A5100682562- Protein Hydrolysis and Bioactive Peptides
- Proteins in Food Systems
- Biochemical effects in animals
- Cardiac Fibrosis and Remodeling
- GDF15 and Related Biomarkers
- Computational Drug Discovery Methods
- Signaling Pathways in Disease
- Cardiovascular Function and Risk Factors
- Antibiotic Resistance in Bacteria
- Heart Failure Treatment and Management
- Meat and Animal Product Quality
- Gut microbiota and health
- Infant Nutrition and Health
- Pharmacological Effects of Natural Compounds
- Insect Utilization and Effects
- Hearing Loss and Rehabilitation
- Advanced Glycation End Products research
- Food Chemistry and Fat Analysis
- Hearing, Cochlea, Tinnitus, Genetics
- Supramolecular Self-Assembly in Materials
- Pharmaceutical and Antibiotic Environmental Impacts
- Probiotics and Fermented Foods
- Traditional Chinese Medicine Studies
- Antimicrobial Peptides and Activities
- Tuberculosis Research and Epidemiology
Hainan University
2025
Shandong University of Traditional Chinese Medicine
2020-2025
Capital Medical University
2022-2025
Beijing Tongren Hospital
2022-2025
Yale University
2025
Jilin University
2011-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
IIT Research Institute
2023
Ministry of Education of the People's Republic of China
2022-2023
Beijing Institute of Neurosurgery
2022-2023
In this study, novel saltiness/saltiness enhancing peptides VESQTNGIIR, NQITKPNDVY, and DEDTQAMP were identified from the hen egg proteins via virtual enzymatic, molecular docking, electronic tongue analysis. Their saltiness enhancement effect was analyzed by e-tongue Saltiness rates of peptide VESQTNGIIR 47.24 %, 95.28 % 105.94 those NQITKPNDVY 32.40 70.16 71.25 at salt reduction concentrations 25 35 45 respectively. 5.83 11.24 concentrations, Molecular docking demonstrated that Glu286,...
BackgroundIschemic heart failure (IHF) is a serious complication after acute myocardial infarction (AMI). Understanding the mechanism of IHF AMI will help us conduct early diagnosis and treatment.MethodsWe obtained dataset GSE66360 GSE57338 from GEO database, screened overlapping genes common to both diseases through WGCNA analysis. Subsequently, we performed GO KEGG enrichment analysis on elucidate IHF. Machine learning algorithms are also used identify key biomarkers. Finally, immune cell...
To explore the trend of hearing changes in infants with
Abstract Aims Heart failure (HF) is an important public health problem worldwide, and programmed cell death (PCD) plays a crucial role in its pathologic process. This study aims to identify the hub genes associated with HF through PCD order better understand pathogenesis of improve diagnosis treatment. Methods results The gene expression dataset was obtained from GEO database. Bioinformatics machine learning algorithms were utilized screen key PCD‐related genes, diagnostic model constructed...
Abstract: A bioactive peptide Arg–Val–Pro–Ser–Leu (RVPSL) obtained from egg white protein was characterized by LC‐MS and further chemically synthesized the Fmoc solid phase method investigated in terms of its angiotensin converting enzyme (ACE)‐inhibitory activity, antioxidant property, anticoagulation as well stability a simulated gastrointestinal digestion. The exhibited an ACE‐inhibitory activity with IC 50 value 20 μM. Also, could efficiently quench (1,1)‐diphenyl‐2‐picrylhydrazyl free...
Summary To identify novel antioxidant peptides from egg‐white protein and investigate mechanism, the hydrolysate of was purified by ultrafiltration a Sephadex G‐15 column. The VYLPR, EVYLPR, VEVYLPR VVEVYLPR were identified fraction with highest activity. Results showed that peptide VYLPR exhibited strongest protective effect on HEK‐293 cells. viability cells recovered to 97.45 ± 1.98% pre‐treatment 20 μ m VYLPR. We further investigated mechanism. results could inhibit lipid peroxidation...
Heart failure is the final destination of most cardiovascular diseases, and its complex molecular mechanisms remain largely uncertain. This study aimed to systematically investigate underlying diagnostic therapeutic targets heart using bioinformatics. We obtained 8 healthy samples from GSE8331 GSE76701. After removing batch effect, we performed a differential analysis on it 185 differentially expressed ID. The results enrichment showed that were mostly related immune, inflammation,...