A5008511964- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Surfactants and Colloidal Systems
- Proteoglycans and glycosaminoglycans research
- Supramolecular Chemistry and Complexes
- Liquid Crystal Research Advancements
- Monoclonal and Polyclonal Antibodies Research
- Drug Solubulity and Delivery Systems
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Enzyme Production and Characterization
- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Reactions
- Lanthanide and Transition Metal Complexes
- Metal complexes synthesis and properties
- Nerve injury and regeneration
- Bacteriophages and microbial interactions
- Analytical Chemistry and Chromatography
- Biochemical and Molecular Research
- Synthesis of Organic Compounds
- Organoboron and organosilicon chemistry
- Polyamine Metabolism and Applications
- Crystallography and molecular interactions
- Microfluidic and Capillary Electrophoresis Applications
University of Calgary
2016-2025
Hohai University
2025
Soochow University
2024
Calgary Laboratory Services
2017-2021
Alberta Glycomics Centre
2010-2019
University of Alberta
2000-2009
Fudan University
2006-2007
Centre National de la Recherche Scientifique
1991-1993
Laboratoire de Chimie Organique
1991-1993
Université Paris Cité
1991-1992
Abstract Remyelination is the generation of new myelin sheaths after injury facilitated by processes differentiating oligodendrocyte precursor cells (OPCs). Although this repair phenomenon occurs in lesions multiple sclerosis patients, many fail to completely remyelinate. A number factors have been identified that contribute remyelination failure, including upregulated chondroitin sulfate proteoglycans (CSPGs) comprise part astrogliotic scar. We show vitro , OPCs dramatically reduced process...
Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The deficient repair results from neuroinflammation and deposition inhibitors including chondroitin sulfate proteoglycans (CSPGs). Which CSPG member is repair-inhibitory or alters local inflammation exacerbate injury unknown. Here, we correlate high versican-V1 expression MS lesions with premyelinating oligodendrocytes, highlight its selective upregulation amongst members experimental autoimmune...
Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance
Multiple sclerosis presents with profound changes in the network of molecules involved maintaining central nervous system architecture, extracellular matrix. The matrix components, particularly chondroitin sulfate proteoglycans, have functions beyond structural support including their potential interaction with, and regulation of, inflammatory molecules. To investigate roles proteoglycans multiple sclerosis, we used experimental autoimmune encephalomyelitis model a time course study. We...
When S is SO much better: Conjugate vaccines that contain S-glycosides induce carbohydrate-specific antibodies cross react with the corresponding O-glycosides and vice versa. Four distinct systems have been examined, in each of which antigen-specific response to either comparable or superior O-glycosides.
A new linker system has been designed and applied to neoglycoprotein synthesis. Reaction of oligosaccharide ω-aminoalkyl glycosides with homobifunctional adipic acid p-nitrophenyl diesters in dry DMF gave the corresponding amide half ester good yields sufficient stability permit chromatographic purification. Subsequent conjugation bovine serum albumin under very mild conditions afforded neoglycoproteins efficiency. The method is well suited for coupling small amounts (mg) protein.
Synthetic oligomers of the antigenic<i>Candida albicans</i> (1→2)-β-mannopyranans adopt a compact solution conformation that leads to numerous inter-residue nuclear Overhauser effects, including unprecedented effects between <i>n</i> and + 3 residues. In excellent agreement with experimentally determined distances, unrestrained molecular dynamics point single family conformations approximate helical motif three-residue repeat for this unique homopolymer. When synthetic di- hexasaccharides...
Intracerebral hemorrhage (ICH) causes prominent deposition of extracellular matrix molecules, particularly the chondroitin sulphate proteoglycan (CSPG) member neurocan. In tissue culture, neurocan impedes properties oligodendrocytes. Whether therapeutic reduction promotes oligodendrogenesis and functional recovery in ICH is unknown. Mice were retro-orbitally injected with adeno-associated virus (AAV-CRISPR/Cas9) to reduce after induction by collagenase. Other groups mice treated vehicle or a...
Cement-stabilised macadam (CSM) is widely used in road engineering due to its high strength and durability. Constructing accurate numerical models crucial for analysing failure mechanisms improving the performance service life of CSM. However, accuracy these largely depends on precision mesoscopic parameter inversion. Existing inversion methods mainly rely formula-based derivations manual trial-and-error approaches, which are time-consuming often limited accuracy, typically below 70%. To...
A concise and convenient route that may be easily scaled is reported for the preparation of unprotected β-glucopyranosides N-acetyl-d-glucosamine. Reaction a wide variety alcohols with reactive, readily prepared furanosyl oxazoline under acidic conditions affords corresponding β-d-glucopyranosides in good to high yields. Primary gave only β-d-glucopyranosides. mechanism proposed this transformation.
The furanose acetonide derivative 1 is readily prepared from 2-acetamido-2-deoxy-d-glucose on a large scale without the need for chromatography. Mesylation of provides an efficient, concise, synthetic route to rare 2-acetamido-2-deoxy-β-d-hexopyranosides (2 and 3) via corresponding methyl 2-acetamido-2-deoxy-3-O-methanesulfonyl-β-d-glucopyranoside subsequent inversion configuration by direct displacement or formation 3,4-epoxide. Opening this epoxide azide provided...
Chondroitin sulfate proteoglycans (CSPGs) are upregulated in insults to the central nervous system, including multiple sclerosis (MS), an inflammatory demyelinating condition of system. CSPGs appear be detrimental MS, as they enhance immune responses and act barriers oligodendrocyte differentiation thus remyelination. Despite their deleterious roles, strategies selectively reduce CSPG production lacking. The purpose this study was develop, screen, describe a series glucosamine derivatives...
Novel cyclodextrin (CD)-based amphiphilic poly(carboxylic acid)s that self-assemble into highly ordered smectic liquid crystalline mesophases were investigated as a novel class of protonic conductors. These structurally well-defined materials are synthesized from nontoxic and environment-friendly CDs, which possess unique face-to-face pseudosymmetry. By taking advantage such geometry, series flexible tetraethylene glycol groups terminated with carboxylic acid functionality introduced to the...
Heptakis(6-S-alkyl-6-thio)-cyclomaltoheptaoses (where alkyl is a C2, C4, C10, C16 and C18 unit) have been synthesised via heptakis(6-bromo-6-deoxy)-cyclomaltoheptaose shown to form thermotropic liquid crystals.
Tissue plasminogen activator (tPA) is an essential component of the proteolytic cascade that lyses blood clots. Various studies also suggest tPA plays important roles in nervous system. We show exogenous or tPA/plasminogen (plg) promotes axonal regeneration, remyelination, and functional recovery after sciatic nerve injury mouse. Local application tPA/plg 7 days crush significantly increased total number axons myelinated axons, which accompanied by enhanced expression neurofilament....
A face off: Diisobutylaluminum hydride (DIBAL-H) has been found to be an effective O-desilylating reagent at the primary of cyclodextrins. This methodology shows high chemo- and regioselectivity provides route orthogonally protected, multisubstituted cyclodextrin derivatives.