A5086631744- Glioma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- DNA Repair Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Microtubule and mitosis dynamics
- Immune Response and Inflammation
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Tissue Engineering and Regenerative Medicine
- Advanced Proteomics Techniques and Applications
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
Aarhus University Hospital
2024-2025
Aarhus University
2024
Danish Cancer Society
2018-2023
Aalborg University
2018-2020
University of Gothenburg
2017
Faculty (United Kingdom)
2015
Abstract Background: Despite advancements in precision oncology, only a minor subset of patients can be matched with effective targeted therapy, and even fewer experience sustained benefits. This is partly because current approaches, such as genomic profiling alone, do not fully capture the complexity tumor biology. Integrating ex vivo drug sensitivity testing patient-derived cells may offer more comprehensive solution, helping identify treatments for limited standard options or failed...
// Anna Wenger 1 , Susanna Larsson Danielsson 2 Kirstine Juul Elbæk Petronella Kettunen 3,4 Magnus Tisell 5 Sabel 6,7 Birgitta Lannering Claes Nordborg 8 Elizabeth Schepke 1,7 and Helena Carén Department of Pathology, Sahlgrenska Cancer Center, Institute Biomedicine, Academy, University Gothenburg, Sweden Oncology, Clinical Sciences, 3 Psychiatry Neurochemistry, Neuroscience Physiology, 4 Neuropathology, Nuffield Neurosciences, Oxford, John Radcliffe Hospital, United Kingdom Rehabilitation,...
Background: MiR-146a is an important regulator of innate inflammatory responses and also implicated in cell death survival. Methods: By sorting CNS resident cells, microglia were the main cellular source miR-146a. Therefore, we investigated function phenotype miR-146a knock-out (KO) mice, analyzed proteome KO wild-type (WT) by LC-MS/MS, examined expression different brain lesions patients with multiple sclerosis (MS). Results: When stimulated LPS or myelin vitro, from mice expressed higher...
Glioblastoma (GBM) is among the deadliest of solid tumors with median survival rates approximately 12–15 months despite maximal therapeutic intervention. A rare population self-renewing cells referred to as GBM cancer stem-like (GSCs) are believed be source inevitable recurrence in GBM. GSCs exhibit preferential activation DNA damage response pathway (DDR) and evade ionizing radiation (IR) therapy by superior execution repair compared their differentiated counterparts, (DGCs). Replication...
Summary Glioblastomas (GBM) are renowned for their pronounced intratumoral heterogeneity, characterized by a diverse array of plastic cell types, which poses significant challenge to effective targeting and treatment [1]. Recent research has documented the presence neuronal-progenitor-like transcriptomic states GBM [2, 3], notably in leading edge tumor, where synaptic input from adjacent neurons drives disease proliferation [4]. However, conflicting observations regarding excitability,...
Abstract Background Similar to humans, the horse is a long-lived, athletic species. The use of mesenchymal stromal cells (MSCs) relatively new frontier, but has been used with promising results in treating joint diseases, e.g., osteoarthritis. It believed that MSCs exert their main therapeutic effects through secreted trophic biomolecules. Therefore, it increasingly important characterize MSC secretome. shown effect strongly influenced by environment host compartment, and crucial issue when...
Abstract Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance GSCs remain largely unknown. Chromatin state and the accessibility DNA lesions repair machineries are crucial maintenance genomic stability. Understanding functional impact chromatin remodeling on in may lay foundation advancing efficacy radio-sensitizing therapies. Here, we present results...
Abstract Background Glioblastoma (GBM) is a highly lethal malignancy for which neoangiogenesis serves as defining hallmark. The anti-VEGF antibody, bevacizumab, has been approved the treatment of recurrent GBM, but resistance universal. Methods We analyzed expression data GBM patients treated with bevacizumab to discover potential mechanisms. Patient-derived xenografts (PDXs) and cultures were interrogated effects phosphofructokinase-1, muscle isoform (PFKM) loss on tumor cell motility,...
Stem cells have great potential for tissue regeneration, but before stem cell populations can be used in the clinic, it is crucial that been definitely characterized by a set of specific markers. Although there attempts to identify immunophenotypic markers characterize equine mesenchymal stromal (MSCs), immunophenotyping MSCs still challenging due limited availability suitable antibodies high quality and consistent performance across different laboratories. The aim this study was evaluate...
Abstract Glioblastomas (GBM) are known for their significant intratumor heterogeneity, featuring a variety of plastic cell types that make effective treatment challenging. Recent studies have shown neuronal-progenitor-like transcriptomic states at the leading edge tumor receive synaptic input from nearby neurons, which drives disease proliferation. However, excitability GBM cells remains controversial, with observations ranging non-excitable to neuron-like excitability, complicating our...
Abstract AIMS Plasma is a valuable source for identifying non-invasive biomarkers, and when combined with an examination of the highly dynamic proteome, it has potential to lead identification novel biomarkers in glioma. The aim this study was uncover plasma-based protein adult malignant METHOD Mass spectrometry-based proteomics tandem mass tag (TMT) labelling plasma from healthy individuals gliomas performed. A differential abundance analysis carried out identify proteins that were...
Glioblastoma (GBM) is the deadliest and most common primary brain tumor with median survival rates of less than two years. GBM defined by hallmarks such as uncontrolled cellular proliferation, diffuse infiltration, propensity for necrosis, robust angiogenesis, resistance to apoptosis rampant genomic instability. Inter- intra-tumoral heterogeneity, plasticity de-regulated signaling pathways are plausible causes existent therapies in GBM. As current offer only limited benefits, identification...