A5100696386- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Mathematical Biology Tumor Growth
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Berberine and alkaloids research
- Hepatocellular Carcinoma Treatment and Prognosis
- Glycosylation and Glycoproteins Research
- DNA Repair Mechanisms
- Evolutionary Game Theory and Cooperation
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- Traditional Chinese Medicine Studies
- Evolution and Genetic Dynamics
Peking University
2015-2024
Peking University People's Hospital
2015-2024
China General Nuclear Power Corporation (China)
2024
Guangzhou University of Chinese Medicine
2018-2023
Gynecologic Oncology Group
2023
Beijing Institute of Technology
2021
Nanjing Medical University
2021
Jiangsu Province Hospital
2021
Beijing University of Posts and Telecommunications
2012-2019
North China Electric Power University
2019
Ovarian endometriosis is characterized by the growth of endometrial tissue within ovary, causing infertility and chronic pain. However, its pathophysiology remains unclear. Utilizing high-precision single-cell RNA sequencing, we profile normal, eutopic, ectopic endometrium from 34 individuals across proliferative secretory phases. We observe an increased proportion ciliated cells in both eutopic endometrium, a diminished expression estrogen sulfotransferase, which likely confers apoptosis...
The level of drug metabolism and transport is correlated with the sensitivity cancer cells towards platinum-based chemotherapy. We hypothesize that genetic polymorphisms in metabolising enzymes gene GSTP1 (glutathione S-transferase P1), MRP2 (multidrug resistance-associated protein 2) (ABCC2), which result inter-individual differences disposition, may predict clinical response to platinum agents advanced non-small cell lung (NSCLC) patients.Totally 113 patients NSCLC were routinely treated...
High-grade serous cancer (HGSC) is the most common subtype of ovarian cancer. HGSC highly aggressive with poor patient outcomes, and a deeper understanding tumorigenesis could help guide future treatment development. To systematically characterize underlying pathologic mechanisms intratumoral heterogeneity in human HGSC, we used an optimized single-cell multiomics sequencing technology to simultaneously analyze somatic copy-number alterations (SCNA), DNA methylation, chromatin accessibility,...
Our previous work revealed the high expression of fibrinogen alpha chain (FGA) in patients with endometriosis (EM) and that it could promote migration invasion endometrial stromal cells. Angiogenesis is key condition for development EM. This study was aimed to elucidate role FGA cells involved angiogenesis EM.Immunohistochemistry used detect microvessel density (MVD) VEGF eutopic endometrium samples from EM non-EM. The conditioned medium (CM) human primary (EuESC) immortalized cell line...
<h3>Background:</h3> Ovarian cancer remains a leading cause of death from gynecological malignancy. Early diagnosis is the most important determinant survival. For more than 25 years, antigen 125 (CA 125) has been criterion standard biomarker for and management women with epithelial ovarian cancer. This study evaluated human epididymis protein 4 (HE4), novel biomarker, both alone in combination CA as diagnostic marker Chinese population. <h3>Methods:</h3> Sera 491 or nonmalignant disorders...
DNA repair capacity is correlated with sensitivity of cancer cells toward platinum-based chemotherapy. The aim this study was to investigate whether single nucleotide polymorphisms (SNPs) in gene ERCC1 (excision cross-complementation group 1) and XPD (ERCC2, excision 2) were associated the tumor response advanced non-small-cell lung (NSCLC) patients received chemotherapy Chinese population.Totally 115 NSCLC routinely treated cisplatin- or carboplatin-based chemotherapy, clinical evaluated...
Transforming growth factor-1 (TGF-β1), vascular endothelial factor (VEGF), and interleukin-10 (IL-10) may be critical cytokines in the microenvironment of a tumor, playing roles immune suppression. This study was conducted to elucidate immunosuppressive functions these epithelial ovarian cancer (EOC).The expression levels TGF-β1, VEGF IL-10 malignant tissue were evaluated by immune- histochemistry compared with corresponding borderline, benign, tumor-free tissues. Moreover, relationships...
Lacking a satisfactory screening test, ovarian cancer is frequently diagnosed at late stage, leading to poor patient outcomes. This study investigated the diagnostic value of circulating tumor cells (CTCs) in peripheral blood from patients with suspected tumors. Sixty-one women having an mass were prospectively enrolled this study. CTCs identified and counted using microfluidic isolation immunofluorescent staining CD45, HE4, epithelial mesenchymal (E&M) markers (epithelial cell adhesion...
Abstract Background: High-grade serous ovarian cancer (HGSOC) is the biggest cause of gynecological cancer-related mortality because its extremely metastatic nature. This study aimed to explore and evaluate characteristics candidate factors associated with metastasis progression HGSOC. Methods: Transcriptomic data HGSOC patients' samples collected from primary tumors matched omental were obtained three independent studies in National Center for Biotechnology Information (NCBI) Gene...
This paper presents a clinical comparison of the target dose, normal tissue complication probability (NTCP), and plan quality between volumetric modulated conformal arc therapy (VMAT) against dynamic (DCAT) techniques to facilitate decision-making in multiple brain metastases (MBM) treatment. A total 11 cases having 33 lesions were recruited at Union Oncology Centre, Hospital, Hong Kong SAR. With CT images available, all plans optimized using both HyperArc (HA) Brainlab Elements Multiple...
Endometriosis (EM) is a mysterious and complicated disease that has been found to be multifactorial. Recent studies demonstrated long noncoding RNAs (lncRNAs) play an important role in the pathogenesis of EM. However, functional biological mechanisms lncRNAs EM remain unknown. Here, we performed microarray analyses compare lncRNA expression profiles four paired ectopic endometrial (EC) tissues eutopic (EU) from patients with ovarian A novel lncRNA, CCDC144NL-AS1, was identified as being...
Abstract Objective This study aimed to identify the clinical characteristics of Chinese patients with ovarian endometrioid carcinoma (EC) and clear cell (CCC) assess impact concurrent endometriosis on this group. Methods The present reviewed medical records who received initial treatment a postoperative pathological diagnosis EC or CCC at our center in China between 1998 2018. Results Of 211 patients, 73 had pure EC, 91 CCC, remaining 47 mixed cancer. proportion remained stable over past 21...
Background: To investigate the efficacy of TACE combined with CQ, an autophagic inhibitor, in a rabbit VX2 liver tumor model.Methods: Tumor size was measured.And growth rate calculated to examine effect treatment.Apoptosis detected by TUNEL assay.Meanwhile, activity immunohistochemistry and Western blotting mechanism underlying.Liver function also examined assess feasibility safety therapy.Results: Tumors control grew more than 4 times bigger after 14 days, while that group alone just showed...
In recent years, immunotherapy has made great progress, and the regulatory role of epigenetics been verified. However, 5-methylcytosine (m5C) in tumor microenvironment (TME) response remains unclear.Based on 11 m5C regulators, we evaluated modification patterns 572 lung adenocarcinoma (LUAD) patients. The score was constructed by principal component analysis (PCA) algorithms order to quantify pattern individual LUAD patients.Two methylation were identified according regulators. two had a...
Tetrandrine is known to exert antitumor effect, however, little about its effect on nasopharyngeal carcinoma cells. In this study, we tested tetrandrine-induced apoptosis and radiosensitivity in cell line CNE investigated the possible mechanisms. Using flow cytometry DNA electrophoresis, found that tetrandrine could induce apoptosis. Further, it was shown level of Bcl-2 mRNA decreased Bax increased after addition by using reverse transcription-polymerase chain reaction. X-ray-induced G2...
Human epididymis protein 4 (HE4) is a promising novel biomarker for the detection of epithelial ovarian cancer (EOC). The role HE4 in EOC tumorigenesis unclear. This study investigated cellular and molecular mechanisms cell proliferation.We generated HE4-overexpressing SKOV3 cells silenced gene expression SKOV3.ip1 cells. We used counting kit 8 assay to evaluate proliferation Western blotting analyze proliferation- apoptosis-associated proteins such as Bax, Bcl-2, caspase 3.Overexpression...
We investigate a Deffuant model on ring by introducing two modifications: the repelling mechanism and circular opinions. The drives opinions of individuals away from each other are defined circle. find that tends to polarize adjacent bring up spatiotemporal pattern in which all take different but opinion difference between neighboring zero limit population size. In with both opinions, dynamics depends bounded confidence convergence rate. interplay may give rise time-dependent dynamics.
DNA repair capacity (DRC) is correlated with sensitivity of cancer cells toward platinum-based chemotherapy. We hypothesize that genetic polymorphisms in gene XPA (xeroderma pigmentosum group A) and XPG G) (ERCC5, excision cross-complementation 5), which result inter-individual differences efficiency, may predict clinical response to platinum agents advanced non-small cell lung (NSCLC) patients. In this study, we find the Aright curved arrow G change A23G polymorphism significantly increased...