A5038473837- Neuroinflammation and Neurodegeneration Mechanisms
- Proteoglycans and glycosaminoglycans research
- Biochemical effects in animals
- Protein Hydrolysis and Bioactive Peptides
- Immune cells in cancer
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Meat and Animal Product Quality
- Multiple Sclerosis Research Studies
- Inflammation biomarkers and pathways
- Fibroblast Growth Factor Research
- Neonatal Respiratory Health Research
- Neurological Disease Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and biosynthesis
- Echinoderm biology and ecology
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Glutathione Transferases and Polymorphisms
University of Calgary
2018-2024
University of Saskatchewan
2023-2024
Dalian Polytechnic University
2018-2023
Second Affiliated Hospital of Nanchang University
2019-2023
Nanchang University
2019-2023
Ontario Brain Institute
2021
University of British Columbia
2012-2020
Yanan University Affiliated Hospital
2016
BC Cancer Agency
2014-2016
Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response injury; however, similarities between these cells make it challenging distinguish their relative contributions. We genetically labeled microglia CNS-associated them from macrophages. Using single-cell RNA sequencing, we describe multiple activation states, one of which was enriched for interferon associated signaling. Although blood-derived acutely infiltrated demyelinated lesion,...
Abstract Mesolimbic dopamine (DA) signaling has been implicated in the incentive, reinforcing and motivational aspects of food intake. Insulin receptors are expressed on dopaminergic neurons ventral tegmental area (VTA), insulin may act VTA to suppress feeding. However, neural mechanisms underlying effects poorly understood. Here, we measured evoked DA concentration using fast‐scan cyclic voltammetry. concentration‐dependently reduced somatodendritic VTA, requiring activation phosphoinositol...
Significance Our study reveals lineage-specific mechanisms of ROS control and associated sensitivity to oxidative DNA damage in the basal luminal progenitor-enriched subsets normal human mammary cells. We show that primitive cells contain more mitochondria, greater uptake O 2 , sustain withstand higher levels ROS, have allow them accrue mutagenic damage. These findings support a growing body data suggesting involvement generation breast cancers.
Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The deficient repair results from neuroinflammation and deposition inhibitors including chondroitin sulfate proteoglycans (CSPGs). Which CSPG member is repair-inhibitory or alters local inflammation exacerbate injury unknown. Here, we correlate high versican-V1 expression MS lesions with premyelinating oligodendrocytes, highlight its selective upregulation amongst members experimental autoimmune...
Aging is a significant risk factor associated with the progression of CNS neurodegenerative diseases including multiple sclerosis (MS). Microglia, resident macrophages parenchyma, are major population immune cells that accumulate in MS lesions. While they normally regulate tissue homeostasis and facilitate clearance neurotoxic molecules oxidized phosphatidylcholines (OxPCs), their transcriptome neuroprotective functions reprogrammed by aging. Thus, determining factors instigate aging...
Abstract The extracellular matrix glycosaminoglycan, hyaluronan, has been described as a regulator of tissue inflammation, with hyaluronan fragments reported to stimulate innate immune cells. High molecular mass is normally present in tissues, but upon inflammation lower are generated. It unclear if these induce an inflammatory response or consequence inflammation. In this study, mouse bone marrow derived macrophages and dendritic cells (DCs) were stimulated various sizes from different...
Background Inflammation-exacerbated secondary brain injury and limited tissue regeneration are barriers to favourable prognosis after intracerebral haemorrhage (ICH). As a regulator of inflammation lipid metabolism, Liver X receptor (LXR) has the potential alter microglia/macrophage (M/M) phenotype, assist repair by promoting cholesterol efflux recycling from phagocytes. To support clinical translation, benefits enhanced LXR signalling examined in experimental ICH. Methods...
The flavor fingerprint of sea cucumbers was developed and volatile compounds were investigated by HS-GC-IMS. A total 73 typical target identified. differences in from different seasonings soaking samples areas observed. After soaking, the concentration such as 1-octen-3-one 3-methyl-2-butanol decreased, while representative β-ocimene, linalool furaneol increased. Subsequently, PCA performed based on signal intensity identified compounds, results clearly showed that without group...
Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles immunosurveillance and lipid surfactant catabolism. AMs lacking unable to bind glycosaminoglycan, hyaluronan, which compromises their survival leads reduced numbers of lung. Using RNA sequencing, lipidomics multiparameter flow cytometry, we demonstrate CD44-/- mice have impaired AM increased lipids had expression CD36, a scavenger receptor, as...
Impairment of oligodendrocytes and myelin contributes to neurological disorders including multiple sclerosis (MS), stroke Alzheimer's disease. Regeneration (remyelination) decreases the vulnerability demyelinated axons, but this repair process commonly fails with disease progression. A contributor inefficient remyelination is altered extracellular matrix (ECM) in lesions that remains be better defined. We have identified fibulin-2 (FBLN2) as a highly upregulated ECM component MS stroke,...
The aim of the study was to evaluate neuroprotective function sea cucumber ovum peptide-derived NDEELNK and explore underlying molecular mechanisms. exerted effect by improving acetylcholine (ACh) level reducing acetylcholinesterase (AChE) activity in PC12 cells. By docking, we confirmed that backbone AChE interacted through hydrophobic hydrogen bonds contact with amino acid residues cavity wall. increased superoxide dismutase (SOD) decreased reactive oxygen species (ROS) production, thereby...
Neuroinflammation and neurodegeneration are key processes that mediate the development progression of neurological diseases. However, mechanisms modulating these in different diseases remain incompletely understood. Advances single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 is associated with neuroinflammation central nervous system (CNS). encodes galectin-3 (Gal3), a β-galactoside glycan binding glycoprotein frequently upregulated by...
Abstract Oxidative stress promotes tissue injury in the central nervous system neurological disorders such as multiple sclerosis (MS). To protect against this, antioxidant enzymes including superoxide dismutase-1 (SOD1), heme oxygenase-1 (HO-1), peroxiredoxin-5 (PRDX5) and glutathione peroxidase-4 (GPX4) may be upregulated. However, whether enzyme elevation mouse models of neurodegeneration corresponds to their expression human diseases MS requires investigation. Here, we analyzed compared...