A5102924059- Transcranial Magnetic Stimulation Studies
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Inflammation biomarkers and pathways
- Children's Physical and Motor Development
- Adipose Tissue and Metabolism
- Physical Activity and Health
- Stroke Rehabilitation and Recovery
- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Impact of Technology on Adolescents
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Sports Performance and Training
- Lower Extremity Biomechanics and Pathologies
University of Alberta
2020-2023
Women and Children’s Health Research Institute
2020-2023
Northeastern University
2023
Brigham Young University
2017
Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response injury; however, similarities between these cells make it challenging distinguish their relative contributions. We genetically labeled microglia CNS-associated them from macrophages. Using single-cell RNA sequencing, we describe multiple activation states, one of which was enriched for interferon associated signaling. Although blood-derived acutely infiltrated demyelinated lesion,...
Experienced runners appear to naturally select a stride length which is optimal for minimizing oxygen uptake. However, whether this ability built into the human body or it learned through experience has not been previously tested. This study investigated inexperienced are as capable experienced of self-optimizing minimize Thirty-three subjects (nineteen and fourteen inexperienced) ran twenty-minutes while preferred economical lengths were measured. A t-test checked differences between groups...
Objective Intervention research using digital games to promote physical activity has proliferated. Yet few studies have attempted systematically catalog features that characterize this research. To address gap, we undertook a systematic review and content analysis of active video game interventions, examining only published longitudinal interventions prominently featured technology (≥50% the intervention). Methods Our protocol was registered in International Prospective Register Systematic...
Dysregulation of the C5a-C5a receptor 1 (C5aR1) signalling axis underlies inflammation and immune-driven pathology. C5aR1 was traditionally thought to be primarily expressed on cell membrane, although recent reports indicate importance intracellular expression for inflammatory effector functions various types. However, mechanisms regulating localisation remain unclear. In tumours with an immunosuppressive microenvironment, we recently found robust malignant epithelial cells, highlighting...
Abstract Recent successes with cell therapies, including CAR-T and CAR-NK cells, for hematopoietic cancers have yet to translate into solid tumors. The major obstacle tumors present therapy is the highly immunosuppressive tumor microenvironment (TME), which can impair function of endogenous as well therapeutic immune cells. To overcome this challenge, Senti Bio developing gene circuits arm cells multiple cytokines improve cytotoxicity persistence product candidates. Cytokines, other...
Monday, April 27April 14, 2020Free AccessTelerehabilitation for Neurological Disability with Remotely Supervised Transcranial Direct Current Stimulation (RS-tDCS) (1568)Kelly Lee, Amy Ro, Matthew Lustberg, Michael Shaw, Nabil Khan, Pamela Best, Martin Malik, … Show All , Jon Links, Allan George, Abhishek Datta, Marom Bikson, Kathleen Sherman, Lauren Krupp, and Leigh Charvet FewerAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.1568...