A5023823204- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Proteoglycans and glycosaminoglycans research
- Peripheral Neuropathies and Disorders
- Cerebrospinal fluid and hydrocephalus
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Stress Responses and Cortisol
- Electrolyte and hormonal disorders
- Long-Term Effects of COVID-19
- Atherosclerosis and Cardiovascular Diseases
- Fetal and Pediatric Neurological Disorders
- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
- Asthma and respiratory diseases
- Mitochondrial Function and Pathology
- Cytokine Signaling Pathways and Interactions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Connective tissue disorders research
- interferon and immune responses
- Cerebrovascular and genetic disorders
- Nerve injury and regeneration
University of Calgary
2025
University of Southern Denmark
2014-2021
Institute for Molecular Medicine Finland
2019
Owens Community College
2015-2016
The Type I interferons (IFN), beta (IFN-β) and the alpha family (IFN-α), act through a common receptor have anti-inflammatory effects. IFN-β is used to treat multiple sclerosis (MS) effective against experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Mice with EAE show elevated levels of IFNs in central nervous system (CNS), suggesting role endogenous IFN during inflammation. However, therapeutic benefit produced CNS remains be established. aim this study was examine...
To clarify the significance of immunoglobulin G autoantibody specific for astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin from a neuromyelitis optica patient was administered intrathecally to naïve mice, and distribution pathogenic impact evaluated. A distinct pattern deposition observed subarachnoid subpial spaces where vessels penetrate brain parenchyma, via paravascular route with intraparenchymal perivascular deposition. Perivascular...
Encounter of autoantibodies with specific antigens can lead to hypersensitivity reactions and pathology. In multiple sclerosis neuromyelitis optica spectrum disease (NMOSD), immunoglobulin-G (IgG) deposition has been observed in pathological lesions the central nervous system. The paradigmatic NMOSD are for water channel aquaporin-4, localized astrocytic end-feet at blood-brain barrier ependymal cells cerebrospinal fluid-brain barrier. We have previously that IgG antibodies from NMO patients...
The pathological hallmark of multiple sclerosis (MS) is the formation multifocal demyelinating lesions in central nervous system (CNS). Stimulation innate receptors has been shown to suppress experimental autoimmune encephalomyelitis (EAE), an MS-like disease mice. Specifically, targeting Toll-like receptor 9 (TLR9) and NOD-like 2 (NOD2) significantly reduced severity. In present work we have developed a novel focal EAE model further study effect signaling on pathology. Focal were induced by...
Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play role in NMOSD. To elucidate the dysfunction, astrocyte was induced C57BL/6 J female mice by intracerebral injection aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown cause dysfunction. delivered central nervous system resulted decreased The ameliorating effect...