A5065696778- Pain Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Exercise and Physiological Responses
- Inflammation biomarkers and pathways
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Acupuncture Treatment Research Studies
- Nicotinic Acetylcholine Receptors Study
- Vagus Nerve Stimulation Research
- Immune cells in cancer
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Olfactory and Sensory Function Studies
- Botulinum Toxin and Related Neurological Disorders
University of Alberta
2016-2020
Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response injury; however, similarities between these cells make it challenging distinguish their relative contributions. We genetically labeled microglia CNS-associated them from macrophages. Using single-cell RNA sequencing, we describe multiple activation states, one of which was enriched for interferon associated signaling. Although blood-derived acutely infiltrated demyelinated lesion,...
Trigeminal neuropathic pain is a well-recognized complication of the demyelinating disease multiple sclerosis (MS). However, mechanisms underlying MS-related trigeminal are poorly understood. This can be attributed, at least in part, to lack an animal model that exhibits pathology similar described MS. Experimental autoimmune encephalomyelitis (EAE) commonly used study pathophysiology We show here mice with EAE exhibit increased sensitivity air puffs applied whisker pad. The puff stimulation...
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) stress in dorsal root ganglia (DRG) contributes to hypersensitivity the experimental autoimmune encephalomyelitis (EAE) mouse model MS. Inflammatory cells increased levels ER markers evident post-mortem DRGs from MS patients. Similarly, observed DRG mice with EAE relieving chemical chaperone, 4-phenylbutyric acid...
Multiple sclerosis (MS) is an inflammatory, neurodegenerative autoimmune disease associated with sensory and motor dysfunction. Although estimates vary, ∼50% of patients MS experience pain during their disease. The mechanisms underlying the development are not fully understood, no effective treatment for MS-related available. Previous work from our laboratory demonstrated that voluntary exercise (wheel running) can reduce nociceptive behaviours at onset in female mice experimental...
ABSTRACT Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) stress in dorsal root ganglia (DRG) contributes to hypersensitivity the experimental autoimmune encephalomyelitis (EAE) mouse model MS. Inflammatory cells increased levels ER markers evident post-mortem DRGs from MS patients. Similarly, observed DRG mice with EAE relieving chemical chaperone, 4-phenylbutyric...