A5030741318- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Ion Transport and Channel Regulation
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Multiple Sclerosis Research Studies
- Receptor Mechanisms and Signaling
- interferon and immune responses
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Antimicrobial Peptides and Activities
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Spectroscopy and Quantum Chemical Studies
- Neuroendocrine regulation and behavior
- Glaucoma and retinal disorders
- Pain Mechanisms and Treatments
- Hereditary Neurological Disorders
- MRI in cancer diagnosis
- Cytokine Signaling Pathways and Interactions
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Herpesvirus Infections and Treatments
Aarhus University
2013-2019
Danish Diabetes Academy
2019
Danish National Research Foundation
2015-2017
University of Southern Denmark
2006-2015
Aarhus University Hospital
2014
Lund University
1956
Abstract Background Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are expressed by microglia infiltrating macrophages following ischemic stroke. Whereas IL-1β is primarily neurotoxic in stroke, TNF-α may have and/or neuroprotective effects. We investigated whether synthesized overlapping or segregated populations of cells after stroke mice. Methods used flow cytometry immunohistochemistry to examine cellular co-expression at 6, 12 24 hours permanent middle cerebral artery...
Reactive gliosis is a prominent feature of neurodegenerative and neuroinflammatory disease in the CNS, yet stimuli that drive this response are not known. There growing appreciation signaling through Toll-like receptors (TLRs), which key to generating innate responses infection, may have pathogen-independent roles. We show TLR2 was selectively upregulated by microglia denervated zones hippocampus stereotactic transection axons entorhinal cortex. In mice lacking TLR2, there were transient,...
Herpes simplex viruses (HSVs) are highly prevalent neurotropic viruses. While they can replicate lytically in cells of the epithelial lineage, causing lesions on mucocutaneous surfaces, HSVs also establish latent infections neurons, which act as reservoirs virus for subsequent reactivation events. Immunological control HSV involves activation innate immune pattern-recognition receptors such TLR3, detects double-stranded RNA and induces type I IFN expression. Humans with defects TLR3/IFN...
Abstract Within the central nervous system, astrocytes and microglia are primary responders to endogenous ligands released upon injury stress, as well infectious pathogens. Toll‐like receptors (TLRs) implicated in recognition of both types stimulus. Whether respond strongly TLR agonists remains contentious. In this study, we have rigorously purified determine their capacity for autonomous response, absence microglia. We used flow cytometry differential adhesion a myeloid lineage‐specific...
The Type I interferons (IFN), beta (IFN-β) and the alpha family (IFN-α), act through a common receptor have anti-inflammatory effects. IFN-β is used to treat multiple sclerosis (MS) effective against experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Mice with EAE show elevated levels of IFNs in central nervous system (CNS), suggesting role endogenous IFN during inflammation. However, therapeutic benefit produced CNS remains be established. aim this study was examine...
Blocking of sortilin ligand binding prevents neuropathic pain by inhibiting BDNF-induced spinal KCC2 down-regulation.
Mutations in the neuron-specific α3 isoform of Na+/K+-ATPase are found patients suffering from Rapid onset Dystonia Parkinsonism and Alternating Hemiplegia Childhood, two closely related movement disorders. We show that mice harboring a heterozygous hot spot disease mutation, D801Y (α3+/D801Y), suffer abrupt hypothermia-induced dystonia identified by electromyographic recordings. Single-neuron vivo recordings awake α3+/D801Y revealed irregular firing Purkinje cells their synaptic targets,...
Abstract The vital gradients of Na + and K across the plasma membrane animal cells are maintained by Na,K-ATPase, an αβ enzyme complex, whose α subunit carries out ion transport ATP hydrolysis. specific roles β isoforms less clear, though β2 is essential for motor physiology in mammals. Here, we show that compared to β1 β3, stabilizes -occluded E1P state relative outward-open E2P effect mediated its transmembrane domain. Molecular dynamics simulations further demonstrate tilt angle helix...
The Na(+)/K(+)-ATPases maintain Na(+) and K(+) electrochemical gradients across the plasma membrane, a prerequisite for electrical excitability secondary transport in neurons. Autosomal dominant mutations human ATP1A3 gene encoding neuron-specific Na(+)/K(+)-ATPase α3 isoform cause different neurological diseases, including rapid-onset dystonia-parkinsonism (RDP) alternating hemiplegia of childhood (AHC) with overlapping symptoms, hemiplegia, dystonia, ataxia, hyperactivity, epileptic...
Toll-like receptors (TLRs) are best known as initiators of the innate immune response to pathogens. Recent reports now reveal intriguing roles for TLRs in central nervous system (CNS). These include regulation neuroinflammation and neurite outgrowth. The archetypal Toll protein Drosophila melanogaster was implicated development system. Now similar functions have been uncovered mammalian orthologs, TLRs. expressed on CNS glia neurons may recognize endogenous ligands participate both responses...
Background. Currently, radiation treatments are being optimised based on in vivo imaging of radioresistant, hypoxic tumour areas. This study aimed at detecting nicotinamide's reduction acute hypoxia a mouse model by two clinically relevant magnetic resonance (MRI) methods ultra-high field strength. Material and methods. The C3H mammary carcinoma was grown to 200 mm3 the right rear foot CDF1 mice. mice were anaesthetised with ketamine xylazine prior imaging. A treatment group received...