Saqer S. Alotaibi

ORCID: 0000-0002-6162-7953
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About
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Research Areas
  • Crop Yield and Soil Fertility
  • Entomopathogenic Microorganisms in Pest Control
  • Nematode management and characterization studies
  • Drug-Induced Hepatotoxicity and Protection
  • Insect Resistance and Genetics
  • Photosynthetic Processes and Mechanisms
  • Insect Pest Control Strategies
  • Plant biochemistry and biosynthesis
  • Moringa oleifera research and applications
  • Soil Carbon and Nitrogen Dynamics
  • Plant Molecular Biology Research
  • Biodiesel Production and Applications
  • Plant tissue culture and regeneration
  • Essential Oils and Antimicrobial Activity
  • Plant Micronutrient Interactions and Effects
  • Nanoparticles: synthesis and applications
  • Plant Pathogens and Fungal Diseases
  • Chemotherapy-induced organ toxicity mitigation
  • Phytochemicals and Antioxidant Activities
  • Insect-Plant Interactions and Control
  • Potato Plant Research
  • Insect symbiosis and bacterial influences
  • Ethnobotanical and Medicinal Plants Studies
  • Rice Cultivation and Yield Improvement
  • Heavy metals in environment

Taif University
2018-2025

King Abdulaziz Medical City
2024

University of Manchester
2023

Alexandria University
2021

Kafrelsheikh University
2021

Taibah University
2021

University of Sadat City
2021

Cairo University
2021

Assiut University
2019

University of Essex
2017-2018

To meet the growing demand for food, substantial improvements in yields are needed. This is particularly case wheat, where global yield has stagnated recent years. Increasing photosynthesis been identified as a primary target to achieve improvements. increase leaf level of Calvin–Benson cycle enzyme sedoheptulose-1,7-biphosphatase (SBPase) increased through transformation and expression Brachypodium distachyon SBPase gene construct. Transgenic lines with protein levels activity were grown...

10.1098/rstb.2016.0384 article EN cc-by Philosophical Transactions of the Royal Society B Biological Sciences 2017-08-14

Salinity stress is one of the most prominent abiotic stresses that negatively affect crop production. Transcription factors (TFs) are involved in absorption, transport, or compartmentation sodium (Na+) potassium (K+) to resist salt stress. The basic helix–loop–helix (bHLH) a TF gene family critical for plant growth and responses, including salinity. Herein, we used CRISPR/Cas9 strategy generate editing mutant investigate role OsbHLH024 rice under A nucleotide base deletion was identified...

10.3390/plants11091184 article EN cc-by Plants 2022-04-27

The Acrylamide is a toxic compound generated under oxidative stress arising from intracellular ROS production and induced toxicity. It frequently used in industry through the heating of tobacco foods high carbohydrates. exact mechanism its toxicity still unclear. In this study, an extract peels pomegranate (Punica granatum L.), nutritious visually appealing fruit with diverse bioactive profile, was examined for potential anti-apoptotic, antioxidant, anti-inflammatory effects. A total 40...

10.3390/life12020224 article EN cc-by Life 2022-01-31

Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the treatment of different types cancers management chronic inflammatory diseases. However, its use is associated with hepatotoxicity. Vitamin C (VC) curcumin (CUR) exhibit anti-inflammatory antioxidant effects. Thus, we aimed to investigate potential hepatoprotective effects VC CUR pretreatment alone combination against MTX-induced Albino mice were randomly divided into 7 groups: control group, which received...

10.3389/fmed.2022.866343 article EN cc-by Frontiers in Medicine 2022-04-14

The inhibitory potential of Artemisia annua, a well-known antimalarial herb, against several viruses, including the coronavirus, is increasingly gaining recognition. plant extract has shown significant activity both Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and novel SARS-CoV-2 that currently ravaging world. It therefore necessary to evaluate individual chemicals for purpose designing drugs treatment COVID-19. In this study, we employed computational techniques comprising...

10.3389/fmed.2022.907583 article EN cc-by Frontiers in Medicine 2022-06-15

Nanoparticles (NPs), due to their tailored properties, serve as potential sources of nutrients for the biofortification edible grains. Chickpeas are a valued legume crop, widely consumed in developing countries. Thus, improve Zn and Fe content chickpeas, two-year study was conducted examine foliar application mineral (0.5% Fe), chelated (0.3% Fe) nanoforms ZFN) fertilizers enhance chickpea. The 0.5% ZnO NPs + Fe2O3 (ZFN) at pre-flowering stage showed highest increase grain yield, uptake...

10.3390/agronomy11122436 article EN cc-by Agronomy 2021-11-29

Accumulation of heavy metals (HMs) by ornamental plants (OPs) from contaminated agriculture soils is a unique technique that can efficiently reduce the metal load in food chain. Amaranthus tricolor L. has attractive characteristics acquiring higher growth rate and large biomass when grown at soils. Site-specific detailed information not available on use A. plant phytoremediation polluted sites. The study aimed to enhance uptake HMs (Pb, Zn, Cu) via amending poultry litter extract (PLE),...

10.3390/molecules26113360 article EN cc-by Molecules 2021-06-02

Plant cell growth responds rapidly to various stimuli, adapting architecture environmental changes. Two major endogenous signals regulating are the phytohormone auxin and secreted peptides rapid alkalinization factors (RALFs). Both trigger very cellular responses also exert long-term effects [Du et al., Annu. Rev. Biol. 71, 379–402 (2020); Blackburn Physiol. 182, 1657–1666 (2020)]. However, way, in which these distinct signaling pathways converge regulate growth, remains unknown. Here, using...

10.1073/pnas.2121058119 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2022-07-25

The potato is one of the most important and valuable crops in terms consumption worldwide. However, abiotic stressors are critical delimiters for growth productivity potato. Invertase genes play key roles carbon metabolism, plant development, responses to stress stimuli. Therefore, a comprehensive genome-wide identification, characterization expression analysis invertase was performed current study identified 19 genes, randomly distributed throughout genome. To further elucidate their...

10.3390/biology11040539 article EN cc-by Biology 2022-03-31

Alzheimer's disease (AD) is a neurodegenerative that affects wide range of populations and the primary cause death in various countries. The treatment AD still restricted to oral conventional medicines act only superficially. Fabrication intranasal solid lipid nanoparticulate system for uptake therapeutic agents will as convincing approach with limited off-site toxicity increased pharmacological activity. objective this study was formulate, optimize, evaluate efficiency rivastigmine tartrate...

10.3389/fnagi.2022.960246 article EN cc-by Frontiers in Aging Neuroscience 2022-08-11

Mutations in GDAP1 (Ganglioside-induced differentiation-associated protein 1) gene are linked to Charcot-Marie-Tooth disease (CMT), a Heterogenous group of disorders with multiple phenotypes, characterized by peripheral nerve dysfunction that can lead vocal cord paralysis and diaphragmatic dysfunction.All three affected children this chosen family have manifested the same clinical symptoms progressive weakness, mild sensory impairment, absent tendon reflexes their early years....

10.1186/s43141-023-00568-9 article EN cc-by Journal of Genetic Engineering and Biotechnology 2023-11-15

Global crop production is significantly reduced by rapid changes in the climate, either natural or manmade activities. The frequent application of various fertilizers, has resulted soil pollution, which further exacerbated water scarcity. indiscriminate use chemical fertilizers led to devastating consequences such as reduction fertility, environmental contamination, increased insect resistance, destroyed biodiversity, and ultimately heavy economic losses. Another approach being investigated...

10.1016/j.indic.2024.100470 article EN cc-by-nc Environmental and Sustainability Indicators 2024-08-31

Nitrogen application rates and plant density are vital factors that influence cotton production considerably. The aim of the experiment was to study effect varied nitrogen (N) rate planting densities (PD) on growth yield performance two cultivars from different origins. research laid out in Randomized Complete Block Design (RCBD) with split plot arrangements. There were levels; low N level (F1 120 kg ha−1) high (F2 180 three densities; 8 plants m−2 as (LPD), 10 medium (MPD) 12 (HPD). During...

10.1016/j.jksus.2021.101512 article EN cc-by-nc-nd Journal of King Saud University - Science 2021-06-06

Abstract Acrylamide (A) is known for its biological toxicity and S. imbricata recognized various activities. The leaf extract of was utilized as a protective approach from acrylamide-induced oxidative stress at the transcriptome level by analyzing global gene expression, processes pathways. Three groups rats were used to investigate effect on liver transcriptome: Group C (Control), group A (received acrylamide), A_S acrylamide extract). Transcriptome analysis conducted using RNAseq with...

10.1093/toxres/tfaf038 article EN Toxicology Research 2025-03-01
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