A5045837608- Advancements in Transdermal Drug Delivery
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Pharmacological Effects of Medicinal Plants
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Dendrimers and Hyperbranched Polymers
- Protein Hydrolysis and Bioactive Peptides
- Parathyroid Disorders and Treatments
- Nanotechnology research and applications
- Analytical Methods in Pharmaceuticals
- Nanoparticles: synthesis and applications
- Seaweed-derived Bioactive Compounds
- Neonatal Health and Biochemistry
- Genetic Syndromes and Imprinting
- Retinoids in leukemia and cellular processes
Maharishi Markandeshwar University, Mullana
2019-2024
In the past, curcumin was go-to medication for diabetes, but recent studies have shown that tetrahydrocurcumin is more effective. The problem it's not very soluble in water or bioavailable. So, our research aims to increase bioavailability and anti-diabetic efficacy of streptozotocin-induced diabetic rats by synthesizing tetrahydrocurcumin-loaded solid lipid nanoparticles. Box Behnken Design employed optimization nanoparticles (THC-SLNs). optimal formulation determined doing an ANOVA examine...
Nanoparticle-based drug delivery systems represent a transformative advancement in targeted therapeutics, providing meticulous delivery, enhanced bioavailability, and diminished side effects. However, designing nanoparticles (NPs) optimal for specific drugs diseases remains complex challenge. The advancements artificial intelligence (AI) have provided innovative approaches to design optimize these systems, improving their efficacy adaptability. This review encompasses the integration of AI...
Amaç: Bu çalışmada, febukostatın (FEB) oral biyoyararlanımını iyileştirmek için nano yapılı lipit taşıyıcıların (NLC) geliştirilmesi amaçlanmıştır.Gereç ve Yöntemler: Sıvı olarak oleik asit katı stearik kullanarak FEB yüklü NLC'leri hazırlamak amacıyla iyi bilinen bir teknik olan yüksek hızlı homojenizasyon ardından, modifiye edilmiş su banyosu sonikasyonu kullanıldı.X1 (sıvı/katı oranı) X2 (yüzey aktif madde konsantrasyonu) olmak üzere iki bağımsız değişkenin Y1 (partikül boyutu) Y2 (%
Oral administration of drugs having low water solubility is hampered by various enzymatic barriers present in gastrointestinal (GI) tract.Lipid nanoparticles based on solid matrix have emerged as a potential drug delivery system to improve the absorption and bioavailability several drugs, especially lipophilic compounds.Solid lipid (SLN) are reported most promising technology for oral offered advantages over conventional dosages formulations including, enhancement solubility, stability,...
A new and simple technique of RP-HPLC was developed validated for the estimation Teneligliptin in tablet dosage form. The partition or separation accomplished on Kromasil C18 analytical column (150 mm × 4.6 mm, 5.0 μm) utilizing acetonitrile, water trifluoroacetic acid as mobile phase acetonitrile B at a flow rate 1.0 ml/min. detector used present study UV detection detected 245nm. total chromatographic analysis time per sample about 55.0 min with teneligliptin eluting retention 11.2...
Due to poor bioavailability and chemical instability, the effectiveness of curcumin is negligible in treatment numerous diseases. Solid lipid nanoparticles (SLNs) increase lipophilic compounds protect drug from gastrointestinal degradation. The objective our study utilization SLNs improve pharmacokinetics pharmacodynamics management diabetes mellitus. Central composite design was used prepare curcumin-loaded (Cur-SLN). analysis independent variables like concentration, surfactant...
Abstract Background Curcumin is a polyphenolic compound with numerous therapeutic activities. There no validated method available for the quantitative estimation of curcumin in simulated nasal fluid. Objective The aim present investigation was to develop simple and precise UV visible spectrophotometric pure form Method Suitable solvent system selected by at maxima 421nm fluid two surfactants (tween 80 sodium lauryl sulphate). double beam spectrophotometer used measurement absorption. further...
Background: Due to solubility issues of curcumin and tetrahydrocurcumin, there is a need for the development UV-Visible spectrophotometric method that can estimate drug release precisely accurately. The addition surfactant in dissolution medium low concentration achieved bio-comparable surface activity be used from formulations by avoiding sink conditions. Objective: purpose present investigation was develop simple précise determination tetrahydrocurcumin after oral administration. Method: A...
Introduction: Solid Lipid nanoparticles (SLN) are comprising of a solid lipid core with mean diameter between 50 and 1000 nm. SLN is an advanced carrier system to traditional colloidal carriers such as emulsion, liposomes, polymeric microparticles. Objective: The objective this study was formulate Itraconazole (ITZ) for intranasal administration. Methods: ITZ-loaded were prepared by high pressure homogenization technique using the Central Composite Design (CCD). concentration surfactant (X1)...
Background: The potential use of nanocarriers is being explored rapidly for the targeted delivery anticancer agents. Curcumin a natural polyphenolic compound obtained from rhizomes turmeric, belongs to family Zingiberaceae. It possesses chemopreventive and chemotherapeutic activity with low toxicity in almost all types cancer. solubility bioavailability curcumin make it unable clinical purpose. necessity an effective strategy overcome limitations responsible development its nanocarriers....
Background: Curcumin shows degradation in the solution of high pH. There is a need for development method which can estimate drug release precisely and accurately. The UV spectroscopy due to its simplicity specificity most popular determination drugs. Objective: present study was aimed develop UV-Visible spectrophotometric assessment curcumin tetrahydrocurcumin (THC) using stable solvent system. Method: solubility determined at various physiological pH levels. Non-ionic surfactant, tween 80...
Background: Drugs having high first-pass metabolism or that are susceptible to enzymatic degradation can be administered through the nasal route avoid their degradation. Lurasidone exhibits less toxicity and side effects as compared its sister drugs like risperidone, ziprasidone, clozapine, etc. Objectives: The present study aimed develop loaded niosomes for delivery. Methods: were developed by adapting ether injection method optimized using a central composite design. In vitro in vivo...
Aims: To prepare curcumin loaded solid lipid nanoparticles for nasal administration using Box-Behnken design. Background: The effectiveness of in neurological disorders is widely studied by various researchers, but its use limited due to poor bioavailability. brain-targeting efficiency can be improved via administration. Objective: In the present work, Curcumin (CUR-SLN) were formulated and optimized Methods: Based on solubility studies, cetostearyl alcohol poloxamer 407 selected as...
In the present study solid lipid nanoparticles (SLNs) of simvastatin were formulated using glyceryl monostearate and stearic acid in ratio 1:1 by applying 32 factorial design. The SLNs optimized to check effect melted surfactant concentration on particle size entrapment efficiency. A total 12 formulations prepared characterization parameters studied. formulation was selected studying interaction between factors polynomial equations 3D response plots. Particle percentage efficiency found...