumor, anti-malarial and anti-HIV effects. The aim of this study was to investigate whether BA anti-inflammatory effect against Carr-induced paw edema mice, how could mediate the expression inflammation-associated MAPK-COX-2-PGE2 signal pathway. pretreatment significantly...
Abstract Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these numerically scarce functionally exhausted the tumor microenvironment (TME), leading to inefficacious immunotherapies most patients with cancer. By contrast, emerging evidence suggested that tumor-irrelevant bystander (T BYS ) abundant preserve functional memory properties TME. To leverage TME eliminate cells, we engineered oncolytic virus (OV) encoding epitopes...
Newcastle disease virus (NDV) is an avian pathogen with unsegmented negative-strand RNA genome that belongs to the Paramyxoviridae family. While primarily pathogenic in birds, NDV presents no threat human health, rendering it a safe candidate for various biomedical applications. Extensive research has highlighted potential of as vector vaccine development and gene therapy, owing its transcriptional modularity, low recombination rate, lack DNA phase during replication. Furthermore, exhibits...
ABSTRACT Coronaviruses are characterized by their progeny assembly and budding in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). Our previous studies demonstrated that truncation of 9 amino acids cytoplasmic tail (CT) infectious bronchitis virus (IBV) spike (S) protein impairs its localization to ERGIC, resulting increased expression at plasma membrane. However, precise mechanism underlying this phenomenon remained elusive. In study, we provide evidence IBV S could utilize...
Avian infectious bronchitis is a highly contagious disease caused by virus (IBV) that affects poultry production worldwide. The absence of vaccine cross-protection and the frequent emergence new variant strains complicate control IBV. Here we designed study to measure evolution dynamics IBV in China. One hundered seven complete sequences 1022 S1-region Chinese IBVs isolated between 1994 2014 were analysed using MEGA 5.0 software Bayesian analysis sampling trees (BEAST) method, selection...
Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2′ site) upstream of the fusion peptide in spike protein, which plays roles virion adsorption and fusion. Mutation S2′ QX genotype (QX-type) infectious bronchitis virus (IBV) protein (S) a recombinant background results higher pathogenicity, pronounced neural symptoms neurotropism when compared with conditions wild-type IBV (WT-IBV) infected chickens. In this study, we present evidence suggesting that mutant...
The adaptive immunity that protects patients from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), is not well characterized. In particular, the asymptomatic have been found to induce weak and transient SARS-CoV-2 antibody responses, but underlying mechanisms remain unknown; meanwhile, protective guide recovery of these elusive. Here, we characterized SARS-CoV-2-specific B-cell T-cell responses in 10 64 with other severity (mild, n = 10,...
The first complete mitochondrial genome of the lacewing family Osmylidae (Thyridosmylus langii (McLachlan, 1870)) (Neuroptera) was sequenced in this study. is a circular molecule 16,221 bp containing typical 37 genes but arranged same order as that putative ancestor hexapod and lacks translocation trnC shared by all previously neuropteran mtDNAs. This reveals does not represent an organizational synapomorphy mitochondrion for entire Neuroptera clade. Comparative analysis tRNA relatively slow...
Cellular immune responses play a key role in the control of viral infection. The nucleocapsid (N) protein infectious bronchitis virus (IBV) is major immunogenic that can induce protective immunity. To screen for potential T-cell epitopes on IBV N protein, 40 overlapping peptides covering entirety were designed and synthesized. Four epitope identified by gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISpot), intracellular cytokine staining, carboxyfluorescein succinimidyl ester...
Inactivated and live attenuated vaccines are the mainstays of preventing viral poultry diseases. However, development recombinant DNA technology in recent years has enabled generation virus vector vaccines, which have advantages multiple diseases simultaneously simplifying vaccination schedule. More importantly, some can induce a protective immune response presence maternal antibodies offer long-term protection. These compensate for shortcomings traditional vaccines. This review describes...
To evaluate the contribution of length diversity in hemagglutinin-neuraminidase (HN) protein to pathogenicity, replication and biological characteristics Newcastle disease virus (NDV), we used reverse genetics generate a series recombinant NDVs containing truncated or extended HN proteins based on an infectious clone genotype VII NDV (SG10 strain). The mean death times intracerebral pathogenicity indices these viruses showed that different mutations did not alter virulence NDV. In vitro...
Infectious bronchitis is a severe disease caused by infectious virus (IBV) that affects fowl flocks worldwide. The understanding of the mechanisms involved in IBV evolution and variation would provide important theoretical basis for prevention control future.IBV strain GD was isolated from southern China 2013 complete genome sequencing phylogenetic analysis were performed.The approximately 27,680 nt comprised six genes, with insertions mutations most structural genes. S1 gene showed highest...
To explore the critical genes associated with infectious bronchitis virus (IBV) virulence, we compared genome sequences of virulent YN strain and its attenuated aYN. Accumulation mutations in S gene accessory 5a were observed, suggesting a potential role loss viral pathogenicity. Two recombinant IBVs (rIBVs) replacement or corresponding regions from aYN rescued to verify this speculation. Embryo mortality time/rate showed that rYN-S-aYN rYN-5a-aYN had an phenotype ovo. Replication assay ovo...
Coronaviruses can emerge from animal reservoirs into naive host species to cause pandemic respiratory and gastrointestinal diseases with significant mortality in humans domestic animals. Infectious bronchitis virus (IBV), a γ-coronavirus, infects respiratory, renal, reproductive systems, causing millions of dollars lost revenue worldwide annually.
Abstract The first phylogeny of the lacewing family O smylidae is presented here based on a total evidence analysis DNA sequences for multiple gene loci and morphology representatives almost all extant genera. Our shows basal dichotomy in family, with subfamilies P rotosmylinae, S pilosmylinae G umillinae comprising one lineage, other lineage including smylinae, orisminae, E idoporisminae, K empyninae tenosmylinae. status aryphosmylus rüger L ysmus N avás as members rotosmylinae affirmed...