A5016683415- Neonatal Health and Biochemistry
- Neuroscience and Neuropharmacology Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Heme Oxygenase-1 and Carbon Monoxide
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Hemoglobin structure and function
- Ion channel regulation and function
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Drug Transport and Resistance Mechanisms
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Protein Interaction Studies and Fluorescence Analysis
- Erythrocyte Function and Pathophysiology
- Renin-Angiotensin System Studies
- Growth Hormone and Insulin-like Growth Factors
- Cellular transport and secretion
- Neurogenesis and neuroplasticity mechanisms
- Cholinesterase and Neurodegenerative Diseases
- HIV Research and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Microbial Fuel Cells and Bioremediation
Aarhus University Hospital
1972-2023
Aarhus University
1970-2020
Lundbeck (Denmark)
2013
Pfizer (United States)
2010
University of Copenhagen
1967-2010
Proteostasis Therapeutics (United States)
2010
Princeton University
2007-2008
Collaborative Group (United States)
1991
Royal Danish Defence College
1988
Glostrup Hospital
1972
Inheritance of the apoE4 allele (ε4) increases risk developing Alzheimer's disease; however, mechanisms underlying this association remain elusive. Recent data suggest that inheritance ε4 may lead to reduced apoE protein levels in CNS. We therefore examined brains, CSF and plasma ε2/2, ε3/3, ε4/4 targeted replacement mice. These mice showed a genotype-dependent decrease levels; ε2/2 >ε3/3 >ε4/4. Next, we sought examine relative contributions apoE3 ε3/4 mouse brains. ApoE4 represented...
In patients with the acquired immunodeficiency syndrome (AIDS), rate of relapse after primary treatment for cryptococcal meningitis remains high. We conducted a controlled, doubleblind trial to evaluate efficacy maintenance therapy fluconazole. At entry into study, all participants had sterile cultures cerebrospinal fluid, blood, and urine following standardized course culture-proved meningitis. The were randomly assigned take either fluconazole or placebo as therapy. dose was 100 mg daily...
Increasing evidence supports a decisive role for inflammation in the neurodegenerative process of Parkinson's disease (PD). The immune response PD seems to involve, not only microglia, but also other cells infiltrated into brain. Indeed, we observed here infiltration macrophages, specifically CD163+ area neurodegeneration 6-hydroxydopamine (6-OHDA) model. Therefore, investigated therapeutic potential macrophages modulate local microglia brain achieve neuroprotection. To do so, designed...
After binding of bilirubin to human serum albumin (1:1), a train relaxational changes conformation takes place. The late part these processes, occurring in the time interval 1-500 s, has been studied by recording light absorption. Similar processes have demonstrated after fatty acid anion bilirubin-albumin complex as well pH-jump from 6 9. Solvent perturbation spectra obtained on addition 20% sucrose failed demonstrate exposure chromophores surrounding medium. Xanthobilirubinate which single...
AbstractDeterminations of the low equilibrium concentrations non-albumin-bound unconjugated bilirubin in serum by a kinetic method have been done on normal umbilical cord blood serum, from exchange transfusions icteric newborns, and adult serum. The are about 10−9 M 10−5 infant sera. latter shows little correlation between total non-bound bilirubin, indicating that there is considerable variation binding to albumin.Key Words: Albuminbilirubinexchange transfusionsicterus neonatorumperoxidase
Alpha-synuclein (a-syn) can aggregate and form toxic oligomers insoluble fibrils which are the main component of Lewy bodies. Intra-neuronal bodies a major pathological characteristic Parkinson's disease (PD). These fibrillar structures act as seeds accelerate aggregation monomeric a-syn. Indeed, recent studies show that injection preformed a-syn (PFF) into rodent brain induce endogenous resulting in neuronal dysfunction eventual cell death. We injected 8 μg murine PFF, or soluble right...
Degeneration of noradrenergic neurons may underlie the disabling nonmotor symptoms in patients with Parkinson disease (PD). Quantification loss by means neuroimaging has been limited lack radioligands that are selective for neurotransmission. The radioligand (<i>S,S</i>)-<sup>11</sup>C-2-(α-(2-methoxyphenoxy)benzyl)morpholine (<sup>11</sup>C-MeNER) is a highly inhibitor noradrenaline transporters, and PET studies suggest this suitable quantitative deficits human brain vivo. In present...
The number of functionally active synapses provides a measure neural integrity, with reductions observed in neurodegenerative disorders. [11C]UCB-J binds to synaptic vesicle 2A (SV2A) transmembrane protein located secretory vesicles. We aimed assess PET as an vivo biomarker regional cerebral SV2A density rat lesion models neurodegeneration. Healthy anesthetized rats had and arterial blood sampling. compared different describing brain uptake kinetics determine its distribution. Blocking...
The positron emission tomography (PET) tracer [18F]GE-179 binds to the phencyclidine (PCP) site in open N-methyl-D-aspartate receptor ion channel (NMDAR-IC). To demonstrate that PET can visualise increased uptake by active NMDAR-ICs and this be blocked PCP antagonist S-ketamine, 15 rats had an electrode unilaterally implanted their ventral hippocampus. Seven no stimulation, five received pulsed 400 µA supra-threshold 60 Hz stimulation alone, three intravenous S-ketamine injection prior...
ABSTRACT The mode of action a recently isolated gonadal protein, termed FSH-suppressing protein (FSP) or follistatin, on basal and gonadotrophin-releasing hormone (GnRH)-stimulated release FSH LH pituitary cell content was examined in rat cultures compared with the previously reported effects inhibin. Pituitary cells were cultured for 3–9 days presence graded doses FSP rates changes contents determined during this period. suppressed both rate median inhibitory concentrations (IC 50 ) 135 161...
Binding of bilirubin and L-tryptophan to dansylated albumins was investigated. Dansylation less than one lysine residue per molecule albumin did not affect the binding, but decreased indicating that dansylation had taken place in or near l-tryptophan-binding site. Native albumin-bilirubin 1:1 complex showed same affinity for L-tryptophan. The results indicate that, although are bound region, perhaps a common cavity molecule, such is sufficiently large contain both ligands.
Quantitative determination of bilirubin (unconjugated, by chloroform extraction), diglucuronide (by the isotope derivative method) and albumin was done in 26 specimens amniotic fluid from cases suspected hemolytic disease utero.A hypothetical scheme fetal metabolism is proposed, presuming unidirectional transplacental elimination unconjugated bilirubin. On basis theoretical considerations mechanism conjugation it thought possible that liver chemical equilibrium with its diglucuronide. Both...
The single bile duct cannulated rat model was used for short-term intestinal absorption studies. Rats were randomly assigned to three groups: (A) cannulated, (B) control laparotomy and (C) no treatment. body weight health of the rats monitored before until day 5 after surgery, while flow measured in group A on 2. On fifth day, tail vein blood harvested, alanine aminotransferase, aspartate alkaline phosphatase total bilirubin quantified. Analysis variance showed significant difference between...