A5045467479- Neuroendocrine regulation and behavior
- Hypothalamic control of reproductive hormones
- Stress Responses and Cortisol
- Plant Reproductive Biology
- Neuropeptides and Animal Physiology
- Ovarian function and disorders
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Eicosanoids and Hypertension Pharmacology
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Hormonal Regulation and Hypertension
- Menstrual Health and Disorders
- Pharmacological Effects of Natural Compounds
- Renal and related cancers
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Gestational Diabetes Research and Management
- MicroRNA in disease regulation
- melanin and skin pigmentation
- Meat and Animal Product Quality
Brigham and Women's Hospital
2023-2025
Harvard University
2023-2025
King's College London
2018-2024
Lomonosov Moscow State University
2003-2007
Institute of Molecular Genetics
2003-2006
Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting neurons found in the arcuate nucleus, known as KNDy co-expressing neurokinin B, and dynorphin, drive pulsatile release. Furthermore, gonadal steroids regulate dynamics across ovarian cycle by altering neurons' signalling properties. However, precise mechanism of regulation remains mostly unknown. To better understand these mechanisms, we start perturbing system at different stages estrous using...
Abstract Corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of hypothalamus (PVN) are central to stress response. Chemogenetic activation PVN CRH decreases LH pulse frequency but mechanism is unknown. In present study, optogenetic stimulation suppressed estradiol-replaced ovariectomized CRH-cre mice, and this effect was augmented or attenuated by intra-PVN GABAA GABAB receptor antagonism, respectively. signal local GABA neurons, which may provide a possible indirect...
Abstract Context Maternal obesity increases the risk of preterm delivery. Obesity is known to be associated with altered lipid metabolism. Objective To investigate associations between high maternal triglyceride (mTG) levels during early pregnancy and risks delivery stratified by body mass index (BMI). Design Retrospective cohort study. Setting University-based maternity center. Patients 49,612 women singleton who underwent fasting serum screening pregnancy. Main Outcome Measures Risk...
Abstract Kisspeptin neurons in the arcuate nucleus of hypothalamus generate gonadotrophin‐releasing hormone (GnRH) pulses, and act as critical initiators functional gonadotrophin secretion reproductive competency. However, kisspeptin other brain regions, most notably posterodorsal subnucleus medial amygdala (MePD), plays a significant modulatory role over hypothalamic population; our recent studies using optogenetics have shown that low‐frequency light stimulation MePD results increased...
Normal reproductive function and fertility rely on the rhythmic secretion of gonadotropin-releasing hormone (GnRH), which is driven by hypothalamic GnRH pulse generator. A key regulator generator posterodorsal subnucleus medial amygdala (MePD), a brain region that involved in processing external environmental cues, including effect stress. However, neuronal pathways enabling dynamic, stress-triggered modulation remain largely unknown. Here, we employ silico modelling order to explore impact...
Abstract Psychosocial stress disrupts reproduction and interferes with pulsatile LH secretion. The posterodorsal medial amygdala (MePD) is an upstream modulator of the reproductive axis stress. Corticotropin-releasing factor type 2 receptors (CRFR2s) are activated in presence psychosocial together increased expression CRFR2 ligand Urocortin3 (Ucn3) MePD rodents. We investigate whether Ucn3 signalling involved mediating suppressive effect on pulsatility. First, we administered into monitored...
Abstract Psychological stress is linked to infertility by suppressing the hypothalamic GnRH pulse generator. The posterodorsal subnucleus of medial amygdala (MePD) an upstream regulator generator activity and displays increased neuronal activation during psychological stress. MePD primarily a GABAergic nucleus with strong projection reproductive centers; however, their functional significance has not been determined. We hypothesize that signalling mediates stress–induced suppression...
Post-traumatic stress disorder impedes pubertal development and disrupts pulsatile LH secretion in humans rodents. The posterodorsal sub-nucleus of the medial amygdala (MePD) is an upstream modulator hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator, timing, as well emotional processing anxiety. Psychosocial exposure alters neuronal activity within MePD increasing expression Urocortin3 (Ucn3) its receptor corticotropin-releasing factor type-2 (CRFR2) while enhancing...
Abstract Progesterone can block estrogen-induced luteinising hormone (LH) surge secretion and be used clinically to prevent premature LH surges. The blocking effect of progesterone on the is mediated through its receptor in anteroventral periventricular nucleus (AVPV) hypothalamus. However, underlying mechanisms are unclear. preovulatory induced by estrogen preceded a significant reduction hypothalamic dynorphin gamma-aminobutyric acid (GABA) release. To test detailed roles GABA an blockade...
Normal reproductive function and fertility rely on the rhythmic secretion of gonadotropin-releasing hormone (GnRH), which is driven by hypothalamic GnRH pulse generator. A key regulator generator posterodorsal subnucleus medial amygdala (MePD), a brain region involved in processing external environmental cues, including effect stress. However, neuronal pathways enabling dynamic, stress-triggered modulation remain largely unknown. Here, we employ in-silico modelling order to explore impact...
Psychosocial stress negatively impacts reproductive function by inhibiting pulsatile luteinizing hormone (LH) secretion. The posterodorsal medial amygdala (MePD) is responsible in part for processing and modulating the axis. Activation of neurokinin 3 receptor (NK3R) suppresses gonadotropin-releasing (GnRH) pulse generator, under hypoestrogenic conditions, NK3R activity has been documented to play a role anxiety. We investigate whether activation MePD involved mediating inhibitory effect...
The posterodorsal subnucleus of the medial amygdala (MePD) is an upstream modulator hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes. Inhibition MePD urocortin-3 (Ucn3) neurons prevents psychological stress-induced suppression luteinizing hormone (LH) pulsatility while blocking elevations in corticosterone (CORT) secretion female mice. We explore neurotransmission neural circuitry suppressing gonadotropin-releasing (GnRH) pulse generator by Ucn3 we further...
The tumor microenvironment (TME) is crucial in development, metastasis, and response to immunotherapy. DNA methylation can regulate the TME without altering sequence. However, research on methylation-driven clear-cell renal cell carcinoma (ccRCC) still lacking. In this study, integrated RNA-seq data were used explore genes (MDGs). Immune scores calculated using ESTIMATE, which was employed identify TME-related genes. A new signature connected with methylation-regulated univariate,...
Dendritic cells (DCs) serve as key regulators in tumor immunity, with activated DCs potentiating antitumor responses through the secretion of pro-inflammatory cytokines and expression co-stimulatory molecules. Most current studies focus on relationship between DC subgroups clear-cell renal-cell carcinoma (ccRCC), but there is limited research connection ccRCC from perspective immune activation. In this study, genes were identified both bulk single-cell RNA-seq data. A prognostic model...
Optical systems and genetic engineering technologies have made it possible to control neurons unravel neuronal circuit behavior with high temporal spatial resolution. The application of optogenetic strategies understand the physiology kisspeptin circuits has evolved in recent years among neuroendocrine community. Kisspeptin are fundamentally involved controlling mammalian reproduction but also implicated numerous other physiological processes, including not limited feeding, energy...
Abstract Chronic exposure to predator odour stress disrupts LH pulsatility and delays puberty whileactivation of amygdala kisspeptin advances pubertyDeyana Ivanova MS1, Xiao Feng Li MD/PhD1, Caitlin Mcintyre BS1, Kevin O’Byrne PhD1; 1Department Women Children’s Health, Faculty Life Science Medicine, King’sCollege London, UKPost-traumatic (PTSD) is associated with altered pubertal timing odourexposure a classical rodent PTSD model. Kisspeptin neurones in the posterodorsal sub-nucleus medial...
Abstract Post-traumatic stress disorder impedes pubertal development and disrupts pulsatile LH secretion in humans rodents. The posterodorsal sub-nucleus of the medial amygdala (MePD) is an upstream modulator hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator, timing, as well emotional processing anxiety. Psychosocial exposure alters neuronal activity within MePD increasing expression Urocortin3 (Ucn3) its receptor corticotropin-releasing factor type-2 (CRFR2) while enhancing...