A5090256243- Developmental Biology and Gene Regulation
- Tardigrade Biology and Ecology
- Protist diversity and phylogeny
- Neurobiology and Insect Physiology Research
- Marine Invertebrate Physiology and Ecology
- Marine Ecology and Invasive Species
- Insect and Arachnid Ecology and Behavior
- Genomics and Phylogenetic Studies
- Biocrusts and Microbial Ecology
- Spider Taxonomy and Behavior Studies
- Marine Biology and Ecology Research
- Subterranean biodiversity and taxonomy
- Silk-based biomaterials and applications
- Animal Behavior and Reproduction
- Wnt/β-catenin signaling in development and cancer
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic diversity and population structure
- Genetics, Aging, and Longevity in Model Organisms
- Insect Resistance and Genetics
- Animal Genetics and Reproduction
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- Venomous Animal Envenomation and Studies
- Parasite Biology and Host Interactions
Uppsala University
2016-2025
Hôpitaux Universitaires de Strasbourg
2016
Université de Strasbourg
2016
University of Cologne
2003-2008
The duplication of genes can occur through various mechanisms and is thought to make a major contribution the evolutionary diversification organisms. There increasing evidence for large-scale in some chelicerate lineages including two rounds whole genome (WGD) horseshoe crabs. To investigate this further, we sequenced analyzed common house spider Parasteatoda tepidariorum. We found pervasive both coding non-coding spider, clusters Hox genes. Analysis synteny conservation across P....
Abstract Background The Wnt genes encode secreted glycoprotein ligands that regulate a wide range of developmental processes, including axis elongation and segmentation. There are thirteen subfamilies in metazoans this gene diversity appeared early animal evolution. loss appears to be common insects, but little is known about the repertoire other arthropods, moreover expression function these have only been investigated few protostomes outside relatively -poor model species Drosophila...
Onychophora is a relatively small phylum within Ecdysozoa, and considered to be the sister group Arthropoda. Compared arthropods, that have radiated into countless divergent forms, onychophoran body plan overall comparably simple does not display much in-phylum variation. An important component of arthropod morphological diversity consists variation tagmosis, i.e. grouping segments functional units (tagmata), this in turn correlated with differences expression patterns Hox genes. How these...
Abstract Aphids exhibit unique attributes, such as polyphenisms and specialized cells to house endosymbionts, that make them an interesting system for studies at the interface of ecology, evolution development. Here we present a comprehensive characterization developmental genes in pea aphid, Acyrthosiphon pisum , compare our results other sequenced insects. We investigated involved fundamental processes establishment body plan organogenesis, focusing on transcription factors components...
Sox (Sry-related high-mobility-group box) genes represent important factors in animal development. Relatively little, however, is known about the embryonic expression patterns and thus possible function(s) of during ontogenesis panarthropods (Arthropoda+Tardigrada+Onychophora). To date, studies have been restricted exclusively to higher insects, including model system Drosophila melanogaster, with no comprehensive data available for any other arthropod group, or tardigrade onychophoran. This...
Gene duplication generates new genetic material that can contribute to the evolution of gene regulatory networks and phenotypes. Duplicated genes undergo subfunctionalization partition ancestral functions and/or neofunctionalization assume a function. We previously found there had been whole genome (WGD) in an ancestor arachnopulmonates, lineage including spiders scorpions but excluding other arachnids like mites, ticks, harvestmen. This WGD was evidenced by many duplicated homeobox genes,...
Abstract Evolution and development of the arthropod head are heavily debated topics often referred to as “The problem” (AHP) or “Endless dispute”. One aspect AHP concerns evolutionary origin homology most anterior segments, pre-gnathal segments (PGS), that associated with tripartite brain arthropods. It has been suggested PGS could have evolved independently from build rest body. argument supporting this hypothesis is patterned by an initial transverse stripe hedgehog ( hh )-expression...
Summary The activation of pair rule genes is the first indication metameric organization Drosophila embryo and thus forms a key step in segmentation process. There are two classes : primary that directly activated by maternal gap secondary rely on input from genes. Here we analyze orthologs spider Cupiennius salei . expression patterns gene can be subdivided three groups: even‐skipped runt‐1 stripes start at posterior end growth zone their ends before reach anterior zone, while hairy...
In arthropods, such as Drosophila melanogaster, the leg gap genes homothorax (hth), extradenticle (exd), dachshund (dac), and Distal-less (Dll) regionalize legs in order to facilitate subsequent segmentation of legs. We have isolated homologs all four from onychophoran Euperipatoides kanangrensis studied their expression. show that regionalization takes place onychophorans even though they represent simple nonsegmented appendages. This implies evolved for a different function was only later...
The Onychophora are a probable sister group to Arthropoda, one of the most intensively studied animal phyla from developmental perspective. Pioneering work on fruit fly Drosophila melanogaster and subsequent investigation other arthropods has revealed important roles for Wnt genes during many processes in these animals.We screened embryonic transcriptome onychophoran Euperipatoides kanangrensis found that at least 11 expressed embryogenesis. These represent 13 known subfamilies genes.Many...
Abstract Whole-genome duplications (WGDs) have occurred multiple times during animal evolution, including in lineages leading to vertebrates, teleosts, horseshoe crabs, and arachnopulmonates. These dramatic events initially produce a wealth of new genetic material, generally followed by extensive gene loss. It appears, however, that developmental genes such as homeobox genes, signaling pathway components microRNAs are frequently retained duplicates (so-called ohnologs) following WGD. not...
SUMMARY The early cleavage up to gastrulation is described here for the priapulid worm Priapulus caudatus , contradicting and clarifying earlier partial reports on this topic. pattern highly symmetrical, total, subequal, radial, stereotypical. Gastrulation intermediate between epiboly invagination, mesendoderm may be derived from both cells of first cleavage, thus differing significantly in its origin that many other protostomes. Priapulids occupy an increasingly important position studies...
Segmentation is a hallmark of the arthropods; most knowledge about molecular basis arthropod segmentation comes from work on fly Drosophila melanogaster. In this species hierarchic cascade genes subdivides blastoderm stepwise into single segment wide regions. However, in derived feature since all segments form virtually simultaneously. Conversely, vast majority arthropods posterior one at time pre-segmental zone. The pair rule (PRGs) comprise an important level gene and are indeed first that...
One set of the developmentally important Doublesex and Male-abnormal-3 Related Transcription factors (Dmrt) is subject intense research, because their role in sex-determination sexual differentiation. This likely non-monophyletic group Dmrt genes represented by Drosophila melanogaster gene (Dsx), Caenorhabditis elegans (Mab-3) gene, vertebrate Dmrt1 genes. However, other members family are much less well studied, arthropods, including model organism melanogaster, data on these virtually...
Abstract The Wnt genes represent a large family of secreted glycoprotein ligands that date back to early animal evolution. Multiple duplication events generated set 13 families which 12 are preserved in protostomes. Embryonic expression patterns (Wnt-patterning) complex, representing the plentitude functions these play during development. Here, we comprehensively investigated embryonic from three species spiders covering both main groups true spiders, Haplogynae and Entelegynae, mygalomorph...
The common house spider Parasteatoda tepidariorum represents an emerging new model organism of arthropod evolutionary and developmental (EvoDevo) studies. Recent technical advances have resulted in the first single-cell sequencing (SCS) data on this species allowing deeper insights to be gained into its early development, but mid-to-late stage embryos were not included these pioneering
Abstract Background Spiders evolved different types of eyes, a pair primary eyes that are usually forward pointing, and three pairs secondary typically situated more posterior lateral on the spider’s head. The best understanding arthropod eye development comes from vinegar fly Drosophila melanogaster , main model organism, also larval ocelli compound imago. gene regulatory networks underlie in this species well investigated revealing conserved core network, but show several differences...