A5070564367- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and Biological Activities
- Drug-Induced Hepatotoxicity and Protection
- Gastrointestinal disorders and treatments
- Mycotoxins in Agriculture and Food
- IgG4-Related and Inflammatory Diseases
- Cancer and Skin Lesions
- Ocular Surface and Contact Lens
- Alcohol Consumption and Health Effects
- Chemotherapy-induced organ toxicity mitigation
- Plant Toxicity and Pharmacological Properties
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxin Mechanisms and Immunotoxins
- Neuroendocrine Tumor Research Advances
- Estrogen and related hormone effects
- Glaucoma and retinal disorders
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Nasolacrimal Duct Obstruction Treatments
- Acute Lymphoblastic Leukemia research
- Edible Oils Quality and Analysis
- Phytochemicals and Antioxidant Activities
- Retinal Diseases and Treatments
- Acute Myeloid Leukemia Research
The First People's Hospital of Changzhou
2025
Anhui Provincial Children's Hospital
2025
Children's Hospital of Fudan University
2025
Hunan Agricultural University
2015-2024
Gansu University of Traditional Chinese Medicine
2016-2024
Zunyi Medical University
2024
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2024
Anhui Provincial Center for Disease Control and Prevention
2023
Fudan University
2023
λ-Carrageenan (Carr), a seaweed polysaccharide, is used as proinflammatory agent in research. Betulinic acid (BA), naturally occurring pentacyclic triterpenoid, exerts immunomodulatory, antioxidant, anti-inflammatory, antitumor, anti-malarial and anti-HIV effects. The aim of this study was to investigate whether BA anti-inflammatory effect against Carr-induced paw edema mice, how could mediate the expression inflammation-associated MAPK-COX-2-PGE2 signal pathway. pretreatment significantly...
T-2 toxin, which is mainly produced by specific strains of Fusarium in nature, can induce immunotoxicity and oxidative stress, resulting immune organ dysfunction apoptosis. Betulinic acid (BA), a pentacyclic triterpenoids from nature plants, has been demonstrated to possess immunomodulating antioxidative bioactivities. The purpose the study was explore effect BA on toxin-challenged spleen damage further elucidate underlying mechanism. We found that not only ameliorated contents serum total...
Zearalenone (ZEA) is a nonsteroidal estrogenic mycotoxin, which mainly contaminates grains and has estrogen-like effects on the reproductive system. Betulinic acid (BA), natural lupane-type pentacyclic triterpene, anti-oxidative anti-inflammatory properties. This study aimed to investigate whether BA alleviates ZEA-induced testicular damage explore possible mechanism. Here, ameliorated by mitigating disordered arrangement of seminiferous tubules, exfoliation lumen cells, increase cell...
T-2 toxin, the most toxic of trichothecenes, is widely found in grains and feeds, its intake poses serious risks to health humans animals. An important cytotoxicity mechanism toxin production excess free radicals, which turn leads oxidative stress. Betulinic acid (BA) has many biological activities, including antioxidant activity, a plant-derived pentacyclic triterpenoid. The protective effects mechanisms BA blocking stress caused by acute exposure thymus mice was studied. pretreatment...
Objective: To investigate the role of ferroptosis in renal cell injury induced by diquat (DQ) . Methods: From January to October 2022, human tubular epithelial (HK-2) cells were treated with DQ for 48 h, and different doses inhibitors [deferoxamine (DFO), Fer-1] added, harvested 24 h later. The experiment was divided into 6 groups (n=6) : control group, group (60 μmol/L), 20 μmol/L DFO (DFO-H) 10 (DFO-L) 5 Fer-1 (Fer-1-H) 0.5 (Fer-1-L) group. December 2022 June 2023, male C57bl/6 mice...
γ-Oryzanol, a mixture of ferulic acid esters plant sterols and triterpene alcohols existed in rice bran oil, can ameliorate lipid metabolism enhance antioxidant activity. In this study, we used hydrogen peroxide (H2O2)-induced injury human hepatic L02 cells to investigate the mechanisms involved hepatoprotective activity γ-oryzanol. The injuries produced by H2O2 include increased levels malondialdehyde (MDA) intracellular reactive oxygen species (ROS), decreased activities superoxide...
Abstract Objectives Patients with IgG4-related disease (IgG4-RD) typically respond well to initial glucocorticoid therapy, but always relapse tapered or maintenance dosage of steroid. We aimed identify the risk factors for IgG4-RD and explore impact active intervention on serologically unstable condition. Methods performed a retrospective study 277 patients at Peking University People’s Hospital from February 2012 through 2019. They were all followed >4 months. The primary outcome was...
T-2 toxin, a trichothecene mycotoxin produced by Fusarium, is widely distributed in crops and animal feed frequently induces intestinal damage. Betulinic acid (BA), plant-derived pentacyclic lupane-type triterpene, possesses potential immunomodulatory, antioxidant anti-inflammatory biological properties. The current study aimed to explore the protective effect molecular mechanisms of BA on mucosal impairment provoked acute exposure toxin. Mice were intragastrically administered (0.25, 0.5,...
Betulinic acid (BA), a pentacyclic triterpenoid, has been associated with several biological effects, such as antioxidant, anti-inflammatory and antiviral activities. Previous studies have demonstrated that BA the ability to alleviate intestinal mucosal damage, however, potential mechanism effect not reported. This study aimed investigate possible protective of against cyclophosphamide (CYP)-induced damage. Here, we found pretreatment prevented barrier dysfuction from CYP-challenged mice by...
Retroperitoneal fibrosis (RPF) is an uncommon condition characterized by inflammation and in the retroperitoneal space. More than two-thirds of RPF are idiopathic, with remaining stemed from a variety secondary causes. It was suggested that IgG4-related form RPF. We undertook this study to compare detailed demographic, clinical laboratory characteristics IRPF large Chinese cohort. retrospectively reviewed medical records 132 patients diagnosed at Peking University People’s Hospital between...
Gamma-oryzanol (Orz), a mixture of the ferulic acid ester triterpene alcohols and phytosterols, was found abundantly in rice bran oil which could be available served as an antioxidant. The present study to explore potential protective effects Orz on oxidative stress cell apoptosis human hepatic cells (L02 cells) induced by hydrogen peroxide (H2 O2 ). Flow cytometry detection Hoechst 33258 staining showed that significantly restored cycle ameliorated H2 -challenged L02 cells. pretreatment...
Betulinic acid (BA), an occurring pentacyclic triterpenoid, has various biological activities, such as anti-inflammation and antioxidation. Previous studies found that BA attenuated cyclophosphamide (CYP)-induced intestinal mucosal damage by inhibiting barrier dysfunctions cell apoptosis. However, the effects regulation mechanisms of on CYP-induced renal not been reported in literature. Here, we pretreatment alleviated elevation serum urea level inhibited increase neutrophil...
Reactive oxygen species (ROS)-mediated retinal pigment epithelium (RPE) cell apoptosis is attributed to age-related macular degeneration (AMD) pathogenesis. FLZ, a novel synthetic squamosamide derivative from Chinese herb, Annona glabra, has displayed significant cyto-protective activity. In the current study, we explored pro-survival effect of FLZ in oxidative stressed-RPE cells and studied underlying signaling mechanisms. Our results showed that attenuated hydrogen peroxide (H2O2)-induced...
IgG4-related disease (IgG4-RD) is recently recognized as a fibro-inflammatory condition featured by tumefactive lesions in multiple organs, and the retroperitoneum one of common involved sites. We undertook this study to compare detailed demographic, clinical laboratory characteristics IgG4-RD patients with lesion (IgG4-RD RPF+) free RPF-) large cohort.We carried out retrospective review medical records 407 cases diagnosed at Peking University People's Hospital between March 2009 May...