A5064861384- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Immune cells in cancer
- Multiple Sclerosis Research Studies
- Chemokine receptors and signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammation biomarkers and pathways
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- MRI in cancer diagnosis
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Advanced Neuroimaging Techniques and Applications
- Bone and Joint Diseases
- Neurological Disease Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Metal Extraction and Bioleaching
- Nuclear Receptors and Signaling
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Chromium effects and bioremediation
- Systemic Lupus Erythematosus Research
- Advancements in Materials Engineering
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
University of Southern Denmark
2013-2024
Gdańsk Medical University
2023
Owens Community College
2013-2019
Jagiellonian University
2012-2017
University of Warsaw
2014-2016
National Institutes of Health
2015
University College London
2006-2010
National Hospital for Neurology and Neurosurgery
2010
Royal Institution of Great Britain
2006
Science Oxford
2006
Microglia are resident macrophages of the central nervous system that contribute to homeostasis and neuroinflammation. Although known play an important role in brain development, their exact function has not been fully described. Here, we show contrast healthy adult inflammation-activated cells, neonatal microglia a unique myelinogenic neurogenic phenotype. A CD11c+ microglial subset predominates primary myelinating areas developing expresses genes for neuronal glial survival, migration,...
Tissue-resident antigen-presenting cells (APC) exert a major influence on the local immune environment. Microglia are resident myeloid in central nervous system (CNS), deriving from early post-embryonic precursors, distinct adult hematopoietic lineages. Dendritic (DC) and macrophages infiltrate CNS during experimental autoimmune encephalomyelitis (EAE). not considered to be as effective APC DC or macrophages. In this work we compared antigen presenting capacity of CD11c+ CD11c− microglia...
Insulin-like growth factor 1 (IGF-1) is a peptide hormone essential for the proper development and of organism, as complete knockout
Abstract Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is likely source autoantigens or by promoting bystander tissue damage. Therefore, important identify mechanisms that inhibit NET formation. elastase (NE)-dependent chromatin decondensation key event in the release NETs release. We hypothesized inhibitors NE, secretory leukocyte protease inhibitor...
Inflammation is a series of processes designed for eventual clearance pathogens and repair damaged tissue. In the context autoimmune recognition inflammatory are usually considered to be pathological. This also true responses in central nervous system (CNS). However, as other tissues, neuroinflammation can have beneficial well pathological outcomes. The complex role encephalitogenic T cells multiple sclerosis its animal model experimental encephalomyelitis (EAE) may derive from heterogeneity...
Microglia are resident immune cells of the central nervous system. Their development and maintenance depend on stimulation Colony Stimulating Factor-1 receptor (CSF1R). play an important role in neurodevelopment a population microglia that expresses complement CD11c is critical for primary myelination. This virtually absent healthy adult brain but increases dramatically upon neuroinflammatory conditions, these suggested to protective system (CNS) diseases. To date, molecular trigger their...
Abstract Secretory leukocyte proteinase inhibitor (SLPI) is a well-established of serine proteases such as human neutrophil elastase (HNE) and NF-κB regulatory agent in immune cells. In this paper, we report that SLPI plays previously uncharacterized role regulating activation plasmacytoid dendritic cells (pDCs). As the main source IFN type I (IFNI), pDCs are crucial contributors to inflammatory likely wound-healing responses associated with psoriasis. The mechanisms responsible for...
Microglia have recently been established as key regulators of brain development. However, their role in neuronal subtype specification remains largely unknown. Using three different co-culture setups, we show that microglia-secreted factors enhance dopaminergic differentiation somatic and induced pluripotent stem cell-derived human neural cells (NSCs). The effect was consistent across NSC microglial cell lines independent prior activation, although restricted to microglia embryonic origin....
Background: The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify miRNAs related in vivo de- and remyelination. We further investigated the role miR-146a miR-146a-deficient (KO) mice: this miRNA is differentially expressed MS lesions promotes differentiation oligodendrocyte precursor cells (OPCs) during remyelination, but its has not been examined demyelination. Methods: MicroRNAs were by Agilent Mouse Microarray corpus callosum CPZ-induced demyelination Demyelination,...
Background: MiR-146a is an important regulator of innate inflammatory responses and also implicated in cell death survival. Methods: By sorting CNS resident cells, microglia were the main cellular source miR-146a. Therefore, we investigated function phenotype miR-146a knock-out (KO) mice, analyzed proteome KO wild-type (WT) by LC-MS/MS, examined expression different brain lesions patients with multiple sclerosis (MS). Results: When stimulated LPS or myelin vitro, from mice expressed higher...
CCL2 is a chemokine that can be induced during neuroinflammation to recruit immune cells, but its role in the central nervous system (CNS) unclear. Our aim was better understand role. We CNS of naive CCL2-deficient mice using intrathecally administered replication-defective adenovirus and examined cell infiltration by flow cytometry. expression pronounced unexpected recruitment regulatory IFNγ-producing T cells from blood, possibly related defective egress monocytes bone marrow. Infiltration...
Microglia, the resident immune cells of central nervous system (CNS), play a major role in damage progression and tissue remodeling after acute CNS injury, including ischemic stroke (IS) spinal cord injury (SCI). Understanding molecular mechanisms regulating microglial responses to may thus reveal novel therapeutic targets promote repair. Here, we investigated tumor necrosis factor receptor 2 (TNFR2), transmembrane previously associated with pro-survival neuroprotective responses, shaping...
Immune cells regulate cell surface receptor expression during their maturation, activation, and motility. Although many of these receptors are regulated largely at the level expression, protease-mediated ectodomain shedding represents an alternative means refashioning immune cells. Shedding is attributed to a family disintegrin metalloprotease domain (ADAM) metalloproteases, including ADAM17. ADAM17 well known contribute innate response, mainly by releasing TNF-α, much less about whether/how...
Diffusion kurtosis imaging (DKI) is an modality that yields novel disease biomarkers and in combination with nervous tissue modeling, provides access to microstructural parameters. Recently, DKI subsequent estimation of model parameters has been used for assessment changes neurodegenerative diseases associated animal models. In this study, mouse spinal cords from the experimental autoimmune encephalomyelitis (EAE) multiple sclerosis (MS) were investigated first time using biophysical...
Abstract Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system (CNS) most frequently mediated by serum autoantibodies against water channel aquaporin 4, expressed on CNS astrocytes, resulting in primary astrocytopathy. There no cure for NMO, and treatment with Type I interferon (IFNI)‐IFNβ ineffective or even detrimental. We have previously shown that both NMO lesions associated microglial activation were reduced mice lacking receptor IFNβ. However, role...
Eosinophils constitute an important component of helminth immunity and are not only associated with various allergies but also linked to autoinflammatory disorders, including the skin disease psoriasis. Here we demonstrate functional relationship between eosinophils plasmacytoid dendritic cells (pDCs) as related diseases. We previously showed that pDCs colocalize neutrophil extracellular traps (NETs) in psoriatic skin. found near neutrophils NETs, suggesting pDC responses can be regulated by...