A5003519977- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Metabolism, Diabetes, and Cancer
- Diabetic Foot Ulcer Assessment and Management
- Pancreatic function and diabetes
- PI3K/AKT/mTOR signaling in cancer
- Diagnosis and Treatment of Venous Diseases
- Advanced MRI Techniques and Applications
- Diabetes Management and Research
- Retinal Diseases and Treatments
- Peripheral Artery Disease Management
- Wound Healing and Treatments
- Cancer Risks and Factors
- Antioxidant Activity and Oxidative Stress
- Sirtuins and Resveratrol in Medicine
- Atherosclerosis and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Education
- Galectins and Cancer Biology
- Thyroid Disorders and Treatments
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Invertebrate Immune Response Mechanisms
Army Medical University
2016-2025
Southwest Hospital
2015-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2024
Chongqing Medical University
2023-2024
Background . Our study aimed to observe the effect of sodium glucose cotransporter-2 (SGLT2) inhibitor dapagliflozin on diabetic atherosclerosis and investigate subsequent mechanism. Methods Aortic was induced in streptozotocin ApoE −/− mice by feeding with high-fat diet, administrated intragastrically for 12 weeks as treatment. Effects indices fat metabolism, IL-1 β , IL-18, NLRP3 protein levels, reactive oxygen species (ROS) were measured. The evaluated oil red O hematoxylin-eosin...
Diabetes mellitus (DM) is considered as a risk factor for the progress of liver diseases. After tissue damage, there highest amplitude ubiquitously sterile inflammatory response in liver, resulting major clinical consequence concerning high prevalence steatohepatitis DM patients. This study aimed to investigate inhibitory efficacy dapagliflozin (DAPA), sodium glucose cotransporter-2 (SGLT2) inhibitor, on experimental with DM.DM-steatohepatitis model was established by dual intraperitoneal...
BACKGROUND Serum retinol-binding protein (RBP) is the primary transport of circulating vitamin A. RBP has a crucial role in maintaining nutrient metabolism and physiologic homeostasis. Several studies have indicated that serum participates progression diabetes diabetes-related complications. However, impact on lower limb atherosclerosis not been determined individuals with type 2 mellitus (T2DM). AIM To determine association between T2DM. METHODS This retrospective study enrolled 4428...
Objective . To investigate the microbial distribution and drug susceptibility among diabetic foot ulcers (DFUs) with different Wagner grades between acute chronic DFUs Methods We enrolled 428 DFU patients who were hospitalized treated in Southwest Hospital. collected deep ulcer secretion for culture tests analyzed results. reexamined 67 poor anti-infection efficacy species. Results : The 354 positive samples included 201 cases (56.8%) of single-pathogen infections 153 (43.2%)...
Beta 2-microglobulin (β2-MG) is a component of the class I major histocompatibility complex (MHCI) and has recently been reported to be involved in type 2 diabetes mellitus (T2DM) cardiovascular disease. However, association β2-MG with left ventricular hypertrophy (LVH) T2DM patients remains unknown. This study aims investigate correlation between serum LVH patients.
Background . Diabetic cardiomyopathy (DCM) is always accompanied with alteration of left ventricular structure and function. The aims this study were to assess the structural remodelling in patients DCM by cardiovascular magnetic resonance (CMR) correlation severity DCM. Methods Twenty-five (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">53.8</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">8.8</mml:mn></mml:math>years, 52.0% males) thirty-one...
Background: To investigate whether lower limb vascular intervention or autologous platelet-rich gel (APG) treatment would benefit diabetic extremity arterial disease (LEAD) patients with foot ulcers. Methods: A total of 82 LEAD ulcers were recruited and divided into three groups: group (30 received basal treatment), B (21 APG C (31 treatment). All underwent routine follow-up visits for 6 months. The baseline characteristics parameters examined. After treatment, changes in all from recorded....
To explore the mechanism that exenatide reduces cardiomyocyte apoptosis via adiponectin pathway in vitro.Cardiomyocytes were randomly divided into control group (group C), diabetic D), + treatment DE), APPL1 overexpression OE), and knock-down KD). After 48 h culture, rate, level cell culture fluid, expression levels of APPL1, p-AMPK, PPARα NF-κB detected by TUNEL, ELISA, Western blotting, respectively.Compared to C, rate was markedly increased, decreased, p-AMPK down-regulated up-regulated D...
Islet β cell apoptosis plays an important role in type 2 diabetes. We previously reported that Par-4-mediated islet is induced by high-glucose/fatty acid levels. In the present study, we show Par-4, which levels, interacts with and inhibits TERT cytoplasm then translocates to nucleus. Par-4 also inhibited Akt phosphorylation, leading apoptosis. cells under conditions knocked out diabetic mice, led up-regulation of improvement rate. phosphorylation aggressive addition, biological film...
Our research group firstly discovered endothelial-overexpressed lipopolysaccharide-associated factor 1 ( EOLA1 , GenBank number AY074889) as a lipopolysaccharide (LPS) responsive gene in ECV304 cells. The previous studies have further demonstrated the association of with metallothionein 2A (MT2A), while role during LPS-induced inflammatory response cells is unknown. In this report, we determined subcellular localization and regulatory capacity on vascular cell adhesion molecule-1 (VCAM-1) to...
This study investigated the effects of metformin on breast density in overweight/obese premenopausal women.Overweight/obese women (n=120) were randomly assigned to or placebo group, and all received lifestyle interventions. The outcomes included weight, BMI, FPG, FIN, glucose, HOMA-IR, LDL-C, HDL-C, TG, TC, SBP, DBP, FSH, E, AD, BIRADS grade, incidence cancer was assessed by pathological biopsy grade greater than 4.In total, 120 completed 1-year trial. Seven patients had a 4, including 5 who...
Background. Chronic diabetic foot ulcer (DFU) is one of the most intractable complications diabetes mellitus (DM). Its pathogenesis complex, and uncontrolled chronic inflammation an important factor. Endothelial overexpressed lipopolysaccharide-associated factor 1 (EOLA1) discovered in our laboratory intracellular protein with function inflammatory regulation. This study was aimed at observing expression EOLA1 DFU skin tissues its relationship exploring possible role mechanism. Methods . The...
The purpose of this study was to evaluate the sex differences in myocardial structure, tissue characteristics, and function type 2 diabetes mellitus (T2DM) patients. A total 62 T2DM patients 40 controls were prospectively recruited for study. All participants scanned using cardiovascular magnetic resonance (CMR) cine underwent native postcontrast T1 mapping obtain left ventricular (LV) function, characteristics. between control compared males females, respectively. For associated with a...
Background.Non-standardized insulin injection has an impact on the efficacy of glucose control.Objectives.The aim study was to explore effectiveness a nursing project in improving self-injection accuracy diabetes mellitus patients. Materials and methods.A total 200 type 2 patients who received therapy with pen were recruited at First Affiliated Hospital Army Medical University (Chongqing, China).Patients randomly assigned control (n = 100) or intervention group.Conventional health education...
Diabetes foot is one of the most serious complications diabetes and an important cause death disability, traditional treatment has poor efficacy there urgent need to develop a practical method.
Impaired skin wound healing is one of the main diabetic complications. However, current treatment strategy limited. Glycerol 3-phosphate dehydrogenase (mGPDH), as a component respiratory chain, plays an important role in cellular bioenergetics. Here, we identified that mGPDH deficiency promotes fibroblast extracellular matrix (ECM) secretion and accelerates healing. Specifically, expression was significantly increased. By contrast, lack promoted migration ECM remodelling. Mechanistically,...
Antithyroid drugs can cause neutropenia or agranulocytosis, rarely pancytopenia in hyperthyroidism therapy. The treatment is difficult and lethality high when granulocytopenia combined with crisis. First Affiliated Hospital of Army Medical University treated a patient who had caused by methimazole systemic lupus erythematosus, secondary crisis agranulocytosis.We gave the reasonable time, such as anti-infection, stimulating granulocyopoiesis, compound iodine solution to control thyroid...
Accurate evaluation of right ventricular (RV) function is always difficult due to its irregular shape and movement. Many indices have been proposed assess RV function, but none universally accepted. This study evaluated in type 2 diabetes mellitus (T2DM) patients using long-axis strain (LAS) other traditional indices.Fifty-seven with T2DM 39 healthy controls were prospectively enrolled. Four-chamber cardiovascular magnetic resonance (CMR) short-axis cine images obtained from all participants...