A5032937137- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Endometriosis Research and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Gestational Trophoblastic Disease Studies
- IgG4-Related and Inflammatory Diseases
- Mathematical Biology Tumor Growth
- Uterine Myomas and Treatments
- Bone Tumor Diagnosis and Treatments
- Cancer-related molecular mechanisms research
- Gastrointestinal disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Chronic Lymphocytic Leukemia Research
- Metastasis and carcinoma case studies
- Cardiac tumors and thrombi
- Cancer Diagnosis and Treatment
Peking University People's Hospital
2016-2025
Peking University
2016-2025
China Earthquake Administration
2024
China Law Society
2022
Jiangyin People's Hospital
2021
Xuzhou Medical College
2021
Hunan University
2011-2015
The University of Texas MD Anderson Cancer Center
2014
University of Hong Kong
1998-2009
Renmin University of China
2008
Background Results of our previous study showed high objective response but short-term activity apatinib in advanced osteosarcoma. We aimed to investigate the combination with camrelizumab patients inoperable high-grade osteosarcoma progressing after chemotherapy. Methods This open-label, phase 2 trial was conducted at Peking University People’s Hospital. enrolled progressed Patients received 500 mg orally once daily plus 200 by intravenous infusion every weeks until disease progression or...
The aim of this study is to delineate the molecular classification features within Chinese endometrial cancer (EC) patients and evaluate concurrence between two widely employed methods for diagnosing EC subtypes. This retrospective observational cohort encompassed 479 cases analysis. Utilizing next-generation sequencing (NGS) panels targeting POLE, TP53, microsatellite instability (MSI) status, four subtypes [POLE ultramutated (POLE mut), MMR-deficient (MMRd), p53 abnormal (p53abn), no...
Two anti-progesterone receptor (PgR) antibodies, a new one specific to PgRB, the other PgR subtypes A + B, have been used examine cellular location of and B in normal endometrium throughout menstrual cycle early human decidua by standard immunohistochemical techniques. PgR(A+B) is detected antibody recognizing both isoforms receptor. PgRB isoform. Since it not possible raise subtype A, all analysis PgRA subtractive inference. Thus we refer as responsible for positive immunoreactivity when...
To search for potential protein markers of colorectal cancer (CRC), the changes in expression levels between microdissected tumor cells and normal mucosa epithelia were analyzed by an acetylation stable isotopic labeling method coupled with linear quadrupole ion trap fourier transform mass spectrometry (LTQ-FTMS). In total, 137 proteins up-regulated or down-regulated significantly at least two-fold. Based on gene ontology analysis, largest part differential unknown both subcellular...
The aim of the study was to evaluate oncological outcomes complete mesocolic excision (CME) in colon cancer patients.CME is considered a standard procedure for patients. However, previous evidence regarding effect CME on prognosis has fundamental limitations that prevent it from being fully accepted.Patients who underwent radical resection were enrolled between November 2012 and March 2016. According principles CME, patients stratified into 2 groups based intraoperative surgical fields...
Background Lung adenocarcinomas (LUADs) that display radiologically as subsolid nodules (SSNs) exhibit more indolent biological behaviour than solid LUADs. SSNs, commonly encompassing pre-invasive and invasive yet early-stage adenocarcinomas, can be categorised pure ground-glass part-solid nodules. The genomic characteristics of SSNs remain poorly understood. Methods We subjected 154 SSN samples from 120 treatment-naïve Chinese patients to whole-exome sequencing. Clinical parameters...
Patient-derived tumor-like cell clusters may be able to prospectively guide personalized therapeutic selection.
High-grade serous cancer (HGSC) is the most common subtype of ovarian cancer. HGSC highly aggressive with poor patient outcomes, and a deeper understanding tumorigenesis could help guide future treatment development. To systematically characterize underlying pathologic mechanisms intratumoral heterogeneity in human HGSC, we used an optimized single-cell multiomics sequencing technology to simultaneously analyze somatic copy-number alterations (SCNA), DNA methylation, chromatin accessibility,...
Abstract Digital PCR (dPCR) holds immense potential for precisely detecting nucleic acid markers essential personalized medicine. However, its broader application is hindered by high consumable costs, complex procedures, and restricted multiplexing capabilities. To address these challenges, an all‐in‐one dPCR system introduced that eliminates the need microfabricated chips, offering fully automated operations enhanced Using this innovative oscillation‐induced droplet generation technique,...
Calcium and calcium channels are closely related to the estrogen-induced nongenomic effect of endometrial carcinoma, but specific role is unknown. This study aimed explore expression biologic l-type channel in carcinoma cells clarify molecular mechanism relationship between L-type estrogen. The immunohistochemical results showed that Ca2+ subunit α 1D (Cav1.3) was high atypical hyperplasia (1.90 ± 0.35) tissues (2.05 0.82) weak (0.80 0.15) benign (P < 0.05). Treatment with 17b-estradiol...
IgG4-related disease (IgG4-RD) has recently been recognized as a fibro-inflammatory condition featuring tumefactive lesions in multiple organs, and the salivary gland is one of most commonly involved sites. We undertook this study to compare detailed demographic, clinical laboratory characteristics IgG4-RD patients with (IgG4-RD SG+) salivary-gland-free SG-) large cohort.We carried out retrospective review medical records 428 cases diagnosed at Peking University People's Hospital between...
Background Although traditional intraoperative assessments (ie, frozen sections) may lower reoperation rates in patients with breast cancer, time/tissue limitations and accuracy concerns have discouraged their routine clinical use. Full‐field optical coherence tomography (FFOCT) dynamic cell imaging (DCI) are novel techniques offering rapid histologic approximations that unfettered by requisite handling steps. This study was conducted to determine the feasibility diagnostic utility of FFOCT...
Objective: To investigate the clinicopathological characteristics and molecular features of synchronous endometrial ovarian endometrioid carcinoma (SEO-EC). Methods: A total 28 patients diagnosed with SEO-EC at Peking University Third Hospital, Hunan Cancer Hospital People's between September 2016 July 2023 were included retrospectively. Next-generation sequencing (NGS) was performed to assess clonal relatedness paired tumors. Extra-uterine-ovarian disease specimens in four further tested...
Due to the prevalence of low-dose computed tomography (LDCT) screening, detection rate lung cancer presenting as multiple ground-glass opacities (GGOs) is increasing. In statements from the Fleischner Society and International Association for Study Lung Cancer (IASLC) Staging Prognostic Factors Committee, GGOs are considered primary cancers at early stage tumorigenesis.1 2 Accumulating evidence supports notion that metastasis in human can occur an disease progression. Whether may represent...
Endocervical gastric-type adenocarcinoma (GAS) is a rare non-human papillomavirus-associated (NHPVA) with morphologic and immunohistochemical features of gastric differentiation. This study aimed to evaluate cytologic clinicopathological features, differential diagnosis endocervical GAS. A total 23 patients diagnosed GAS/minimal deviation (MDA) at Peking University People's Hospital between 2009 2018 were included. Clinical characteristics, cytologic/histopathologic findings, results...
Abstract Objectives Patients with IgG4-related disease (IgG4-RD) typically respond well to initial glucocorticoid therapy, but always relapse tapered or maintenance dosage of steroid. We aimed identify the risk factors for IgG4-RD and explore impact active intervention on serologically unstable condition. Methods performed a retrospective study 277 patients at Peking University People’s Hospital from February 2012 through 2019. They were all followed &gt;4 months. The primary outcome was...
Previous mutational analysis for BRCA gene mutations in sporadic ovarian cancer occurring Chinese patients Hong Kong identified six germline BRCA1 and one BRCA2 mutation, of which were novel (Khoo et al., 2000). Knowledge the population is relatively scant. In this study, we focussed on whether any these could be recurrent our population, making use archival paraffin embedded tissue. A consecutive series 214 cases, half Southern origin from whilst other Northern Beijing used study. We...
MRI for Restaging Locally Advanced Rectal Cancer: Detailed Analysis of Discrepancies With the Pathologic Reference StandardXiaoxuan Jia1, Yinli Zhang2, Yi Wang1, Caizhen Feng1, Danhua Shen2, Yingjiang Ye3 and Nan Hong1Audio Available | Share
Retroperitoneal fibrosis (RPF) is an uncommon condition characterized by inflammation and in the retroperitoneal space. More than two-thirds of RPF are idiopathic, with remaining stemed from a variety secondary causes. It was suggested that IgG4-related form RPF. We undertook this study to compare detailed demographic, clinical laboratory characteristics IRPF large Chinese cohort. retrospectively reviewed medical records 132 patients diagnosed at Peking University People’s Hospital between...