A5072567423- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Endometrial and Cervical Cancer Treatments
- Sperm and Testicular Function
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Selenium in Biological Systems
- Circadian rhythm and melatonin
- Bee Products Chemical Analysis
- Uterine Myomas and Treatments
- Complementary and Alternative Medicine Studies
- Acupuncture Treatment Research Studies
- Medicinal Plant Pharmacodynamics Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Estrogen and related hormone effects
- Healthcare and Venom Research
- Drug-Induced Hepatotoxicity and Protection
- Genital Health and Disease
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
Army Medical University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2025
High Point University
2024
Peking University
2011-2024
Peking University People's Hospital
2010-2024
Georgetown University
2018-2024
Northwest Women's and Children's Hospital
2019-2023
First People's Hospital of Chongqing
2020-2023
Xi'an Jiaotong University
2020-2022
Wenzhou Medical University
2021-2022
Female fertility preservation is a major area of interest within the field assisted reproductive technology, in particular ovarian tissue cryopreservation adolescent cancer patients. Melatonin (MLT) has been instrumental our understanding anti-oxidative and anti-apoptotic properties. Whether melatonin can ameliorate cryoinjury generation reactive oxygen species (ROS) cryopreserved tissues (OTs) never investigated. Here, we demonstrated that MLT protects follicular intact, diameter cells...
This study aims to examine the impact of insulin resistance (IR) on risk spontaneous abortion in patients who received infertility treatment.This is a cohort 107 achieved their first pregnancy after treatment tertiary medical center. A homeostasis model assessment IR (HOMA-IR) was carried out. Patient demographic characteristics and outcome were also recorded. Statistical comparison made between with without IR. Logistical regression analysis used assess effect several other factors...
<h3>Background:</h3> Ovarian cancer remains a leading cause of death from gynecological malignancy. Early diagnosis is the most important determinant survival. For more than 25 years, antigen 125 (CA 125) has been criterion standard biomarker for and management women with epithelial ovarian cancer. This study evaluated human epididymis protein 4 (HE4), novel biomarker, both alone in combination CA as diagnostic marker Chinese population. <h3>Methods:</h3> Sera 491 or nonmalignant disorders...
Routine semen parameters have limited clinical diagnostic value for predicting male infertility. The aim of this study was to investigate the association between sperm DNA fragmentation index (DFI) and quality, DFI pregnancy rate in vitro fertilization (IVF) intracytoplasmic injection (ICSI). A total 390 couples undergoing prior receiving conventional IVF (n = 238) or ICSI 152) were evaluated. We found that there no significant differences rate, good embryo high (≥30%) low (<30%) groups...
Objective: To investigate the characteristics and outcomes of low prognosis patients defined by POSEIDON criteria undergoing IVF treatment. Design: Retrospective cohort analysis. Setting: An clinic in a public hospital. Patients: 18,455 fresh aspirated cycles with subsequently frozen embryo transfer from Jan 2014 to 2017 single were included The categorized into 4 groups based on criteria: group 1: age < 35, antral follicle count (AFC) ≥ 5, number oocytes retrieved ≤ 9 previous cycle; 2:...
Abstract STUDY QUESTION Does an increased dosing of FSH improve the live birth rate as compared to standard in expected poor responders who undergo IVF? SUMMARY ANSWER In this trial, women with response allocated did not have a statistically significant increase cumulative births dose. WHAT IS KNOWN ALREADY Poor ovarian reserve leads worse IVF outcomes owing low number and quality oocytes. Clinicians often individualize dose using tests, including antral follicle count (AFC), basal plasma or...
Organ damage caused by electric shock has attracted great attention. Some animal investigations and clinical cases have suggested that can induce liver injury. This study aimed to investigate the potential mechanism of injury induced shock. Healthy male C57BL/6J mice aged 6-8 weeks were romandly divided into two groups: control group group. Mice in shocked on top skull with an baton (20 kV) for 5 sec, while exposed only acoustic light stimulation produced baton. The effect function was...
Fertility-sparing therapy is an alternative conservative treatment for patients with early stage endometrioid cancer or atypical endometrial hyperplasia. In this study, we investigated pregnancy outcomes and pregnancy-associated factors in young receiving hormonal therapy.We retrospectively analyzed 68 who attempted to conceive after fertility-sparing achieving complete remission (CR). They were divided into a group non-pregnancy group. A Cox proportional hazard regression model was applied...
Objective: To investigate the cumulative live birth rates (CLBR) according to body mass index (BMI) in women undergoing first vitro fertilization (IVF). Design: Retrospective cohort analysis. Setting: An IVF clinic a public hospital. Patients: This is retrospective study of 14782 patients fresh cycles with subsequently frozen embryo transfer during Jan 2014-Jan 2017 our clinic. The follow-up continued for CLBR until 2019. Patients BMI 24 kg/m2 were considered be overweight (Obese ≥28 kg/m2)....
Endometrial cancer (EC) is one of the most common gynecologic malignancies. The present study aims to identify a metabolism-related biosignature for EC and explore molecular immune-related mechanisms underlying tumorigenesis EC. Transcriptomics clinical data were retrieved from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Common differentially expressed genes extracted risk signature was identified by using least absolute shrinkage selection operator (LASSO) regression...
We investigated possible biomarkers for endometriosis (EM) using the ClinProt technique and proteomics methods.We enrolled 50 patients with EM, 34 benign ovarian neoplasms 40 healthy volunteers in this study. Serum proteomic spectra were generated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MS) combined weak cationic exchange (WCX) magnetic beads. Possible analyzed a random repeat pattern model-validation method that we designed, ClinProtools software,...
To investigate factors associated with HIV infection and the frequency willingness of male circumcision among men who have sex (MSM) in Chengdu city, China. A cross-sectional survey provided information on participants' demographics, risk behaviors, circumcision, uptake prevention services. Of 570 participants, 13.3% were infected 15.9% syphilis. An estimated 43.0% respondents reported having unprotected receptive anal intercourse, 58.9% ≥2 sexual partners past 6 months. Multivariable...
Carnosol is an ortho-diphenolic diterpene with excellent antioxidant potential. The present study was designed to identify the protective role of carnosol against spinal cord injury (SCI)-induced oxidative stress and inflammation in Wistar rats.In study, status determined through estimating total capacity, oxidant status, lipid peroxide content, protein carbonyl sulfhydryl levels, reactive oxygen species (ROS), (superoxide-dismutase, catalase, glutathione, glutathione peroxidase,...
The protective effect of iridoid glucosides from Boschniakia rossica (BRI) against carbon tetrachloride (CCl4)-induced liver injury was examined. CCl4 at a dose 0.5 ml/kg body weight given intraperitoneally to rats induce damage. were sacrificed 16 h after the injection. challenge caused marked increase in levels serum animotransferases, tumor necrosis factor-α (TNF-α) and hepatic inducible nitric oxide synthase (iNOS) protein, depleted reduced glutathione (GSH), propagated lipid...
Fertility-sparing treatment of atypical endometrial hyperplasia (AEH) and early carcinoma (EC) patients has recently emerged important social health topic. This study is designed to explore the risk factors for time complete remission (CR) fertility-sparing in woman with AEH EC.A retrospective was clinical data from 106 admitted between January 2012 December 2019. Univariate multivariate logistic analysis were used independent CR. These employed receiver operator characteristic (ROC) curve...
As one of main active ingredients salvia miltiorrhizae, which is a traditional Chinese medicine, tanshinone IIA the basis its pharmacological activities. In present study, effect on weakening spastic cerebral palsy (SCP) in neonatal rats was investigated. Radial arm water maze and holding tests were used to measure alterations palsy, inflammation measured using an ELISA kit, western blot analysis analyze protein expression p‑p38 mitogen‑activated kinase (MAPK) vascular endothelial growth...
Fertility-sparing treatment for young women with atypical endometrial hyperplasia (AEH) and early cancer (EC) is a difficult challenge. Insulin resistance (IR) metabolic syndrome (MetS) are two potentially crucial, but currently enigmatic factors in the recurrence of AEH EC patients. In this study we attempt to elucidate these factors.A retrospective was conducted from January 2010 December 2019. Risk complete remission time after (RCR time) were investigated. ROC curves built estimate...
To explore the potential mechanism of cancer patients appearing more vulnerable to SARS-CoV-2 infection and poor COVID-19 outcomes, we conducted an integrative bioinformatics analysis for SARS-CoV-2-required genes host variants related susceptibility severity. BLCA, HNSC, KIRC, KIRP, LGG, PCPG, PRAD, TGCT, THCA carrying rs10774671-A (OAS1) genotype may be likely have outcomes relative those who carry rs10774671-G, because individuals will lower expression OAS1, which serves as a protective...