A5103029933- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Intestinal Malrotation and Obstruction Disorders
- Vascular Malformations and Hemangiomas
- Congenital Anomalies and Fetal Surgery
- Tumors and Oncological Cases
- Gastroesophageal reflux and treatments
- Vascular Tumors and Angiosarcomas
- Hernia repair and management
- Gastrointestinal disorders and treatments
- Metabolism and Genetic Disorders
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Tuberous Sclerosis Complex Research
- Infant Nutrition and Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Histiocytic Disorders and Treatments
- Oral and Maxillofacial Pathology
- Cancer Research and Treatments
- Soft tissue tumor case studies
- Head and Neck Surgical Oncology
- Cancer and Skin Lesions
- Teratomas and Epidermoid Cysts
West China Hospital of Sichuan University
2015-2024
Sichuan University
2013-2023
Guilin University of Electronic Technology
2023
Shanghai Jiao Tong University
2009
Kaposiform hemangioendothelioma (KHE) is an aggressive disease with high morbidity and mortality. The aim of this study was to retrospectively evaluate the efficacy safety sirolimus for treatment progressive KHE. A multicenter, retrospective cohort conducted in patients KHE treated sirolimus. total 52 were analyzed. Thirty-seven (71%) exhibited Kasabach-Merritt phenomenon (KMP) significantly younger than without KMP [95% confidence interval (CI), 14.39-41.61; p < 0.001]. Patients all alone,...
Few studies have reported the clinical features, complications and predictors of Kasabach–Merritt phenomenon (KMP) associated with Kaposiform haemangioendothelioma (KHE). To determine characteristics present at diagnosis to identify features that may aid clinicians in managing KHE. We conducted a cohort study 146 patients diagnosed KHE precursors or lesions were birth 52·1% patients. In 91·8% patients, developed within first year life. The median age was 2·3 months (interquartile range...
Currently, propranolol is the most preferred systemic therapy for problematic infantile hemangiomas (IHs). However, side effects such as bronchial hyperreactivity may be intolerable. The aim of this study was to evaluate frequency, risk factors and management intolerable (ISEs) during therapy. In total, 1260 children were studied. incidence ISEs 2.1% (26 patients). Severe sleep disturbance common reason cessation, accounting 65.4% cases. 23 3 patients received atenolol prednisolone...
Necrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal mortality; effective interventions are lacking with limited understanding pathogenesis NEC. The importance Toll-like receptor 4 (TLR4) signaling in NEC well documented; however, potential mechanisms that regulate enterocyte inflammation and apoptosis remain unclear. aim this study was to characterize role TLR4-mediated development determine major apoptotic pathways regulators process.TLR4-deficient C57BL/10ScNJ...
Abstract Multifocal hepatic hemangioma (MHH) is a benign tumor that commonly diagnosed in children with multiple cutaneous infantile hemangiomas (IHs). We present review of all MHH at our institutions. Of the 42 patients, median age presentation was 2.5 months. Thirty-six (85.7%) patients had IHs. Twelve (28.6%) were symptomatic presentation. There no significant association between number and Fourteen (33.3%) received some form treatment for hemangiomas. The most common type oral prednisone...
To summarize experiences and discuss the reasons for postlaparoscopic indirect inguinal hernia recurrence in children.From June 2008 to 2013, 6120 laparoscopic repairs were performed our hospital involving 5382 males 738 females. The average age was 3.1 years. When pneumoperitoneum established, lens a clamp placed into upper lower edges of umbilicus, respectively. Then on surface projection unclosed internal ring, sled-like needle with suture circled tightened ring at...
Gastro-oesophageal reflux is frequent in chronic airway diseases and considered a trigger for symptoms. In animal models, bilateral vagotomy or muscarinic antagonists prevent the increase resistance microvascular leakage induced by acute oesophageal acid instillation. The present study investigates lung inflammation remodelling an model of gastro-oesophageal disease (GORD), effectiveness pretreatments with tiotropium, atropine dexamethasone. Mice were exposed to twice-daily intra-oesophageal...
The aim of this study was to evaluate the mid-term results laparoscopic Kasai portoenterostomy (LKPE) for biliary atresia (BA) at our hospital.From May 2009 2012, charts infants with BA who underwent LKPE were reviewed retrospectively. clearance jaundice (CJ) as well 3-year, and 5-year survival native liver (SNL) rates analyzed compared those after open (OKPE).Forty-nine patients assigned group A, 40 OKPE B. All in both groups had type III non-syndromic BA, procedures performed by 2...
Laparoscopic Kasai portoenterostomy (LKPE) is performed for biliary atresia (BA). As LKPE a technically demanding operation, learning curve should be defined to guide training. The aim of this study was identify the BA.Metrics perioperative safety and efficiency 100 cases were evaluated. Outcomes followed 67.2 ± 12.1 months. Cumulative sum (CUSUM) analysis used inflexion point corresponding curve. Outcome measures included operative time (ORT), rate clearance jaundice (CJ) survival with...
Abstract Purpose A new novel technique for the treatment of pediatric hypertrophic pyloric stenosis (HPS), transumbilical single-site laparoscopic pyloromyotomy with a single instrument (TUSSLP), was introduced. TUSSLP compared transabdominal three-site (TATSLP) procedure. Methods Patients HPS who underwent and TATSLP between January 2016 September 2020 were assigned to group B, respectively. The descriptive variables, perioperative clinical characteristics postoperative follow-up results...
Abstract Objective To determine whether revision laparoscopic Kasai portoenterostomy (RLKPE) is a viable treatment option for patients with biliary atresia (BA) who had undergone initially successful (ILKPE). Methods The medical records of 312 nonsyndromic BA ILKPE between May 2009 and 2017 were retrospectively reviewed. divided into three groups according to their outcomes after ILKPE: group A: 25 RLKPE; B: 203 required no further surgical intervention; C: 84 failed either died or liver...
Despite surgical treatment, children with biliary atresia (BA) may face many problems which seriously affect their quality of life. However, there is a paucity studies in China examining the life these after BA treatment. This study investigated current status treatment and analyzed influencing factors so as to provide scientific basis for development targeted interventional measures.From May 1 31, 2021, STAR questionnaire method was used conduct cross-sectional surveys following surgery...
The objective of this study was to evaluate the safety and efficacy laparoscopic Ladd's procedure (LL) for intestinal malrotation (IM) in small infants.All patients aged < 6 months with IM who underwent procedures between January 2012 December 2019 were enrolled. perioperative demographics midterm follow-up results retrospectively reviewed compared LL open operation (OL).Fifty-five enrolled analysis. baseline characteristics well matched two groups. rate volvulus similar groups (76.2% vs....
Objective To evaluate the efficacy and safety of oral propranolol versus atenolol in treatment infantile hemangioma (IH). Methods A total 75 infants with IH aged 5-24 weeks were randomly divided into two groups: group (n = 30) orally administrating 2 mg · kg-1·d-1 3 doses daily for 24 consecutive weeks, 45) 1 mg·kg-1·d-1 once a day weeks. After 1-, 4-, 12-, 24-week treatment, followed adverse reactions recorded. In addition, activity was assessed by score (HAS) before after changes...
The aim was to investigate the characteristics, surgical management, and outcomes of asymptomatic patients with antenatally diagnosed choledochal cysts (ADCCs) justify strategy laparoscopic surgery (LS) for them in our hospital.We developed LS ADCCs. Patients ADCCs who underwent or open (OS) during January 2010 2020 were included. recorded symptomatic exclude. All data group OS statistically compared analyzed.Twenty-five received 18 There no significant difference baseline characteristics...
Objective To summarize the techniques and experiences of laparoscopic resection liver tumors in children. Methods From August 2016 to December 2017, 8 cases tumor were performed. There 5 boys 3 girls with an age (6.0±5.3)(1-12) years. The average diameter was (6.0±2.2)(3-9) cm. specific procedures left hemihepatectomy (n=3), lateral lobectomy (n=3) irregular hepatectomy (n=2). Enhanced computed tomography (CT) or magnetic resonance imaging employed for preoperative evaluations. Tumors...
Objective To summarize our experience on precise liver resection for giant pediatric hepatic neoplasms. Methods From January 2009 to February 2012,30 patients underwent technique of neoplasm at West-China hospital Sichuan Universi- ty. The patients,consisting 17 boys and 13 girls,had an average age 5.04 ＋ 3.50 years （range,2 months 14 years）. Hepatic reserve function radiologic study were evaluated carefully before sur- gery. Individualized surgical approach was planned. Postoperative...