A5065296497- Parkinson's Disease Mechanisms and Treatments
- Food Allergy and Anaphylaxis Research
- RNA Interference and Gene Delivery
- Nuclear Receptors and Signaling
- Renal Transplantation Outcomes and Treatments
- Nerve injury and regeneration
- Virus-based gene therapy research
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Hepatitis C virus research
- Contact Dermatitis and Allergies
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Pulmonary Hypertension Research and Treatments
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Allergic Rhinitis and Sensitization
- Reproductive Physiology in Livestock
- Signaling Pathways in Disease
- Retinal Diseases and Treatments
- Social Sciences and Policies
- Sports and Physical Education Studies
Instituto de Biologia Experimental e Tecnológica
2019
Centro Científico Tecnológico - San Juan
2016
Complejo Hospitalario Universitario de Santiago
2002-2014
University of Coimbra
2004-2011
University of Göttingen
2006-2011
Centro de Neurociências e Biologia Celular
2011
Center for Neurosciences
2011
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103
2006-2010
Hertie Foundation
2010
Vall d'Hebron Hospital Universitari
2007
Posttranslational modification of proteins by attachment small ubiquitin-related modifier (SUMO) contributes to numerous cellular phenomena. Sumoylation sometimes creates and abolishes binding interfaces, but increasing evidence points another role for sumoylation in promoting the solubility aggregation-prone proteins. Using purified α-synuclein, an protein implicated Parkinson’s disease that was previously reported be sumoylated upon overexpression, we compared aggregation kinetics...
Fibrillar αSynuclein is the major constituent of Lewy bodies and neurites, protein deposits characteristic for Parkinson's disease (PD). Multiplications gene, as well point mutations cause familial PD. However, exact role in neurodegeneration remains uncertain. Recent research invertebrates has suggested that oligomeric rather than fibrillizing mediates neurotoxicity. To investigate impact aggregation on progression neurodegeneration, we expressed variants with different fibrillation...
Parkinson's disease is a neurodegenerative disorder characterized by severe motor deficits mainly due to degeneration of dopaminergic neurons in the substantia nigra. Decreased levels cell's most important anti-oxidant, glutathione, have been detected nigral Parkinson patients, but it unknown if they are cause or merely consequence disease. To elucidate glutathione depletion causes selective neurons, we down-regulated synthesis different brain areas adult rats viral vector-based RNAi...
Neuropeptide Y (NPY) produced by arcuate nucleus (ARC) neurons has a strong orexigenic effect on target neurons. Hypothalamic NPY levels undergo wide-ranging oscillations during the circadian cycle and in response to fasting peripheral hormones (from 0.25 10-fold change). The aim of present study was evaluate impact moderate long-term modulation within ARC food consumption, body weight gain hypothalamic neuropeptides. We achieved physiological overexpression (3.6-fold increase)...
Summary Background Alcohol consumption is associated with increased serum IgE of unknown specificity. Objective To investigate the prevalence specific to cross‐reactive carbohydrate determinants (CCDs) in adults, and its relation alcohol consumption. Methods Population‐based survey 457 adults (218 abstainers, 195 light‐to‐moderate drinkers, 44 heavy drinkers). Specific determinations included a CCD (MUXF 3 , N ‐glycan bromelain), pollens ( Lolium perenne Olea europaea ), Hymenoptera venoms...
Pleural effusion appears in approximately 40% of patients with pneumonia. Given that microbiology results are often negative, its diagnosis is frequently based on clinical criteria. Our study consisted 266 patients, divided into infectious (n = 34), tuberculous 54), paraneoplastic 63), miscellaneous exudates 53), and transudates 62). Interleukin (IL)-6, IL-8, IL-1beta were measured the pleural fluid serum all as well different cell populations fluid. Analysis receiver operating...
Background: N‐glycans in plant and invertebrate glycoproteins can induce extensive IgE cross‐reactivity therefore limiting the specificity of vitro allergy tests. sensitization to (cross‐reactive carbohydrate determinants, CCDs) may be increased heavy drinkers, who show reactivity aeroallergens, latex, Hymenoptera venoms. The peanut, a CCD‐bearing allergen, is leading cause severe food allergic reactions many populations. Aim study: To investigate potential interference CCDs with...
Purpose/Aim of the study: Diabetic retinopathy (DR) is a leading cause blindness in working age adults developed countries. Changes metabolites and metabolic pathways retina caused by hyperglycemia may compromise physiology retina. Using nuclear magnetic resonance (NMR) spectroscopy, we aimed to investigate effect diabetes on levels intermediate rat retinas that could be affected.Materials Methods: Diabetes was induced male Wistar rats with single injection streptozotocin (65 mg/Kg, i.p.)....
Current evidence suggests that cyclosporine (CsA) concentration in blood samples taken 2 hours after Neoral microemulsion (Novartis Pharmaceuticals; East Hanover, NJ) administration (C2) predicts clinical events transplant patients better than the pre-dose (trough) (C0). Similarly, previous findings have shown metabolites/CsA ratio is substantially lower C2 C0 samples; however between-monoclonal immunoassay differences for received little attention literature. In 56 and 60 from renal...
Kizur, A.; Garrido, M.J.; Konrad, J.L.; Crudeli, G.A.; Gatica-García, R.: Inducción de ciclos estrales en vacas lecheras con anestro posparto utilizando progesterona y hormonas gonadotróficas. Rev. vet. 26: 1, 13-16, 2015