A5016364609- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- Pregnancy and preeclampsia studies
- Cancer-related gene regulation
- RNA modifications and cancer
- Transcranial Magnetic Stimulation Studies
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Prenatal Screening and Diagnostics
- Cancer survivorship and care
- Apelin-related biomedical research
- Muscle activation and electromyography studies
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- COVID-19 and Mental Health
- Nutrition and Health in Aging
- Spatial Neglect and Hemispheric Dysfunction
- Protein Degradation and Inhibitors
- Spinal Cord Injury Research
- Respiratory Support and Mechanisms
- Psychosomatic Disorders and Their Treatments
- Renin-Angiotensin System Studies
University of Arizona
2019-2024
First Affiliated Hospital of Shihezi University Medical College
2024
Yueyang Hospital
2020-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
Dalian Medical University
2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Ningxia University
2022
The University of Texas MD Anderson Cancer Center
2017-2021
International Peace Maternity & Child Health Hospital
2018-2021
TP53 mutations are highly prevalent in head and neck squamous cell carcinoma (HNSCC) associated with increased resistance to conventional treatment primarily consisting of chemotherapy radiation. Restoration wild-type p53 function TP53-mutant cancer cells represents an attractive therapeutic approach has been explored recent years. In this study, the efficacy a putative reactivator called COTI-2 was evaluated HNSCC lines different status.Experimental Design: Clonogenic survival assays...
Background Coronavirus disease 2019 (COVID-19) has progressively impacted our daily lives, resulting in unexpected physical and mental stress on medical staff. This study is designed to investigate the levels of risk factors for burnout, depression, anxiety, insomnia among staff during COVID-19 epidemic breakout Shanghai, China. Methods cross-sectional survey was conducted from May 1 31, 2022, who were frontline Shanghai different institutions. The MBI-HSS used assess PHQ-9, GAD-7 ISI...
Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that promote cancer cell invasive growth and metastasis, yet the mechanisms mediating these functions still largely remain elusive. We show here overexpression of GOF G245D other mutants enhances p53-deficient head neck squamous carcinoma (HNSCC) UM-SCC-1 cells both in vitro three-dimensional culture an vivo orthotopic nude mouse model HNSCC through a novel transcription-independent mechanism. demonstrate expression...
We design this study to detect levels of Elabela (ELA) and Apelin (APLN) in women with without gestational diabetes mellitus (GDM) the second third trimesters, identify whether there is any association between ELA, APLN, metabolic parameters. Seventy-nine GDM 80 control subjects trimester 87 88 healthy were included. In trimester, lower ELA [(14.1 versus 16.9) ng/ml, p = .025] higher APLN [(1021.8 923.5) pg/ml, .046] observed patients compared controls. positively correlated fasting plasma...
Background: Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologic neutralizes the TLR4 ligand and DAMP, eNAMPT (extracellular nicotinamide phosphoribosyltransferase), was shown to reduce septic shock/VILI-induced porcine lung injury when delivered 2 h after onset. We now examine mAb efficacy on acute kidney (AKI) fluid...
Purpose: Inflammation triggers a metabolic shift in macrophages from oxidative phosphorylation to glycolysis, phenomenon known as the Warburg effect. This reprogramming worsens inflammation and cascades into organ damage. Angiotensin-(1-7) [Ang-(1-7)], small molecule, has demonstrated anti-inflammatory properties. study investigates whether Ang-(1-7) mitigates LPS-induced septic mice by regulating effect immune metabolism. Methods: The induced with LPS vitro measured inflammatory factors...
Purpose: The cure rate for patients with advanced head and neck squamous cell carcinoma (HNSCC) remains poor due to resistance standard therapy primarily consisting of chemoradiation. As mutation TP53 in HNSCC occurs 60% 80% non-HPV-associated cases is turn associated these treatments, more effective therapies are needed. In this study, we evaluated the efficacy a regimen combining vorinostat AZD1775 cells variety p53 mutations.Experimental Design: Clonogenic survival assays an orthotopic...
Abstract Context Maternal obesity increases the risk of preterm delivery. Obesity is known to be associated with altered lipid metabolism. Objective To investigate associations between high maternal triglyceride (mTG) levels during early pregnancy and risks delivery stratified by body mass index (BMI). Design Retrospective cohort study. Setting University-based maternity center. Patients 49,612 women singleton who underwent fasting serum screening pregnancy. Main Outcome Measures Risk...
Despite advances in surgery, chemotherapy, and radiation, there are limited treatment options for advanced head neck squamous cell carcinoma (HNSCC) survival remains very poor. Therefore, effective therapies desperately needed. Recently, selective exploitation of DNA damage replication stress responses has become a novel approach cancer treatment. Wee1 kinase Rad51 recombinase two proteins involved regulating homologous recombination repair cells. In this study, we investigated the combined...
Human and preclinical studies of sulfur mustard (SM)-induced acute chronic lung injuries highlight the role unremitting inflammation. We assessed utility targeting novel DAMP TLR4 ligand, eNAMPT (extracellular nicotinamide phosphoribosyltransferase), utilizing a humanized mAb (ALT-100) in rat models SM exposure.
Assisted reproductive technology (ART) might induce adverse pregnancy outcomes and increase the risk of metabolic diseases in offspring' later life with unknown reasons. Here we evaluated global methylation level profile fetal tissue from elective terminations (ETP) after natural conception multifetal reduction (MFPR) vitro fertilization embryo transfer (IVF-ET).Global levels were comparable between ETP group MFPR IVF-ET group. The lower hypermethylated regions than group, while higher...
Recent studies indicate that microglia and monocyte-derived macrophages (MDMs) have different roles in diseases such as stroke spinal cord injury, yet their respective polarized phenotypes remain unclear ischemia/reperfusion injury (SCIRI).We established a mouse model of SCIRI by transient aortic occlusion followed reperfusion. Basso scale (BMS) scores were used to test the locomotor functions. The histopathological changes assessed hematoxylin-eosin staining NF-200 immunohistochemistry....
Iron deposition in the brain begins early multiple sclerosis (MS) and continues unabated. Ferrous iron is toxic to neurons, yet therapies used MS do not counter neurotoxicity. Extracts of Hibiscus sabdariffa (HS) are many cultures for medicinal purposes. We collected a distinct HS extract found that it abolished killing neurons by culture; medications were ineffective when similarly tested. Neuroprotection was due chelation or anthocyanin content. In free radical scavenging assays,...
Oral squamous cell carcinoma (OSCC) develops through the multistep malignant progression of epithelium. This process can be prevented by PD-1 blockade in a mouse model for oral carcinogenesis. OSCCs exhibit high incidence p53 mutations that confer oncogenic gain-of-function (GOF) activities promote resistance to standard therapies and poor clinical outcomes. To determine whether epithelial modulate anti-PD-1-mediated cancer immunoprevention, we generated models carcinogenesis exposing mice...
Transcranial direct current stimulation (tDCS) is a type of non-invasive brain technique that has proven effective for neuropsychiatric disorders. Generalized anxiety disorder (GAD) and depression are common psychiatric disorders often comorbid, meaning they occur simultaneously. Current evidence supports the value tDCS GAD. The objectives this report to explore effect on clinical symptoms cerebral function in patient with comorbid GAD depression.Our subject was semiprofessional athlete...
Tacr2 is one of the G protein-coupled receptors(GPCRs) that mediate biological actions tachykinins. It abundantly expressed in gastrointestinal (GI) system and thought to play an important role GI motility, secretion, visceral sensitivity. Previously, physiological pathophysiological functions were mainly studied using selective agonists or antagonists. Here, we seek investigate effect disruption mice provide further insights.The knockout generated by homologous recombination phenotypic...
IntroductionAssisted reproductive technology (ART) treatment is a risk factor for pregnancy-related venous thromboembolism (VTE). This study aims to explore the factors elevated fibrin (fibrinogen) degradation products (FDPs), an indicator of hypercoagulability, in late pregnancy among women who underwent ART treatment.Materials and methodsThis retrospective case-control recruited 227 spontaneously conceived 214 gave birth. A subgroup analysis pregnant after was performed. 156 with FDP...
To investigate the value of two-dimensional (2D) ultrasound combined with three-dimensional power Doppler (3D-PD) in prediction macrosomia early pregnancy.
Objective To evaluate the effect of pressing needle therapy on depression, anxiety, and sleep in patients recovering from COVID-19, to provide a more effective convenient treatment for sequelae COVID-19. Methods A total 136 COVID-19 were randomized into group (68 cases) control cases, with one case dropping out). The received therapy, while sham three times week 4 weeks. Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), Insomnia Severity Index (ISI) used...