A5069247523- Congenital heart defects research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- Congenital Heart Disease Studies
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Genomics and Rare Diseases
- Dietary Effects on Health
- Cellular transport and secretion
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Vestibular and auditory disorders
- Connexins and lens biology
- MicroRNA in disease regulation
- RNA regulation and disease
- Birth, Development, and Health
- Lysosomal Storage Disorders Research
- Nutrition, Genetics, and Disease
- Gut microbiota and health
- Circular RNAs in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Cleft Lip and Palate Research
- Immune cells in cancer
- RNA Research and Splicing
Fudan University
2016-2025
Shanghai Medical College of Fudan University
2014-2025
Institute of Biomedical Science
2025
Ningxia Medical University
2025
Children's Hospital of Fudan University
2013-2024
Anhui Science and Technology University
2010
Anhui University of Science and Technology
2010
Eli Lilly (Germany)
2006
Sepsis is regarded as a dysregulated immune response to infections. Recent study showed partially reversal of immunosuppression by trained immunity, which fosters an enhanced towards secondary challenge. However, the role immunity in sepsis has not been fully understood. We profiled characteristics peripheral blood mononuclear cells from septic patients using single-cell RNA sequencing (scRNA-seq) analyses. Murine double-hit models (pretreatment or post-treatment β-glucan mice) and murine...
To explore the approaches and diagnostic yield of genetic testing for renal disease in children, we describe genotype phenotype national cohort children with from 13 different regions China recruited 2014 to 2018 by building up multicenter registration system (Chinese Children Genetic Kidney Disease Database, CCGKDD). diagnosis was confirmed 42.1% our 1001 pediatric patients clinical suspicion a disease. Of 106 distinct monogenetic disorders detected, 15 accounted 60.7% diagnoses. The 29.1%...
As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal cancer. Single-cell RNA...
Abstract Neuroblastoma (NB), an embryonic tumour originating from sympathetic crest cells, is the most common extracranial solid type in children with poor overall prognosis. Accumulating evidence has demonstrated involvement of long non‐coding RNA (lncRNA) numerous biological processes and their associations development multiple diseases. Ectopic lncRNA expression linked to malignant tumours. Previous studies by our team indicate that MEG3 attenuates NB autophagy through inhibition FOXO1...
Abstract To investigate whether and how endothelial cells affect neurogenesis, we established a system to co‐culture brain slices of neonatal rat observed subventricular zone differentiate in the presence cells. In cells, neural stem increased number, as did differentiated neurons glia. The augmentation neurogenesis was reversed by diminishing vascular growth factor (VEGF) expression with RNA interference (RNAi). Microarray analysis indicated that levels 112 genes were significantly altered...
Morphine, a mu-opioid receptor (MOR) agonist, has been extensively used to treat advanced cancer pain. In particular, in patients with metastasis, both morphine and anticancer drugs are given simultaneously. However, evidence showed that might be risk factor promoting the tumor's malignant potential. this study, we report treatment could activate MOR lead promotion of proliferation, migration, invasion HCT116 DLD1 colorectal (CRC) cells time-concentration dependence. Moreover, can also...
Preeclampsia is regarded as an evolution-related disease that has only been observed in humans and our closest relatives, the important factor contributing to its pathogenesis endothelial dysregulation secondary a stressed placenta. Hypoxia-inducible 1 subunit alpha (HIF1α), highly conserved molecule virtually all mammals, crucial regulator of hypoxia adaptation evolution. Persistent high expression HIF1α placenta one pathogenic mechanisms preeclampsia. Therefore, human-specific molecules...
Abstract Congenital heart diseases (CHDs) are the most common types of birth defects, affecting approximately 1% live births and remaining leading cause mortality. CHD patients often show a higher incidence heterotaxy syndrome. However, exact aetiology syndrome remains unclear. In this study, targeted sequencing Sanger were performed to analyze exonic regions 37 primary ciliary dysfunction (PCD)- related candidate genes in 42 with Variants protein-coding filtered according databases known...
Our previous studies demonstrated that MEG3 was significantly downregulated in neuroblastoma (NB) and its expression negatively associated with the INSS stage. Overexpression of promoted apoptosis inhibited proliferation NB cells. In this study, we discovered more potential functions molecular mechanisms NB. According to database, positively correlated survival rate malignant clinical features. Moreover, determined mainly located nucleus by nuclear-cytoplasmic separation RNA fish assays....
Abstract Congenital ptosis, a genetic disorder involving levator palpebrae muscle dysfunction, is often associated with congenital myopathy. The causes of this condition remain poorly understood. In study, we identified FOXK2 mutations in five pedigrees myopathy and ptosis through whole exome sequencing Sanger sequencing. Zebrafish foxk2 deficiency exhibited underdeveloped skeletal muscles reduced mobility, while mice Foxk2 deletion stem cells (MuSCs) showed generalized abnormalities....
Tissue plasminogen activator (tPA) is an essential component of the proteolytic cascade that lyses blood clots. Various studies also suggest tPA plays important roles in nervous system. We show exogenous or tPA/plasminogen (plg) promotes axonal regeneration, remyelination, and functional recovery after sciatic nerve injury mouse. Local application tPA/plg 7 days crush significantly increased total number axons myelinated axons, which accompanied by enhanced expression neurofilament....
Objective . To investigate the joint effects of single nucleotide polymorphisms (SNPs) genes in folic acid pathway on homocysteine (Hcy) metabolism. Methods Four hundred women with normal pregnancies were enrolled this study. SNPs identified by MassARRAY. Serum and Hcy concentration measured. Analysis variance (ANOVA) support vector machine (SVM) regressions used to analyze level. Results MTHFR (rs1801133 rs3733965) significantly associated maternal serum In different genotypes (rs1801133),...
Objective: We aimed to study the impacts of pre-eclampsia on cognitive and learning capabilities adolescent rat offspring explore possible underlying mechanisms at molecular level. Methods: Pregnant rats were subcutaneously injected with saline solution (control) (n = 16) or NG-nitro-L-arginine methyl ester (L-NAME) from 13th day gestation until parturition. The brain tissues fetal delivered by cesarean section examined in both groups hematoxylin eosin (H&E) staining. Rats born vaginally...
Neuroblastoma (NB) is the most common type of extracranial solid tumor found in children. Despite several treatment options, patients with advanced stage disease have a poor prognosis. Previous studies reported that enhancer zeste homolog 2 (EZH2) and long non-coding RNAs (lncRNAs) abnormal expression levels NB participate tumorigenesis development. However, association between EZH2 lncRNAs remain unclear. In present study, RNA immunoprecipitation-sequencing (RIP-seq) was used to analyze...
Background Nephronophthisis-related ciliopathies (NPHP-RC) account for the majority of cases monogenetically caused end-stage renal disease (ESRD) in children. Exploring correlation between phenotype and genotype NPHP-RC is helpful early diagnosis management. We investigated spectra a Chinese multicentre cohort. Methods Crosss-ectional longitudinal data 60 patients from 57 families with pathogenic gene mutations distributed 22 regions China were collected into unified, anonymous database....
Ferroptosis is a unique modality of regulated cell death that driven by iron-dependent phospholipid peroxidation. N6-methyladenosine (m
Congenital orofacial cleft, the most common birth defect in maxillofacial region, exhibits a wide range of prognosis depending on severity deformity and underlying etiology. Non-syndromic congenital clefts typically present with milder deformities more favorable treatment outcomes, whereas syndromic often manifest concomitant organ abnormalities, which pose greater challenges for result poorer prognosis. This consensus provides an elaborate classification system varying degrees along...