A5101917225- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Congenital Ear and Nasal Anomalies
- Eosinophilic Disorders and Syndromes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet, Metabolism, and Disease
- Immune cells in cancer
- Pressure Ulcer Prevention and Management
- Renin-Angiotensin System Studies
- Vascular Anomalies and Treatments
- Macrophage Migration Inhibitory Factor
- Reproductive System and Pregnancy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Otitis Media and Relapsing Polychondritis
- Viral Infections and Vectors
- Hormonal Regulation and Hypertension
- Electrolyte and hormonal disorders
- Potassium and Related Disorders
- Mosquito-borne diseases and control
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Apelin-related biomedical research
Chongqing Medical University
2020-2024
Second Affiliated Hospital of Chongqing Medical University
2020-2024
South China Agricultural University
2024
Army Medical University
2018-2024
Southwest Hospital
2018-2024
Dalian Medical University
2020-2024
Second Military Medical University
2016
Changhai Hospital
2016
Purpose: Angiotensin 1– 7 [Ang-(1-7)] has been identified as an important anti-inflammatory and anti-fibrotic factor. This study determined how the ACE2-Ang-(1-7)-Mas axis affected M1/M2 macrophage polarization thus contributed to processes in cecal ligation puncture (CLP)-induced inflammation model. Materials Methods: ELISA, western blotting, qRT-PCR were used verify that Ang-(1-7) decreased expression of pro-inflammatory cytokines increased cytokines. The differentiation macrophages was...
Diabetes mellitus (DM) is considered as a risk factor for the progress of liver diseases. After tissue damage, there highest amplitude ubiquitously sterile inflammatory response in liver, resulting major clinical consequence concerning high prevalence steatohepatitis DM patients. This study aimed to investigate inhibitory efficacy dapagliflozin (DAPA), sodium glucose cotransporter-2 (SGLT2) inhibitor, on experimental with DM.DM-steatohepatitis model was established by dual intraperitoneal...
Objective . To investigate the microbial distribution and drug susceptibility among diabetic foot ulcers (DFUs) with different Wagner grades between acute chronic DFUs Methods We enrolled 428 DFU patients who were hospitalized treated in Southwest Hospital. collected deep ulcer secretion for culture tests analyzed results. reexamined 67 poor anti-infection efficacy species. Results : The 354 positive samples included 201 cases (56.8%) of single-pathogen infections 153 (43.2%)...
Purpose: Inflammation triggers a metabolic shift in macrophages from oxidative phosphorylation to glycolysis, phenomenon known as the Warburg effect. This reprogramming worsens inflammation and cascades into organ damage. Angiotensin-(1-7) [Ang-(1-7)], small molecule, has demonstrated anti-inflammatory properties. study investigates whether Ang-(1-7) mitigates LPS-induced septic mice by regulating effect immune metabolism. Methods: The induced with LPS vitro measured inflammatory factors...
Barium is a heavy divalent alkaline earth metal that has been known as muscle poison. can cause human toxicity, which may lead to significant hypokalemia and have serious consequences. This paper reports case of unprecedented barium intoxication in the patient, who suffered from depression, swallowed at least 3.0 g chloride commit suicide. On admission, patient presented with nausea, vomiting, stomach burning feeling, dizziness, weakness. Emergency biochemical testing showed was suffering...
Background. Chronic diabetic foot ulcer (DFU) is one of the most intractable complications diabetes mellitus (DM). Its pathogenesis complex, and uncontrolled chronic inflammation an important factor. Endothelial overexpressed lipopolysaccharide-associated factor 1 (EOLA1) discovered in our laboratory intracellular protein with function inflammatory regulation. This study was aimed at observing expression EOLA1 DFU skin tissues its relationship exploring possible role mechanism. Methods . The...
Pulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease characterized by diffuse alveolar inflammation, fibroblast differentiation, and the excessive deposition of extracellular matrix. During progression PF, redox imbalance caused reactive oxygen species (ROS) production can result in further destruction tissue. At present, data on role NADPH oxidase-4 (Nox4)-nuclear factor erythroid 2-related 2 (Nrf2) PF are limited. The angiotensin (1-7) [Ang-(1-7)]/Mas axis protective...