A5100410045- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Health and Contraception
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Pregnancy and preeclampsia studies
- Cervical and Thoracic Myelopathy
- Vascular Malformations Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Intracranial Aneurysms: Treatment and Complications
- Maternal and fetal healthcare
- Pregnancy-related medical research
- Intracerebral and Subarachnoid Hemorrhage Research
- Maternal and Perinatal Health Interventions
- Neurofibromatosis and Schwannoma Cases
- Birth, Development, and Health
- Cardiac electrophysiology and arrhythmias
- Immune Cell Function and Interaction
- Assisted Reproductive Technology and Twin Pregnancy
- Medical Imaging and Analysis
- Neurogenetic and Muscular Disorders Research
- Ear Surgery and Otitis Media
Shanghai Jiao Tong University
2015-2025
Hangzhou First People's Hospital
2025
Sichuan University
2025
West China Medical Center of Sichuan University
2020-2025
Lu'an First People's Hospital
2025
Anhui Medical University
2025
Shanghai Children's Medical Center
2023-2025
International Peace Maternity & Child Health Hospital
2014-2024
XinHua Hospital
2021-2024
Army Medical University
2021-2024
Sjögren's syndrome is a chronic autoimmune disease affecting the lacrimal glands and other epithelia. It has been suggested that acinar cells of provoke local responses, leading to when they begin expressing major histocompatibility complex (MHC) class II molecules. We used isopycnic centrifugation phase partitioning resolve compartments participate in traffic between basolateral membranes endomembrane system test hypothesis MHC molecules enter contain potential autoantigens, i.e., La/SSB,...
Ectopic pregnancy (EP) is the leading cause of maternal death during first trimester pregnancy. A better understanding EP risk can help prevent its occurrence. We carried out a multi-center, large-sample, case-control study to evaluate factors for in Shanghai, China.Women who were diagnosed with (n = 2411) and women intrauterine pregnancies 2416) recruited from five hospitals China. Information regarding sociodemographic characteristics; reproductive, gynecological surgical history; previous...
The recommendations for the diagnosis of stage 1 hypertension were recently revised by American Heart Association primarily based on its impact cardiovascular disease risks. Whether newly diagnosed impacts pregnancy complications remain poorly defined. We designed a retrospective cohort study to investigate associations detected in early gestation (<20 weeks) with risks adverse outcomes stratified prepregnancy body mass index. A total 47 874 women singleton live births and blood pressure...
Background and Purpose As the global fertility rate declines, China has issued two three-child policies in past 10 years. Therefore, this study serves to evaluate intention rates related factors couples intending have a second child third child. Methods A cross-sectional survey was conducted mainland from July August 2021. Couples with one or children were invited participate our order collect information about more than possibly factors. Odds ratios (ORs) their corresponding 95% confidence...
This study was designed to clarify whether transplantation of fetal olfactory ensheathing cells (OECs) would affect the clinical course patients with amyotrophic lateral sclerosis (ALS). Thirty-five probable or definite ALS were enrolled from December 2004 September 2006; 15 received OECs and 20 did not receive transplantation. cultured injected into bilateral corona radiata involving pyramidal tracts frontal lobes. The primary end point used indicate effectiveness rate change according...
Endometriosis is a gynecological disease related to menstruation that affects nearly 10% of reproductive-age women. However, so far, there are no reliable diagnostic biomarkers for endometriosis, causing delay in diagnosis 6.7 ± 6.2 years. Menstrual blood non-invasive source endometrial tissue can be analyzed endometriosis. In this study, menstrual samples were collected from women with (n = 8) and without Data Independent Acquisition (DIA)-based mass spectrometry bioinformatic analysis used...
Abstract Soluble human leukocyte antigen‐G (sHLA‐G) has been reported in malignancies and is implicated mediating immune surveillance of tumor. The aim our study to detect serum sHLA‐G levels colorectal cancer determine whether may be helpful distinguishing from benign diseases. Serum were determined using enzyme‐linked immunosorbent assay. Receiver operating characteristic (ROC) curve was used evaluate the feasibility differentiating Median concentrations significantly higher compared...
BackgroundPostmenstrual spotting and chronic pelvic pain after cesarean delivery are associated with the presence of niches. Levonorgestrel intrauterine system (52 mg) hysteroscopic niche resection have been shown to relieve niche-related symptoms at 6 months intervention.ObjectiveThis trial aimed compare effectiveness 52-mg levonorgestrel that in reducing postmenstrual spotting.Study DesignThis randomized, open-label, controlled was conducted a medical center Shanghai, China. Women...
Abstract The precise mechanisms behind early embryonic arrest due to sperm‐related factors and the most effective strategies are not yet fully understood. Here, we present two cases of male infertility linked novel TDRD6 variants, associated with oligoasthenoteratozoospermia (OAT) arrest. To investigate underlying promising therapeutic approaches, Tdrd6 knock‐in knock‐out mice were generated. variant demonstrated OAT arrest, mirroring clinical observations our patients. Sperm from both...
Endometriosis (EM) is highly associated with infertility. The precise mechanism underlying EM-associated infertility remains controversial. This study aimed to investigate the pathogenesis of in women EM by comparing FoxP3+ T regulatory cells (Tregs) expression eutopic endometrium infertile and from healthy fertile women.As a marker Tregs, FoxP3 was analyzed during peri-implantation phase mild (n = 7), advanced 20), normally without 20). mRNA quantitative real-time RT-PCR. protein assessed...
Objective To evaluate the association between risk of ectopic pregnancy (EP) and use common contraceptives during previous current conception/menstrual cycle. Methods A multi-center case-control study was conducted in Shanghai. Women diagnosed with EP were recruited as case group (n = 2,411). intrauterine (IUP) 2,416) non-pregnant women 2,419) matched controls at a ratio 1∶1. Information regarding collected. Multivariate logistic regression analyses performed to calculate odds ratios (ORs)...
Despite limited information on neonatal safety, the transfer of frozen-thawed cleavage-stage embryos with blastomere loss is common in women undergoing vitro fertilization. We aimed to evaluate pregnancy outcomes and safety loss.This prospective, multicenter, cohort study included all embryo (FET) cycles between 2002 2012. Pregnancy subsequent were compared FET intact those loss.A total 12,105 analysis (2259 group 9846 group). The showed significantly poorer respect implantation, pregnancy,...
Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle weakness. It one the most common genetic causes mortality among infants aged less than 2 years. Biomarker research currently receiving more attention, and new candidate biomarkers are constantly being discovered. This review initially discusses evaluation methods commonly used in clinical practice while briefly outlining their respective pros cons. We also describe recent advancements...
The early identification of hemophagocytic lymphohistiocytosis (HLH) in critically ill children with malignancies is challenging. value an activated cytotoxic T-cell profile diagnosing HLH this group patients unknown. Critically who suffered from persistent cytopenia the pediatric intensive care unit were included. Children divided into two groups based on how many clinical diagnostic criteria they fulfilled: M-HLH group, ≥5 criteria; hematologic malignancy (HM) ≤4 criteria. Flow cytometry...
Objective To identify risk factors for ovarian pregnancy (OP) and compare clinical features between OP tubal (TP) patients. Design Case–control study. Setting University hospital. Participants A case–control study was conducted from January 2005 to May 2014. Women diagnosed with were recruited as the case group (n=71), 145 women TP 146 intrauterine (IUP) matched controls at a ratio of 1:2:2. who refused interviews or provided incomplete information excluded. Results lower than in serological...
To discuss the significance and short-term effect of bone puncture technique in transiliac approach to intervertebral endoscopic discectomy for treatment L5/S1 disc herniation.Nineteen patients were diagnosed as herniation treated using (group I), 20 underwent conventional R) [corrected]. Leg pain was evaluated by VAS. MacNab ratings last follow-up recorded evaluate early clinical efficacy, postoperative complications surgical safety. The imaging changes 3 months after surgery observed.One...
Pelvic endometriosis (EM) and adenomyosis (AM) have different effects on the fallopian tube. This study aimed to assess transport capability of tube in women with pelvic EM or AM.Twenty uterine leiomyoma (control group), 20 without (AM group) 35 AM (EM were included. cases further divided into tubal non-tubal subgroups. Ciliary beat frequency (CBF), percentage ciliated cells, smooth muscle contraction measured.CBFs ampulla significantly lower than those control cases; CBFs isthmus group...
The aim of this study was to explore the prevalence and predictors cesarean scar defect (CSD) at 6 weeks postpartum in Shanghai, China.Women scheduled receive a section (CS) were recruited from university hospital. Surgery-related factors, pregnancy complications, routine examinations, perioperative medications, physical signs collected transvaginal ultrasonography performed assess presence CSD postpartum. Multivariate logistic regression applied identify for CSD.A detected 223 514 women...