A5100405809- Pharmacological Effects of Natural Compounds
- Pharmacogenetics and Drug Metabolism
- Plant-based Medicinal Research
- Drug-Induced Hepatotoxicity and Protection
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Analysis
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Hydrogels: synthesis, properties, applications
- Natural product bioactivities and synthesis
- Ocular Surface and Contact Lens
- Antibiotics Pharmacokinetics and Efficacy
- thermodynamics and calorimetric analyses
- Ophthalmology and Visual Impairment Studies
- Immunodeficiency and Autoimmune Disorders
- Liver Diseases and Immunity
- Flavonoids in Medical Research
- Protein purification and stability
- Phytochemical compounds biological activities
- Glaucoma and retinal disorders
- Immunotoxicology and immune responses
- Chromatography in Natural Products
- Nanofluid Flow and Heat Transfer
- Pharmacological Effects and Toxicity Studies
Chongqing Medical University
2013-2024
Chongqing University
2017-2024
Chinese PLA General Hospital
2021-2023
University of Calgary
2009-2022
Third Hospital of Changsha
2022
Xinjiang Agricultural University
2022
National Institutes for Food and Drug Control
2022
Chinese People's Liberation Army
2011-2021
Qilu University of Technology
2021
Shandong Academy of Sciences
2021
Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 highly polymorphic, decreased enzyme has been linked to PQ activity. Despite importance efficacy, exact role that these play pharmacokinetics not extensively studied vivo. In this study, a series pharmacokinetic experiments were conducted with differential characteristics, including wild-type (WT), knockout (KO), humanized...
ABSTRACT Cytochrome P450 (CYP) 2D metabolism is required for the liver-stage antimalarial efficacy of 8-aminoquinoline molecule tafenoquine in mice. This could be problematic Plasmodium vivax radical cure, as human CYP ortholog (2D6) highly polymorphic. Diminished 2D6 enzyme activity, poor-metabolizer phenotype, compromise curative humans. Despite importance efficacy, exact role that plays and pharmacokinetics other molecules has not been extensively studied. In this study, a series...
Thermosensitive hydrogel containing drug-loaded liposomes delivery system offers the possibility of reduced dosing frequency and sustained drug action. In study, a soluble chitosan derivative, N-[(2-hydroxy-3-trimethylammonium) propyl] chloride, was used interacted with glycerophosphate to produce thermosensitive as matrix doxorubicin-loaded liposomes. The formulation could retain liquid state good fluidity below or at room temperature for long time but turn into nonflowing gel after...
To clarify high-risk factors and develop a nomogram model to predict biochemical resolution or nonresolution (BNR) in patients with chronic DILI.
Abstract Background The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, increasing number studies have shown a strong link between abnormal activation pathway, mediated by nucleic acid receptor cGAS, and development progression autoimmune diseases. Therefore, it important to identify effective compound specifically downregulate this for disease. Methods effect Glabridin (Glab) was investigated in BMDMs Peripheral blood mononuclear cell...
The liver-stage anti-malarial activity of primaquine and other 8-aminoquinoline molecules has been linked to bio-activation through CYP 2D6 metabolism. Factors such as poor metabolizer status and/or co-administration drugs that inhibit/interact with could alter the pharmacological properties primaquine. In present study, inhibitory potential selective serotonin reuptake inhibitor (SSRI) norepinephrine (SNRI) classes antidepressants for 2D6-mediated metabolism was assessed using in vitro drug...
In this study, a multi-functional drug delivery system, which combines targeted tumor treatment with glycyrrhetinic acid-modified nanodroplets and ultrasound imaging low-boiling-point phase-change perfluorocarbon, was proposed validated. The obtained were spherical in shape an average size of 324.8 ± 183.7 nm negative zeta-potential. Low-intensity focused (LIFU) introduced to perform US via acoustic droplet vaporization (ADV) both vitro vivo. cytotoxicity cellular uptake studies conducted on...
As one of the most important mosquito‐borne viral diseases, dengue infection is now becoming a global concern due to its rapid spread and rise in incidence. Currently, there no approved vaccine or effective antiviral drug for virus (DENV) infection. Glycyrrhetinic acid (GNa) related derivatives have been reported inhibit broad spectrum viruses. However, it unknown whether Carbenoxolone disodium (CBX), GNa derivatives, affects DENV Here, we found that production infectious particles was...
Context: Da-Huang-Zhe-Chong pill (DHZCP), a classical traditional Chinese formula, consists of 12 crude drugs which have been widely used with significant therapeutic effects. Some in this formula toxicities that might result some adverse effects DHZCP.Objective: The liver protection and toxicity DHZCP were first evaluated against chronic carbon tetrachloride (CCl4)-induced injury rats.Materials methods: rats treated by intraperitoneal injection 10% CCl4 for weeks. At the end week 4, at...
Iron deposition in the brain begins early multiple sclerosis (MS) and continues unabated. Ferrous iron is toxic to neurons, yet therapies used MS do not counter neurotoxicity. Extracts of Hibiscus sabdariffa (HS) are many cultures for medicinal purposes. We collected a distinct HS extract found that it abolished killing neurons by culture; medications were ineffective when similarly tested. Neuroprotection was due chelation or anthocyanin content. In free radical scavenging assays,...
Quality consistency of Glycyrrhiza formula granules is essential for guaranteeing clinical efficacy. However, a suitable method to accurately and conveniently evaluate the efficacy currently not available. This study established simultaneous determination 12 active components in using ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry. The rate inhibition cyclooxygenase-2 by different batches was determined. Near-infrared spectra were...
Objective : To screen all compounds of Agsirga based on the HPLC-Q-Exactive high-resolution mass spectrometry and find potential inhibitors that can respond to 2019-nCoV from active by molecular docking technology. Methods was adopted identify complex components Mongolian medicine Agsirga, separated Q-Exactive detector. Then Orbitrap detector used in tandem spectrometry, related structural formula were found using chemsipider database literature, combined with precise formulas (errors ≤ 5 ×...
<title>Abstract</title> Cerebral endothelial cell dysfunction plays a critical role in the pathophysiology of vascular injury subsequent to subarachnoid hemorrhage (SAH), yet precise molecular mechanism remains largely speculative. Inflammation stands out as pivotal contributor an unfavorable prognosis post-SAH, with nuclear factor-κB (NF-κB) pathways being initiated and ultimately leading inflammation activation pro-inflammatory cytokine release following SAH. In this study, we explored...
ObjectiveThis study aimed to examine the association between controlling nutritional status (CONUT) score and diabetic retinopathy (DR) risk, as well investigate impact of CONUT on mortality risk among DR patients.MethodsThis retrospective included 5,256 patients with diabetes from National Health Nutrition Examination Surveys. These participants were classified into two groups: group (n = 641) non-DR 4,615). We used weighted univariate multivariate logistic regression models assess...