A5107722472- Gastrointestinal motility and disorders
- Ion Transport and Channel Regulation
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Advanced Battery Technologies Research
- Neuroscience of respiration and sleep
- Sulfur Compounds in Biology
- Supercapacitor Materials and Fabrication
- Obstructive Sleep Apnea Research
- Gastroesophageal reflux and treatments
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ear Surgery and Otitis Media
- Insect and Arachnid Ecology and Behavior
- Infant Health and Development
- Cancer Research and Treatments
- Diet and metabolism studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune cells in cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Diabetes Treatment and Management
- Hearing Loss and Rehabilitation
Sun Yat-sen University
2024
Beijing Biocytogen (China)
2023-2024
Shanghai Jiao Tong University
2011-2023
Qingdao Agricultural University
2023
Lanzhou University of Technology
2020-2022
University of Nevada, Reno
2015-2022
National Institute of Clean and Low-Carbon Energy
2022
Lanzhou City University
2021
Lithium Power (United States)
2021
Shandong Jiaotong University
2021
Abstract Aphids exhibit unique attributes, such as polyphenisms and specialized cells to house endosymbionts, that make them an interesting system for studies at the interface of ecology, evolution development. Here we present a comprehensive characterization developmental genes in pea aphid, Acyrthosiphon pisum , compare our results other sequenced insects. We investigated involved fundamental processes establishment body plan organogenesis, focusing on transcription factors components...
Significance The peristaltic reflex elicits colonic migrating motor complexes (CMMCs) that are thought to be generated by enteric excitatory neurons stimulating smooth muscle cells (SMCs). We found atropine did not block CMMCs and present a concept showing poststimulus responses following nitrergic in interstitial of Cajal (ICC) responsible for initiation CMMCs. Ca 2+ transients ICC inhibited stimulation. After the inhibitory period, increased, activating currents conducted SMCs initiate...
Abstract The insulin and insulin‐like growth factor (IGF) signalling (IIS) pathway in the honey bee ( Apis mellifera ) is linked to reproductive division of labour foraging behaviour. Two receptor genes are present released genomes other social hymenopterans. Limited information available on IIS role ants. predicted sequences from recently draft genome fire ant Solenopsis invicta (Hymenoptera: Formicidae) incomplete biologically significant data also lacking. To elucidate ant, two putative...
Interstitial cells of Cajal (ICC) from murine colonic muscles express genes encoding inwardly rectifying K+ channels. Transcripts Kcnj2 (Kir2.1), Kcnj4 (Kir2.3), Kcnj14 (Kir2.4), Kcnj5 (Kir3.4), Kcnj8 (Kir 6.1) and Kcnj11 (Kir6.2) were found in ICC. A conductance with properties consistent Kir2 channels was observed ICC but not smooth muscle (SMC). Despite expression gene transcripts, G-protein gated channel (Kir3) KATP (Kir6) currents resolved is a prominent SMC. antagonist caused...
The construction of an optimized electrolyte system compatible with layered transition metal (TM) oxides is great importance to advanced sodium‐ion batteries (SIBs). Herein, a low‐cost iron‐containing manganese‐based cathode material Na 0.67 Ni 0.15 Fe 0.2 Mn 0.65 O 2 (N‐NFM) prepared through improved coprecipitation method. Then, the chemical properties interfaces between N‐NFM and organic liquid electrolytes based on NaClO 4 NaPF 6 are investigated, respectively. Results show that...
Key points Activation of protease‐activated receptors (PAR) regulates gastrointestinal (GI) motility but little is known about the cells and mechanisms in GI muscles responsible for PAR responses. Using mouse cells, we found high levels F2r F2rl1 PAR‐encoding genes expressed purified platelet‐derived growth factor α‐positive (PDGFRα + ) comparison to other colonic muscles. PAR1 PAR2 agonists caused transient hyperpolarization relaxation muscles, with responses followed by excitation. The...
To investigate the distribution and function of interstitial cells Cajal (ICCs) platelet-derived growth factor receptor-α positive (PDGFRα+) in proximal distal colon.The comparison colonic transit ends was performed by migrating motor complexes (CMMCs). The tension smooth muscle examined spontaneous contractile experiments with both strip tied a silk thread. Intracellular recordings were used to assess electrical field stimulation (EFS)-induced inhibitory junction potentials (IJP) on muscle....
Genetic screening of newborns for deafness plays an important role in elucidating the etiology deafness, diagnosing it early, and intervening it. has been conducted 11 years Beijing. It started with a chip to screen 9 variants 4 genes 2012; screened 15 those 2018, now screens 23 genes. In current study, comparative analysis three protocols follow-up infants pathogenic was performed. The rates detection hearing test results were analyzed. Subjects 493,821 born at 122 maternal child care...
Abstract Background Hydrogen sulfide ( H 2 S ) has been shown to have an excitatory effect on gastric motility, but the underlying molecular mechanism is unclear. In this study, we aimed investigate possible targets of and determine how affects its target proteins during ‐induced contraction. Methods Patch‐clamp potentiometric fluorescence dye were utilized measure electrophysiological changes. The Biotin‐switch assay was detect protein S‐sulfhydration. isometric tension measurement...
Abstract Background A major complication related to gastrointestinal ( GI ) symptoms in diabetic patients is chronic constipation. Constipation has serious negative impacts on quality of life; however, without a comprehensive understanding the disease, currently available treatments cannot provide cure. Platelet‐derived growth factor receptor alpha‐positive cells PDGFR α + cells), which form SIP syncytium with interstitial Cajal and smooth muscle cells, play important roles motility. In...
Concurrent screening has been proven to provide a comprehensive approach for management of congenital deafness and prevention ototoxicity. The SLC26A4 gene is associated with late-onset hearing loss great clinical concern. For much earlier detection newborns deafness-causing mutations in the gene, Beijing Municipal Government launched chip optimized genetic 15 variants 4 genes causing based on screen 9 genes, 6 have now added. To ascertain advantage including trends concurrent were analyzed...
The contraction of gastrointestinal (GI) smooth muscles is regulated by both Ca(2+)-dependent and Ca(2+) sensitization mechanisms. Proline-rich tyrosine kinase 2 (Pyk2) involved in the depolarization-induced vascular muscle via a pathway. However, role Pyk2 GI unclear. spontaneous colonic was measured using isometric force transducers. Protein phosphorylation levels were determined western blotting. protein expressed tissue, contractions inhibited PF-431396, inhibitor, presence tetrodotoxin...
Purpose To investigate the role of endogenous hydrogen sulfide (H2S) in partial obstruction-induced dysfunction interstitial cells Cajal (ICC) mice ileum. Materials and Methods Partial intestinal obstruction was induced surgically male imprinting control region (ICR) mice. ICC networks were studied by Immunohistochemistry. Electrical activity recorded intracellular recording techniques. The expression phenotype marker c-kit receptor tyrosine kinase (c-kit), membrane binding stem cell factor...
Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO) mouse model to investigate the changes interstitial and correlation with motility.Western blot technique was employed observe protein expressions Kit, platelet-derived growth factor receptor-α (Pdgfra), Ca2+-activated Cl- (Ano1) channels, small conductance Ca2+-...