A5006064109- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Essential Oils and Antimicrobial Activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Crystallization and Solubility Studies
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Piperaceae Chemical and Biological Studies
- Curcumin's Biomedical Applications
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- COVID-19 Clinical Research Studies
- Medicinal Plants and Neuroprotection
- Pharmaceutical studies and practices
- Natural Fiber Reinforced Composites
- Multiple Sclerosis Research Studies
- Pharmaceutical Economics and Policy
- Alzheimer's disease research and treatments
- Immune Response and Inflammation
- Biotechnology and Related Fields
Maharshi Dayanand University
2015-2025
Memorial University of Newfoundland
2021-2024
Indian Institute of Technology Roorkee
2022-2024
Health Sciences Centre
2024
University of Calgary
2015-2022
University of Nizwa
2022
University of Petroleum
2022
Prince Sattam Bin Abdulaziz University
2022
Qassim University
2022
Chitkara University
2022
Nanotechnology is indisputably a scientific technique that offers the prospect of new therapies, and hope, for treatment malignant illnesses. It novel technology approaches diagnosis management diverse diseases. Although discovery Quantum dots (QD) nano-transporters has already led to few positive developments, QD are still at their initial stage, though have yet proven valuable society. The excertion indicates conversion in natural imaging along with photograph established incredible...
Background Japanese Encephalitis virus (JEV) is a common cause of acute and epidemic viral encephalitis. JEV infection associated with microglial activation resulting in the production pro-inflammatory cytokines including Interleukin-1 β (IL-1β) Interleukin-18 (IL-18). The Pattern Recognition Receptors (PRRs) underlying mechanism by which microglia identify particle leading to these unknown. Methodology/Principal Findings For our studies, we have used murine model as well BV-2 mouse cell...
ABSTRACT MicroRNAs (miRNAs) are single-stranded small RNA molecules that regulate various cellular processes. miRNA 155 (miR-155) regulates aspects of innate and adaptive immune responses plays a key role in viral infections the resulting neuroinflammation. The present study evaluated involvement miR-155 modulating Japanese encephalitis virus (JEV)-induced We observed expression was upregulated during JEV infection mouse primary microglia, BV-2 microglia cell line, both human brains. In...
Abstract Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population extrinsic factors lesion microenvironment of older subjects contribute to this decline. Microglia monocyte-derived macrophages are critical for successful remyelination, releasing growth clearing inhibitory myelin debris. Several studies have implicated delayed...
The migration of leukocytes into the CNS drives neuropathology multiple sclerosis (MS). This penetration likely utilizes energy resources that remain to be defined. Using experimental autoimmune encephalomyelitis (EAE) model MS, we determined macrophages within perivascular cuff post-capillary venules are highly glycolytic as manifested by strong expression lactate dehydrogenase A (LDHA) converts pyruvate lactate. These expressed prominent levels monocarboxylate transporter-4 (MCT-4)...
Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The deficient repair results from neuroinflammation and deposition inhibitors including chondroitin sulfate proteoglycans (CSPGs). Which CSPG member is repair-inhibitory or alters local inflammation exacerbate injury unknown. Here, we correlate high versican-V1 expression MS lesions with premyelinating oligodendrocytes, highlight its selective upregulation amongst members experimental autoimmune...
The use of cosmeceuticals has drastically risen in recent years. This significantly increases the armamentarium clinician improving treatment skin, hair, and other conditions. They are at juncture where wellness meets beauty growing by consumers is indicative their popularity. article focuses on regulatory aspects.<br>
Abstract Background Activation of microglia, the resident macrophages central nervous system (CNS), is hallmark neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection. The activation microglia often bystander neuronal death. Nuclear factor-κB (NF-κB) one important transcription factors known to be microglial which upregulates expression inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (Cox-2) pro-inflammatory cytokines. Recent...
Japanese encephalitis virus (JEV), a single-stranded RNA (ssRNA) virus, is the leading cause of in Asia. Microglial activation one key events JEV-induced neuroinflammation. Although various microRNAs (miRNAs) has been shown to regulate microglia during pathological conditions including neuroviral infections, till date, involvement miRNAs JEV infection not evaluated. Hence, we sought evaluate possible role mediating activation. Initial screening revealed significant up-regulation miR-29b...
Purpose: The purpose of this proposed research was to investigate a nano-formulation developed using self-nanoemulsifying drug delivery system (SNEDDS) improve the pharmacodynamic potential rosuvastatin by assisting its transportation through lymphatic circulation. Methods: utilized lipids, surfactants, and co-surfactants for SNEDDS were selected on basis solubility studies. formulation optimized implementing D-optimal mixture design, wherein effect concentration Capmul MCM EP (X 1 ), Tween...
Alzheimer's disease (AD) is a neurodegenerative that affects wide range of populations and the primary cause death in various countries. The treatment AD still restricted to oral conventional medicines act only superficially. Fabrication intranasal solid lipid nanoparticulate system for uptake therapeutic agents will as convincing approach with limited off-site toxicity increased pharmacological activity. objective this study was formulate, optimize, evaluate efficiency rivastigmine tartrate...
In the past, curcumin was go-to medication for diabetes, but recent studies have shown that tetrahydrocurcumin is more effective. The problem it's not very soluble in water or bioavailable. So, our research aims to increase bioavailability and anti-diabetic efficacy of streptozotocin-induced diabetic rats by synthesizing tetrahydrocurcumin-loaded solid lipid nanoparticles. Box Behnken Design employed optimization nanoparticles (THC-SLNs). optimal formulation determined doing an ANOVA examine...