A5052539627- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Galectins and Cancer Biology
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- RNA Research and Splicing
- Biochemical and Molecular Research
- TGF-β signaling in diseases
- Microbial Metabolic Engineering and Bioproduction
- Gene Regulatory Network Analysis
- Histone Deacetylase Inhibitors Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Photoreceptor and optogenetics research
- Connective Tissue Growth Factor Research
- Mitochondrial Function and Pathology
- Bone Metabolism and Diseases
- Sirtuins and Resveratrol in Medicine
Chongqing Medical University
2022-2025
Peking University
2024
Dalian Medical University
2022-2024
Second Affiliated Hospital of Chongqing Medical University
2022-2024
University of Illinois Urbana-Champaign
2024
Synthetic microbial communities have emerged as an attractive route for chemical bioprocessing. They are argued to be superior single strains through division of labor (DOL), but the exact mechanism by which DOL confers advantages remains unclear. Here, we utilize a synthetic Saccharomyces cerevisiae consortium along with mathematical modeling achieve tunable mixed sugar fermentation overcome limitations single-strain fermentation. The involves two each specializing in glucose or xylose...
Abstract Sorafenib is one a first‐line therapeutic drugs for advanced hepatocellular carcinoma (HCC). However, only 30% of patients benefit from sorafenib due to drug resistance. We and other groups have revealed that nuclear factor I B (NFIB) regulates liver regeneration carcinogenesis, but its role in resistance poorly known. found NFIB was more upregulated sorafenib‐resistant SMMC‐7721 cells compared parental cells. knockdown not sensitized drug‐resistant also inhibited the proliferation...
Abstract Nuclear factor I B (NFIB) plays an important role in tumors. Our previous study found that NFIB can promote colorectal cancer (CRC) cell proliferation acidic environments. However, its biological functions and the underlying mechanism CRC are incompletely understood. Nicotinamide adenine dinucleotide (NAD+) effectively affects proliferation. Nevertheless, regulatory of NAD+ synthesis remains to be elucidated. Here we show promotes vitro growth vivo, down-regulation reduce level...
In living cells, the bistable switches involving phosphorylation-dephosphorylation (PdP) cycles, operate far from thermodynamic equilibrium and consume hydrolysis free energy to perform ultrasensitive response exhibit strong robustness against noise. Here, we focus on distinct roles of cellular ATP levels ([ATP]) (<a:math xmlns:a="http://www.w3.org/1998/Math/MathML"><a:mrow><a:mi mathvariant="normal">Δ</a:mi><a:mi>μ</a:mi></a:mrow></a:math>) in with different structures reaction network....
Dendritic cells (DCs) serve as key regulators in tumor immunity, with activated DCs potentiating antitumor responses through the secretion of pro-inflammatory cytokines and expression co-stimulatory molecules. Most current studies focus on relationship between DC subgroups clear-cell renal-cell carcinoma (ccRCC), but there is limited research connection ccRCC from perspective immune activation. In this study, genes were identified both bulk single-cell RNA-seq data. A prognostic model...
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Numerous studies have shown that metabolic reprogramming crucial for development HCC. Carbamoyl phosphate synthase 1 (CPS1), a rate-limiting enzyme in urea cycle, an abundant protein normal hepatocytes, however, lacking systemic research It found CPS1 low-expressed HCC tissues and circulating tumor cells, negatively correlated with stage prognosis. Further study reveals double-edged sword. On hand, it inhibits...