A5101872670- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Gastrointestinal disorders and treatments
- Gout, Hyperuricemia, Uric Acid
- Stroke Rehabilitation and Recovery
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MRI in cancer diagnosis
- Acute Ischemic Stroke Management
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- Peptidase Inhibition and Analysis
- Ovarian function and disorders
- Pelvic and Acetabular Injuries
- Lung Cancer Treatments and Mutations
- Reproductive Biology and Fertility
- Osteoarthritis Treatment and Mechanisms
- Thermal Regulation in Medicine
Chongqing Public Health Medical Center
2025
Chongqing Medical University
2025
Second Military Medical University
2025
Changhai Hospital
2025
Fujian Medical University
2024
Second Affiliated Hospital of Zhejiang University
2013-2024
Shenzhen University
2023
Taizhou People's Hospital
2020-2021
Nantong University
2020-2021
Weatherford College
2021
Abstract Background Gemcitabine resistance (GR) is a significant clinical challenge in pancreatic adenocarcinoma (PAAD) treatment. Macrophages the tumor immune-microenvironment are closely related to GR. Uncovering macrophage-induced GR mechanism could help devise novel strategy improve gemcitabine treatment outcomes PAAD. Therefore, preclinical models accurately replicating patient properties essential for cancer research and drug development. Patient-derived organoids (PDOs) represent...
Nanoparticles composed of galactosylated chitosan oligosaccharide (Gal-CSO) and adenosine triphosphate (ATP) were prepared for hepatocellular carcinoma cell-specific uptake, the characteristics Gal-CSO/ATP nanoparticles evaluated. CSO/ATP as a control. The average diameter zeta potential 51.03 ± 3.26 nm 30.50 1.25 mV, respectively, suggesting suitable properties drug delivery system. Subsequently, cytotoxicity examined by methyl tetrazolium (MTT) assay, half maximal inhibitory concentration...
Tumor mutation burden (TMB) is an important determinant and biomarker for response of targeted therapy prognosis in patients with lung cancer. The present study aimed to determine whether radiomics signature could non-invasively predict the TMB status driver mutations resectable early stage adenocarcinoma (LUAD).A total 61pulmonary nodules (PNs) from 51 post-operatively diagnosed LUAD were enrolled analysis. Two datasets divided according two-thirds different commercial Comprehensive Genomic...
Oncogenic KRAS is considered a promising target for anti‐cancer therapy. However, direct pharmacological strategies targeting KRAS‐driven cancers remained unavailable. The prenyl‐binding protein PDEδ, transporter of KRAS, has been identified as potential inhibitor by selectively binding to its pocket, impairing oncogenic signaling pathway. Here, we discovered novel PDEδ (E)‐N′‐((3‐(tert‐butyl)‐2‐hydroxy‐6,7,8,9‐tetrahydrodibenzo[b,dfuran‐1‐yl)methylene)‐2,4‐dihydroxybenzohydrazide(NHTD)...
Abstract Photodynamic therapy (PDT) holds promise in biochemical study and tumor treatment. A novel multifunctional nanosystem CaO 2 /MnO @polydopamine (PDA)‐methylene blue (MB) nanosheet (CMP‐MB) was designed. nanoparticles were encapsulated by MnO nanosheet, then PDA coated on the surface of nanosheets, which could adsorb photosensitizer MB through hydrophobic interaction or π‐π stacking. In this nanosystem, had ability self‐production oxygen, solved problem hypoxia largely. Moreover, it...
The Yihe River is the largest mountain torrent river in Shandong Province, which plays an important role flood control, irrigation and climate regulation. Due to impacts of upstream urban domestic sewage, as well industrial agricultural wastewater, Linyi City section expected have a high risk metal pollution. Sediments are main reservoir potential release source metals (metalloid) systems. Assessment sediments can identify anthropogenic In this study, 25 sediment samples were collected from...
Postoperative airway, digestive tract, and chest wall fistulas are severe complications after lung resection, often associated with high mortality. Here, we reported a case of patient tracheoesophageal fistulas. After precise localization the fistula sinus tract using multimodal imaging techniques, multidisciplinary treatment team was assembled, including specialists in interventional pulmonology, gastroenterology, plastic surgery, anesthesia, pain management, to develop implement stepwise,...
Abstract The aim of this study was to measure the urate volume within tophus and bone erosion using dual-energy computed tomography in patients with tophaceous gout. Furthermore, our aims quantitatively analyze relationship between monosodium (MSU) crystal deposition according anatomic location deposition. Seventy-seven subjects chronic gout were positively identified for presence Only 27 contact included study. volumes associated measured. relationships separately analyzed Twenty-seven all...
Objective: To describe the imaging features of pelvic solitary plasmacytoma and to correlate them with pathologic grade. Materials Methods:A retrospective study was performed on 10 patients a histological diagnosis plasmacytoma.The studies were assessed for bone expansion, cortical destruction, signal intensity/density soft tissue mass enhancement manifestations, which then correlated Results:The revealed 3 different types: multilocular type (n = 5), unilocular 2) complete osteolytic...
Symptoms that are multidimensional and concurrent should be assessed from different dimensions managed together. Few studies have evaluated symptoms in patients with stroke. Most of stroke focused on dysfunctions complications. We hypothesize a heavy symptom burden within 1 year. This study aimed to describe year after recruited 230 the Rehabilitation Department Xuhui District Center Hospital Shanghai Sunshine China March September 2017. The patients' experience were analyzed using self-made...
OBJECTIVE. The purpose of this study is to establish a diagnostic model for differentiating grade 3 (G3) pancreatic neuroendocrine tumors (PNETs) from ductal adenocarcinomas (PDACs) and analyze survival outcomes. MATERIALS AND METHODS. Twenty patients with G3 PNETs 58 PDACs confirmed by surgery or biopsy were retrospectively included. Demographic radiologic information was collected. Univariate analyses binary logistic regression performed identify independent factors model. An ROC curve...
Pancreatic cancer (PC) is a malignant tumor of the digestive system that has bad prognosis. N6-methyladenosine (m6A) involved in wide variety biological activities due to fact it most common form mRNA modification mammals. Numerous research accumulated evidence suggesting malfunction regulation m6A RNA associated with various illnesses, including cancers. However, its implications PC remain poorly characterized. The methylation data, level 3 sequencing and clinical information patients were...