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A5014862004
Research Areas
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Immune cells in cancer
University of Calgary
2020
Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response injury; however, similarities between these cells make it challenging distinguish their relative contributions. We genetically labeled microglia CNS-associated them from macrophages. Using single-cell RNA sequencing, we describe multiple activation states, one of which was enriched for interferon associated signaling. Although blood-derived acutely infiltrated demyelinated lesion,...
10.1126/sciadv.aay6324
article
EN
cc-by-nc
Science Advances
2020-01-16
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