A5011395731- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Peripheral Neuropathies and Disorders
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Inflammation biomarkers and pathways
- Regulation of Appetite and Obesity
- Nerve injury and regeneration
- Respiratory Support and Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Thermal Regulation in Medicine
- Sleep and Wakefulness Research
- Thermoregulation and physiological responses
- Chemokine receptors and signaling
- Axon Guidance and Neuronal Signaling
- Circadian rhythm and melatonin
- Long-Term Effects of COVID-19
- Biochemical Analysis and Sensing Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- S100 Proteins and Annexins
University of Southern Denmark
2013-2024
Owens Community College
2014-2018
Philipps University of Marburg
2004
University of Copenhagen
2001
Hvidovre Hospital
2001
Odense University Hospital
1999
Microglia are resident macrophages of the central nervous system that contribute to homeostasis and neuroinflammation. Although known play an important role in brain development, their exact function has not been fully described. Here, we show contrast healthy adult inflammation-activated cells, neonatal microglia a unique myelinogenic neurogenic phenotype. A CD11c+ microglial subset predominates primary myelinating areas developing expresses genes for neuronal glial survival, migration,...
Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in central nervous system (CNS). Their interaction with microglia astrocytes CNS is crucial for regulation neuroinflammation. Previously, we have shown that only but not effectors activate microglia. However, it clear which targets CNS.To understand effects driven by CNS, induced experimental autoimmune encephalomyelitis wild-type mice CD4+ T cell-specific integrin α4-deficient where trafficking into...
The Type I interferons (IFN), beta (IFN-β) and the alpha family (IFN-α), act through a common receptor have anti-inflammatory effects. IFN-β is used to treat multiple sclerosis (MS) effective against experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Mice with EAE show elevated levels of IFNs in central nervous system (CNS), suggesting role endogenous IFN during inflammation. However, therapeutic benefit produced CNS remains be established. aim this study was examine...
Inflammation is a series of processes designed for eventual clearance pathogens and repair damaged tissue. In the context autoimmune recognition inflammatory are usually considered to be pathological. This also true responses in central nervous system (CNS). However, as other tissues, neuroinflammation can have beneficial well pathological outcomes. The complex role encephalitogenic T cells multiple sclerosis its animal model experimental encephalomyelitis (EAE) may derive from heterogeneity...
Innate glial response is critical for the induction of inflammatory mediators and recruitment leukocytes to sites injury in CNS. We have examined involvement type I IFN signaling mouse hippocampus following sterile (transection entorhinal afferents). Type IFNs signal through a receptor (IFNAR), which involves activation regulatory factor (IRF)9, leading IFN-stimulated genes including IRF7, that turn enhances IFN. Axonal transection induced upregulation IRF7 IRF9 hippocampus. Induction mRNAs...
Abstract Tissue response to injury includes expression of genes encoding cytokines and chemokines. These regulate entry immune cells the injured tissue. The synthesis many chemokines involves NF-κB signal transducers activators transcription (STAT). Injury CNS induces glial response. Astrocytes are major population in CNS. We examined STATs chemokine CCL2 their relationship astroglial signaling following axonal transection. Double labeling with Mac-1/CD11b fibrillary acidic protein revealed...
PEGylated liposomes play a critical role in drug delivery systems because they can evade immune recognition. However, conventional methods for synthesizing often involve the direct incorporation of PEG-functionalized lipids, resulting insufficient and inconsistent PEG distribution on liposome surface, which compromises their stability performance. In this study, we present proof-of-concept synthesis approach that utilizes lipid-based initiators to form liposomes, followed by controllable...
Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, core actions endogenous IFN-β signaling stroke are unclear. To address this question, we used two clinically relevant models focal cerebral ischemia,...
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with unknown etiology. Interferon-β (IFN-β), a member type I IFN family, used as therapeutic for MS and signaling pathway implicated in susceptibility. Interferon regulatory factor 7 (IRF7) critical induction positive feedback regulation IFN. To establish whether how endogenous contributes to modulation better understand underlying mechanism, we examined role IRF7 development MS-like mice.The EAE was...
To clarify the significance of immunoglobulin G autoantibody specific for astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin from a neuromyelitis optica patient was administered intrathecally to naïve mice, and distribution pathogenic impact evaluated. A distinct pattern deposition observed subarachnoid subpial spaces where vessels penetrate brain parenchyma, via paravascular route with intraparenchymal perivascular deposition. Perivascular...
Chemokines direct cellular infiltration to tissues, and their receptors signaling pathways represent targets for therapy in diseases such as multiple sclerosis (MS). The chemokine CCL20 is expressed choroid plexus, a site of entry T cells the central nervous system (CNS). receptor CCR6 has been reported be selectively by CD4(+) that produce cytokine IL-17 (Th17 cells). Th17 interferon-gamma (IFNγ)-producing Th1 are implicated induction MS its animal model experimental autoimmune...
The chemokine CCL2 has an important role in the recruitment of inflammatory cells into central nervous system (CNS). A transgenic mouse model that overexpresses CNS shows accumulation leukocytes within perivascular space surrounding vessels, and which infiltrate brain parenchyma following administration pertussis toxin (PTx). This study used contrast-enhanced magnetic resonance imaging (MRI) to quantify extent blood–brain barrier (BBB) disruption this pre- post-PTx compared wild-type mice....
Abstract Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor (GHSR). However, functional interaction of and not very well understood. We demonstrate that GHSR mRNA up‐regulated after food deprivation (48 h) in hypothalamic arcuate nucleus ventromedial seasonal Siberian hamster, Phodopus sungorus . This increase accompanied by a two‐fold elevation circulating ghrelin concentration. Chronic changes feeding state imposed restriction over period 12 weeks during long...
Abstract A remarkable feature of the seasonal adaptation displayed by Siberian hamster ( Phodopus sungorus ) is ability to decrease food intake and body weight (by up 40%) in response shortening photoperiod. The regulating neuroendocrine systems involved this their neuroanatomical molecular bases are poorly understood. We investigated effect photoperiod on expression prohormone convertases 1 (PC1/3) 2 (PC2) endoproteolytic processing neuropeptide precursor pro‐opiomelanocortin (POMC) within...
Innate receptors, including Toll like receptors (TLRs), are implicated in pathogenesis of CNS inflammatory diseases such as multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). TLR response to pathogens or endogenous signals includes production immunoregulatory mediators. One these, interferon (IFN)β, a Type I IFN, plays protective role MS EAE. We have previously shown that intrathecal administration selected ligands induced IFNβ infiltration...
Abstract Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system (CNS) most frequently mediated by serum autoantibodies against water channel aquaporin 4, expressed on CNS astrocytes, resulting in primary astrocytopathy. There no cure for NMO, and treatment with Type I interferon (IFNI)‐IFNβ ineffective or even detrimental. We have previously shown that both NMO lesions associated microglial activation were reduced mice lacking receptor IFNβ. However, role...
Antibodies with specificity for myelin oligodendrocyte glycoprotein (MOG) are implicated in multiple sclerosis and related diseases. The pathogenic importance of anti-MOG antibody primary demyelinating pathology remains poorly characterized. objective this study is to investigate whether administration would be sufficient demyelination determine if type I interferon (IFN) signaling plays a similar role antibody-mediated pathology, as has been shown neuromyelitis optica-like pathology....