A5100429241- Vascular Malformations and Hemangiomas
- Vascular Tumors and Angiosarcomas
- Tumors and Oncological Cases
- Vascular Malformations Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Parvovirus B19 Infection Studies
- Gallbladder and Bile Duct Disorders
- Tuberous Sclerosis Complex Research
- Sepsis Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Genetic and Kidney Cyst Diseases
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Intestinal Malrotation and Obstruction Disorders
- Liver Disease Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Renal and related cancers
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Musicians’ Health and Performance
- Reconstructive Facial Surgery Techniques
- Teratomas and Epidermoid Cysts
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Tongji University
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Guangdong Medical College
2017-2024
Wuxi People's Hospital
2024
Nanjing Medical University
2024
Capital University
2024
Kaposiform hemangioendothelioma (KHE) is an aggressive disease with high morbidity and mortality. The aim of this study was to retrospectively evaluate the efficacy safety sirolimus for treatment progressive KHE. A multicenter, retrospective cohort conducted in patients KHE treated sirolimus. total 52 were analyzed. Thirty-seven (71%) exhibited Kasabach-Merritt phenomenon (KMP) significantly younger than without KMP [95% confidence interval (CI), 14.39-41.61; p < 0.001]. Patients all alone,...
Propranolol has become the first-line therapy for problematic infantile hemangiomas (IHs) that require systemic therapy. However, different adverse events have been reported during propranolol treatment. The positive efficacy and safety of atenolol raise question whether it could be used as a promising IH.To compare vs in infants (between age 5 20 weeks) with IHs who required therapy.This was prospective, multicenter, randomized, controlled, open-label clinical trial conducted collaboration...
Background Mitochondrial transcription factor A (TFAM) is a that maintains mitochondrial DNA (mtDNA) stabilization and initiates mtDNA replication. However, little known about the immune regulation function TFAM expression in cells tumors. Methods Mouse tumor models were applied to analyze effect of deficiency myeloid cell lineage on progression microenvironment (TME) modification. In vitro, primary mouse bone marrow-derived dendritic (BMDCs) used investigation altered activated pathway. OVA...
Currently, propranolol is the most preferred systemic therapy for problematic infantile hemangiomas (IHs). However, side effects such as bronchial hyperreactivity may be intolerable. The aim of this study was to evaluate frequency, risk factors and management intolerable (ISEs) during therapy. In total, 1260 children were studied. incidence ISEs 2.1% (26 patients). Severe sleep disturbance common reason cessation, accounting 65.4% cases. 23 3 patients received atenolol prednisolone...
Kaposiform lymphangiomatosis (KLA) and kaposiform hemangioendothelioma (KHE) are rare aggressive vascular disorders. The aim of this study was to examine the clinical features prognosis KLA KHE involving thorax. features, imaging pathological findings, treatments outcome were retrospectively reviewed for 6 patients with 7 mean ages at time presentation signs/symptoms 26.7 months 4.1 KHE, respectively. Respiratory symptoms, pericardial pleural effusion, thrombocytopenia coagulopathy common in...
Autophagy disruption leads to neuronal damage in hypoxic-ischemic brain injury. Rab7, a member of the Rab GTPase superfamily, has unique role regulation autophagy. Hypoxic preconditioning (HPC) provides neuroprotection against transient global cerebral ischemia (tGCI). However, underlying mechanisms remain poorly understood. Thus, current study explored potential molecular mechanism neuroprotective effect HPC by investigating how Rab7 mediates autophagosome (AP) maturation after tGCI adult...
Mitophagy, the selective removal of damaged mitochondria through autophagy, is crucial for mitochondrial turnover and quality control. Docosahexaenoic acid (DHA), an essential omega-3 fatty acid, protects in various diseases. This study aimed to investigate neuroprotective role DHA ischaemic stroke models vitro vivo its involvement mitophagy dysfunction. A mouse model was established middle cerebral artery occlusion (MCAO). To simulate vitro, PC12 cells were subjected oxygen-glucose...
Treatment with sirolimus, an inhibitor of the mammalian target rapamycin pathway, has improved prognosis patients kaposiform hemangioendothelioma (KHE). However, efficacy, durability and tolerability long-term sirolimus treatment in KHE have not been well elucidated. We performed efficacy safety assessments based on more than 4.5 years follow-up receiving therapy for KHE. One hundred sixty-seven were analyzed, including 102 (61.1%) Kasabach-Merritt phenomenon (KMP). Follow-up was conducted...
The reconstruction of large-sized soft tissue defects remains a substantial clinical challenge, with adipose engineering emerging as promising solution. acellular dermal matrix (ADM), known for its intricate spatial arrangement and active cytokine involvement, is widely employed scaffold in engineering. Since ADM shares high similarity decellularized matrix, it holds potential substitute tissue. This study explores the adipogenic ability spongy material derived from via vacuum-thermal...
Propranolol, a lipophilic nonselective β-blocker, has recently been reported to be the treatment of choice for select types infantile hemangiomas (IHs). Atenolol is hydrophilic, selective β1-blocker and therefore may not associated with side effects attributable β2-adrenergic receptor blockade lipophilicity. However, efficacy safety atenolol in IH are poorly understood. The aim this study was evaluate proliferating IHs. A 76 infants between ages 5 20 weeks superficial or mixed conducted...
Abstract Background Psychosocial functioning is poor in patients with pectus excavatum (PE). However, a comprehensive understanding of this issue does not exist. The aim study was to assess the severity psychosocial problems as associated PE, well identify its risk factors. Methods A comparative performed at Sichuan Academy Medical Sciences/Sichuan Provincial People's Hospital Chengdu, China. Patients age 6 16 who admitted outpatient department for evaluation or treatment PE were included...
Abstract Multifocal hepatic hemangioma (MHH) is a benign tumor that commonly diagnosed in children with multiple cutaneous infantile hemangiomas (IHs). We present review of all MHH at our institutions. Of the 42 patients, median age presentation was 2.5 months. Thirty-six (85.7%) patients had IHs. Twelve (28.6%) were symptomatic presentation. There no significant association between number and Fourteen (33.3%) received some form treatment for hemangiomas. The most common type oral prednisone...