A5052368788- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Neurological diseases and metabolism
- CRISPR and Genetic Engineering
- Nerve injury and regeneration
- RNA regulation and disease
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Speech and Audio Processing
- Music and Audio Processing
- Visual perception and processing mechanisms
- Aesthetic Perception and Analysis
- Neural and Behavioral Psychology Studies
- Cellular transport and secretion
- Flood Risk Assessment and Management
- Porphyrin Metabolism and Disorders
- Vitamin K Research Studies
- Transcranial Magnetic Stimulation Studies
- Glycosylation and Glycoproteins Research
- Cancer-related cognitive impairment studies
- Emotion and Mood Recognition
- Nuclear Receptors and Signaling
- Gait Recognition and Analysis
- Cerebrovascular and genetic disorders
Novo Nordisk (Denmark)
2024
University of Delaware
2021-2023
Curtin University Sarawak
2023
Al-Neelain University
2022
York University
2021
Lundbeck (Denmark)
2013-2019
Washington University in St. Louis
2006-2010
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103
2006
University of Göttingen
2004-2006
Mutations in the gene encoding phospholipase A(2) group VI (PLA2G6) are associated with two childhood neurologic disorders: infantile neuroaxonal dystrophy (INAD) and idiopathic neurodegeneration brain iron accumulation (NBIA). INAD is a severe progressive psychomotor disorder which axonal spheroids found brain, spinal cord, peripheral nerves. High globus pallidus an inconsistent feature of INAD; however, it diagnostic criterion NBIA, describes clinically genetically heterogeneous disorders...
The inherently low regenerative capacity of the CNS demands effective strategies to inhibit neurodegeneration in acute lesions but also slowly progressive neurological disorders. Therefore, therapeutic targets that can interact with degeneration cascade block, not just postpone, neuronal need be defined. Bcl-X(L), a protein protecting integrity mitochondrial membrane potential, was investigated for its neuroprotective properties long-term vivo model cell death. An AAV-2-based vector used...
Blocking of sortilin ligand binding prevents neuropathic pain by inhibiting BDNF-induced spinal KCC2 down-regulation.
Sortilin is a type I membrane glycoprotein belonging to the vacuolar protein sorting 10 (Vps10p) family of receptors and most abundantly expressed in central nervous system. has emerged as key player regulation neuronal viability been implicated possible therapeutic target range disorders. Here, identification AF40431, first reported small-molecule ligand sortilin, reported. Crystals sortilin-AF40431 complex were obtained by co-crystallization structure was solved 2.7 Å resolution. AF40431...
Despite the significant impact of lower limb symptoms on everyday life activities in Parkinson's disease (PD), knowledge neural correlates deficits is limited.We ran an fMRI study to investigate movements individuals with and without PD.Participants included 24 PD 21 older adults who were scanned while performing a precisely controlled isometric force generation task by dorsiflexing their ankle. A novel MRI-compatible ankle dorsiflexion device that limits head motion during motor tasks was...
Non-speech emotion recognition has a wide range of applications including healthcare, crime control and rescue, entertainment, to name few. Providing these using edge computing great potential, however, recent studies are focused on speech-emotion complex architectures. In this paper, non-speech-based system is proposed, which can rely analyse emotions conveyed through non-speech expressions like screaming crying. particular, we explore knowledge distillation design computationally efficient...
Abstract Functional characterization of disease‐related proteins, their splice variants and dominant negative mutants in the context complex CNS tissues such as brain retina is frequently assessed by vivo gene transfer. For correct interpretation results it imperative that protein under investigation unambiguously detected transduced cell types can be distinguished from any endogenously expressed physiological variants. Therefore first systematic evaluation epitope tags used to trace...
Background While motor coordination problems are frequently reported among individuals with Parkinson’s disease (PD), the effects of on performance multi-limb movements and brain changes underlying impaired not well-documented. Objective Functional magnetic resonance imaging (fMRI) was used to examine differences in activity during a task that involved non-homologous limbs (i.e., ipsilateral hand foot) without PD. Methods Participants included 20 PD healthy control participants (HC). They...
In Sudan, up to date, artificial recharge with surface water has been rarely investigated in papers. This paper proposed a method identify and evaluate potential site for of groundwater the Biteira district. The targeted area lies southern part Sudan is underlain by basement rocks. population's growth, alongside climate change which caused desertification, augmented resources' stress over recent years. Moreover, an alternative resource essential due limited aquifers. research integrates...
Whether attention alters appearance or just changes decision criteria continues to be controversial. When subjects are forced choose which of two equal targets, one has been pre-cued, a higher contrast, they tend the cued target. This interpreted as increasing apparent contrast However, when must decide whether targets have unequal respond veridically with no effect attention. The discrepancy between these comparative and equality judgments is explained by altering but not appearance. We...
Abstract Background Evidence suggests glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) may have therapeutic potential in Alzheimer’s disease (AD). Cumulative evidence has indicated a reduction cognitive decline people with AD, while real‐world shown decreased dementia risk patients type 2 diabetes. Non‐clinical data reveal that GLP‐1RAs impact neuroinflammation and other biological processes believed to be involved AD pathophysiology, including effects on central peripheral immune cells....
Since Zika virus (ZIKV) first emerged as a public health concern in 2015, our ability to identify and track the long-term neurological sequelae of prenatal infection humans has been limited. Our lab developed rat model maternal ZIKV with associated vertical transmission fetus that results significant brain malformations neonatal offspring. Here, we use this conjunction longitudinal magnetic resonance imaging (MRI) expand understanding consequences order characteristic neurodevelopmental...
Gait analysis plays a crucial role in detecting gait abnormalities and providing technical assistance clinical rehabilitation. However, traditional methods, which rely on gold standard acquisition systems, are limited to indoor activities. On the other hand, wearable sensors like Inertia Measurement Units (IMUs) offer convenience but prone noise disturbance. To enable long-term analysis, recent trends have shifted towards developing Machine Learning (ML)-based approaches. A significant...
Whether attention alters appearance or just changes decision criteria continues to be controversial. When subjects are forced choose which of two equal targets, one has been pre-cued, a higher contrast, they tend the cued target. This interpreted as increasing apparent contrast However, when must decide whether targets have unequal respond veridically with no effect attention. The discrepancy between these comparative and equality judgments is explained by altering but not appearance. We...
Sortilin was first identified based on its activity as part of intracellular protein sorting machinery. Recently, it discovered that sortilin also acts a cell surface receptor for the propeptide form nerve growth factor (proNGF), progranulin, and neurotensin. The interaction to these neurotrophic ligands is linked diseases nervous system lead neurodegeneration neuropathic pain. Blocking may prevent or slow progress disorders. In vitro screening assays blocking compounds peptides are standard...
In this paper, we propose to utilise diffusion models for data augmentation in speech emotion recognition (SER). particular, present an effective approach improved denoising probabilistic (IDDPM) generate synthetic emotional data. We condition the IDDPM with textual embedding from bidirectional encoder representations transformers (BERT) high-quality samples different speakers' voices\footnote{synthetic URL: \url{https://emulationai.com/research/diffusion-ser.}}. implement a series of...